Acta Scientific Pharmaceutical Sciences,
Год журнала:
2023,
Номер
unknown, С. 26 - 36
Опубликована: Ноя. 1, 2023
The
corona
virus-19
,
which
unexpectedly
heightened
multiple
health
challenges
among
older
adults
beginning
in
December
2019,
continues
to
influence
many
facets
of
elder
including
having
a
possible
role
exacerbating
osteoarthritis
linkages
or
combination
2023
and
possibly
beyond
this
period.At
the
same
time,
recent
2050
prevalence
predictions
that
may
well
be
underestimates
imply
any
effort
minimize
disability
must
highly
warranted
its
own
right,
because
is
major
risk
factor
for
severe
COVID-19
infections.Based
on
key
2022-2023
data
base
posting,
small
body
current
work
strengthens
case
our
view
more
elucidation
interpretation
clinical
significance
presently
alluded
not
overlook
what
has
been
learned
about
population
wellbeing
healthy
aging
from
both
pandemic
as
successes
Blue
Zone
locations.
Frontiers in Systems Biology,
Год журнала:
2024,
Номер
4
Опубликована: Июнь 7, 2024
The
COVID-19
pandemic
generated
large
amounts
of
data
on
the
disease
pathogenesis
leading
to
a
need
for
organizing
vast
knowledge
in
succinct
manner.
Between
April
2020
and
February
2023,
CIAO
consortium
exploited
Adverse
Outcome
Pathway
(AOP)
framework
comprehensively
gather
systematically
organize
published
scientific
literature
pathology.
project
considered
24
pathways
relevant
by
identifying
essential
key
events
(KEs)
19
adverse
outcomes
observed
patients.
While
an
individual
AOP
defines
causally
linked
perturbed
KEs
towards
outcome,
building
network
visually
reflect
interrelatedness
various
outcomes.
In
this
study,
17
those
AOPs
were
selected
based
quality
criteria
computationally
derive
network.
This
primary
highlighted
consider
tissue
specificity
helped
identify
missing
or
redundant
elements
which
then
manually
implemented
final
Such
enabled
visualization
complex
interactions
multifaceted
confirmed
central
role
inflammatory
response
disease.
addition,
study
disclosed
importance
terminology
harmonization
tissue/organ
building.
Furthermore
unequal
completeness
information
contained
tighter
implementation
FAIR
principles
improve
findability,
accessibility,
interoperability
re-usability.
Finally,
underlined
that
describing
specific
SARS-CoV-2
replication
discriminating
physiological
from
pathological
inflammation
is
necessary
but
requires
adaptations
framework.
Hence,
challenges
encountered,
we
proposed
recommendations
ongoing
future
AOP-aligned
consortia
aiming
build
biologically
meaningful
networks
context
of,
not
limited
to,
viral
diseases.
Acta Scientific Pharmaceutical Sciences,
Год журнала:
2023,
Номер
unknown, С. 26 - 36
Опубликована: Ноя. 1, 2023
The
corona
virus-19
,
which
unexpectedly
heightened
multiple
health
challenges
among
older
adults
beginning
in
December
2019,
continues
to
influence
many
facets
of
elder
including
having
a
possible
role
exacerbating
osteoarthritis
linkages
or
combination
2023
and
possibly
beyond
this
period.At
the
same
time,
recent
2050
prevalence
predictions
that
may
well
be
underestimates
imply
any
effort
minimize
disability
must
highly
warranted
its
own
right,
because
is
major
risk
factor
for
severe
COVID-19
infections.Based
on
key
2022-2023
data
base
posting,
small
body
current
work
strengthens
case
our
view
more
elucidation
interpretation
clinical
significance
presently
alluded
not
overlook
what
has
been
learned
about
population
wellbeing
healthy
aging
from
both
pandemic
as
successes
Blue
Zone
locations.
