Clinical Nuclear Medicine,
Год журнала:
2023,
Номер
48(12), С. e572 - e573
Опубликована: Сен. 21, 2023
Recently
developed
radiolabeled
FAPI
(fibroblast-activation
protein
inhibitors)
have
attracted
researcher's
attention
in
diagnosing
various
tumors
because
of
its
high
specificity
and
better
tumor-to-background
ratio.
Increasing
use
68
Ga-FAPI
PET/CT
has
resulted
reporting
incidental
benign
findings
as
well.
We
hereby
present
a
case
suspected
carcinoma
stomach
showing
increased
uptake
primary
tumor
well
subchondral
cysts
bilateral
shoulder
joints
right
hip
joint
on
PET
CT
scan.
Ankylosing
spondylitis
(AS)
is
characterized
by
inflammation
and
osteoblastic
changes
in
the
sacroiliac
joint.
As
a
potential
imaging
method
for
early
assessment
of
AS,
positron
emission
tomography
(PET)
can
quantify
systemic
disease
activity,
which
conducive
to
monitoring
progression
activity
assisting
evaluating
efficacy
treatment.
The
study
was
evaluate
diagnostic
value
aluminium-[18F]fuoride(Al18F)-labelled
fibroblast
activation
protein
inhibitor
(FAPI)
PET/computed
(CT)
AS
investigate
its
ability
assess
during
development
AS.
Twenty
participants
who
met
Assessment
SpondyloArthritis
international
Society
criteria
were
an
active
stage
included
this
from
May
2022
April
2023.
Sixteen
healthy
controls
also
inrolled.
All
underwent
Al18F-NOTA-FAPI-04
PET/CT
after
collecting
clinical
laboratory
results.
correlation
between
positive
joint
count
(PJC)
standard
uptake
ratio
(SUVR,
mean
SUVmax
5
highest
joints/SUVmax
uninvolved
sacrum)
on
PET
various
tests
analyzed.
A
total
2820
joints
observed
20
(median
age
34.5,[21-61]range,
15
men),
with
PJC
1300
(46.7%),
39
uptakes
found
40
(97.5%).
images
revealed
FAPI-04
both
2
without
radiographic
sacroiliitis
stages
varying
degrees
spinal
remaining
participants.
SUVR
positively
correlated
most
assessments
findings
(P
<
.05),
C-reactive
(CRP)
(mg/L;
r
=
0.498,
P
.026).
highly
sensitive
arthritic
tests.
Clinical Nuclear Medicine,
Год журнала:
2023,
Номер
48(7), С. 622 - 624
Опубликована: Апрель 17, 2023
Abstract
A
44-year-old
healthy
volunteer
received
an
18
F-FAPI-04
scan
for
a
normal
biodistribution
and
dosimetry
study.
An
incidental
finding
of
increased
uptake
the
radiotracer
at
L4/5
subarticular
disc
herniation
was
noted,
subsequent
MRI
confirmed
degenerative
nature
lesion.
Clinical Nuclear Medicine,
Год журнала:
2023,
Номер
48(12), С. e588 - e590
Опубликована: Окт. 16, 2023
Abstract
A
54-year-old
man
with
a
history
of
colectomy
for
colorectal
cancer
and
subsequent
liver
metastasectomy
underwent
18
F-FDG
PET/CT
F-FAPI-04
scans
to
evaluate
possible
hepatic
metastasis
revealed
by
contrast-enhanced
MRI.
Both
studies
showed
similarly
increased
uptake
in
metastases,
detected
metastatic
lung
nodule.
Furthermore,
the
images
an
incidental
finding
L3
vertebral,
which
was
not
F-FDG–avid.
review
patient's
previous
CT
MRI
suggests
vertebral
hemangioma.
Research Square (Research Square),
Год журнала:
2022,
Номер
unknown
Опубликована: Дек. 6, 2022
Abstract
Purpose
To
assess
the
efficiency
of
[
68
Ga]GaDOTAFAPI04
in
diagnosing
periprosthetic
hip
joint
infection
and
establish
a
diagnostic
standard
clinical
significance
based
on
uptake
pattern.
Methods
PET/CT
was
performed
patients
with
symptomatic
arthroplasty
from
December
2019
to
July
2022.
The
reference
2018
Evidence-Based
Validation
Criteria.
Two
criteria,
SUVmax
pattern,
were
used
diagnose
PJI.
Meanwhile,
original
data
imported
into
IKT-snap
draw
view
interest,
A.K.
extract
features
cases,
unsupervised
clustering
analysis
applied
according
groups.
Results
A
total
103
included,
28
whom
had
area
under
curve
0.8969,
which
better
than
that
all
serological
tests.
cutoff
value
7.530,
sensitivity
specificity
72%
100%,
respectively.
sensitivity,
accuracy
pattern
93.10%
95%,
In
radiomics
analysis,
PJI
significantly
different
aseptic
failure.
Conclusion
showed
promising
results,
criteria
more
clinically
instructive.
Radiomics
also
certain
application
prospect
field
Trial
registration
number
registration:
ChiCTR2000041204.
Registered
24
September
2019.
Clinical Nuclear Medicine,
Год журнала:
2023,
Номер
48(12), С. e572 - e573
Опубликована: Сен. 21, 2023
Recently
developed
radiolabeled
FAPI
(fibroblast-activation
protein
inhibitors)
have
attracted
researcher's
attention
in
diagnosing
various
tumors
because
of
its
high
specificity
and
better
tumor-to-background
ratio.
Increasing
use
68
Ga-FAPI
PET/CT
has
resulted
reporting
incidental
benign
findings
as
well.
We
hereby
present
a
case
suspected
carcinoma
stomach
showing
increased
uptake
primary
tumor
well
subchondral
cysts
bilateral
shoulder
joints
right
hip
joint
on
PET
CT
scan.
