Does Pizza Consumption Favor an Improved Disease Activity in Rheumatoid Arthritis? DOI Open Access
Roberta De Vito, Maria Parpinel, Michela Carola Speciani

и другие.

Nutrients, Год журнала: 2023, Номер 15(15), С. 3449 - 3449

Опубликована: Авг. 4, 2023

To our knowledge, no studies so far have investigated the role of pizza and its ingredients in modulating disease activity rheumatoid arthritis (RA). We assessed this question via a recent cross-sectional study including 365 participants from Italy, birthplace pizza. Multiple robust linear logistic regression models were fitted with tertile consumption categories each available pizza-related food item/group (i.e., pizza, refined grains, mozzarella cheese, olive oil) as independent variables, RA measure Disease Activity Score on 28 joints C-reactive protein (DAS28-CRP), Simplified Index (SDAI)) dependent variable. Stratified analyses carried out according to severity or duration. Participants eating half >1 time/week (vs. ≤2 times/month) reported beneficial effects activity, significant reductions ~70% (overall analysis), 80% (the more severe stratum), beta coefficients −0.70 for DAS28-CRP, −3.6 SDAI analysis) −1.10 −5.30 (in long-standing RA, respectively). Among items/groups, cheese oil showed effects, especially stratum. Future cohort are needed confirm effect related items/groups activity.

Язык: Английский

Root Canal Infection and Its Impact on the Oral Cavity Microenvironment in the Context of Immune System Disorders in Selected Diseases: A Narrative Review DOI Open Access
Jarosław Sobieszczański, Sebastian Mertowski, Katarzyna Sarna‐Boś

и другие.

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(12), С. 4102 - 4102

Опубликована: Июнь 17, 2023

The oral cavity has a specific microenvironment, and structures such as teeth are constantly exposed to chemical biological factors. Although the structure of is permanent, due exposure pulp root canal system, trauma can have severe consequences cause development local inflammation caused by external opportunistic pathogens. Long-term affect not only periodontal tissues but also functioning immune which trigger systemic reaction. This literature review presents current knowledge on infections their impact microenvironment in context system disorders selected diseases. result analysis statement that periodontal-disease-caused may progression autoimmune diseases rheumatoid arthritis, lupus erythematosus, or Sjogren’s syndrome, well affecting faster conditions occurs as, among others, chronic kidney disease inflammatory bowel disease.

Язык: Английский

Процитировано

9
Effect of Lifestyle Counselling via a Mobile Application on Disease Activity Control in Inflammatory Arthritis: A Single-Blinded, Randomized Controlled Study DOI Open Access
Türker Kurt, Diana Vossen, Falk Schumacher

и другие.

Nutrients, Год журнала: 2024, Номер 16(10), С. 1488 - 1488

Опубликована: Май 14, 2024

Background: Mobile applications (apps) are a resource for information on lifestyle and nutrition which associated to improved outcomes in inflammatory arthritis. Objective: The aim of this study was explore whether targeted counselling via an app improves disease activity arthritis patients. Methods: Patients with rheumatoid (RA), spondyloarthritis (SpA), psoriatic (PsA) were randomized 12 weeks (Mida, Midaia GmbH, Germany) pertaining healthy Mediterranean Diet, physical activity, mental health. Disease measured specific instruments by blinded physician categorized (remission, low, moderate, high). Dietary adherence assessed the Diet Adherence Screener (MEDAS). Mixed effects logistic regression adjusted baseline age, sex calculated. Results: Of 158 patients included (73% female, 53.3 ± 11.7 years), 74 active group (ACG). All showed improvement low or remission. ACG had odds ratio (OR) 2.8 (95%-CI 1.1–7.2, p = 0.035), while OR control not significant 2.1 (0.9–5.0, 0.097). less likely reach MEDAS >= 4 (OR 0.16 (0.03–0.77), 0.02), seen 0.54 (0.06–4.63), 0.6). tendency towards adhesion (MEDAS) (β 0.35 (−0.05–0.74), 0.086). This observed 0.09 (−0.29–0.46), 0.64). Conclusions: Individualized dietary may help improve

Язык: Английский

Процитировано

3
Cellular and Molecular Homeostatic Microenvironmental imbalances in Osteoarthritis and Rheumatoid Arthritis DOI Creative Commons
Constantin Munteanu, Gelu Onose,

Marius-Alexandru Turnea

и другие.

Balneo and PRM Research Journal, Год журнала: 2023, Номер 14(Vol.14, no.2), С. 564 - 564

Опубликована: Июнь 23, 2023

Abstract: Human movement is a complex and multifactorial process due to the interaction between body environment. Movement result of activities all structures that make up joint (i.e., ligaments, tendons, muscles, fascicles, blood vessels, nerves, etc.) control actions nervous system on them. Therefore, many pathological conditions can affect Neu-ro-Myo-Arthro-Kinetic System (NMAK). Osteoarthritis (OA) degenerative form arthritis with high incidence pro-longed course affects articular periarticular tissues such as cartilage, subchondral bone, synovium, degen-erative consequence. Instead, Rheumatoid (RA) an immune-mediated synovial disease caused by genetic environmental factors. This review aims compare Osteoar-thritis Arthritis in terms pathogenesis microenvironment determine main changes regarding immunological defense elements bioenergetics which explain development new thera-peutical opportunities. Keywords: (OA); (RA); Homeostatic imbalances; Microenvironment

Язык: Английский

Процитировано

8
Clinical characteristics of obese patients with adult-onset Still's disease. Data from a large multicentre cohort DOI Creative Commons
Ilenia Di Cola, Daniela Iacono, Ilenia Pantano

и другие.

Joint Bone Spine, Год журнала: 2023, Номер 90(5), С. 105576 - 105576

Опубликована: Апрель 18, 2023

To evaluate the impact of obesity in patients with adult-onset Still's disease (AOSD) and to assess their clinical characteristics outcomes.The features AOSD a body mass index (BMI)≥30 were assessed among those included multicentre Gruppo Italiano di Ricerca Reumatologia Clinica e Sperimentale (GIRRCS) cohort.Out 139 patients, who had BMI registered our database, 26 (18.7%) BMI≥30. A lower rate sore throat (P<0.05), pericarditis pleuritis (P<0.05) was shown obese patients. Additionally, showed higher values C-reactive protein (CRP) ferritin than others. Furthermore, characterised by biologic disease-modifying antirheumatic drug (bDMARD) failure subsequent follow-up (P<0.05). They also presented comorbidity non-obese Finally, predicted presence chronic course both univariate (HR: 1.72, 95%CI: 1.03-2.51, P<0.05) multivariate analyses 1.85, 1.45-2.89, P<0.05). Obesity significant predictor bDMARD 3.03, 1.42-6.45, P<0.01) 3.59, 1.55-8.27, P<0.01).Obese at time diagnosis prevalence throat, serositis, as well CRP ferritin. predictive factor for failure, thus highlighting subset be carefully managed.

Язык: Английский

Процитировано

7
When does obesity exert its effect in conferring risk of developing RA: a large study in cohorts of symptomatic persons at risk DOI Creative Commons
Quirine A Dumoulin, Anna M P Boeren, Doortje I Krijbolder

и другие.

RMD Open, Год журнала: 2024, Номер 10(1), С. e003785 - e003785

Опубликована: Янв. 1, 2024

Objectives Obesity is a known risk factor for developing rheumatoid arthritis (RA). However, it unclear whether obesity exerts its effect during the asymptomatic or symptomatic clinically suspect arthralgia (CSA) phase of risk. To improve understanding on RA development, we aimed to (1) compare body mass index (BMI) at CSA onset BMI general population and (2) study within patients if increases progression RA. Methods 1107 persons from four cohorts (CSA Leiden, Rotterdam, SONAR TREAT EARLIER placebo arm) were studied. For first aim, baseline was compared with age-matched/sex-matched population. Patients stratified anticitrullinated protein antibody (ACPA) status. Regarding second association between inflammatory (IA) development 2 years studied Cox regression analysis each cohort via meta-analysis in all cohorts. Results more often obese than (respectively 21.9% vs 14.0%, 25.7% 14.5%, 26.7% 14.5% 33.3% 14.9%, SONAR, arm). Both ACPA-positive ACPA-negative had higher frequency obesity. Within CSA, not associated IA normal weight (pooled HR 1.01 (95% CI 0.93 1.08)). Conclusions but has already increased Obesity, therefore, presumably an early rather being disease processes that ultimately result clinical arthritis.

Язык: Английский

Процитировано

2
The Associations of Chronotype and Shift Work With Rheumatoid Arthritis DOI Creative Commons
Thomas D. Butler,

J Robert Maidstone,

K Martin Rutter

и другие.

Journal of Biological Rhythms, Год журнала: 2023, Номер 38(5), С. 510 - 518

Опубликована: Июнь 29, 2023

The circadian clock regulates multiple aspects of human physiology including immunity. People have a preference termed chronotype. Those with an evening may be better suited to shift work, but also carry higher risk adverse health. Shift work leads misalignment rhythms and is associated increased inflammatory disease such as asthma cancer. Here, we investigate the association between chronotype, rheumatoid arthritis (RA). associations exposures chronotype on RA were studied in up 444,210 U.K. Biobank participants. Multivariable logistic regression models adjusted for covariates: age, sex, ethnicity, alcohol intake, smoking history, Townsend Deprivation Index (TDI), sleep duration, length working week, body mass index (BMI). After adjusting covariates, individuals morning had lower odds having (RA; ratio [OR]: 0.93, 95% confidence interval [CI]: 0.88-0.99) when compared intermediate chronotypes. persisted more stringent case definition (covariate-adjusted OR: 0.89, CI: 0.81-0.97). When TDI, workers (OR: 1.22, 1.1-1.36) day that attenuated null after further covariate adjustment 1.1, 0.98-1.22). Morning chronotypes permanent night shifts significantly 1.89, 1.19-2.99). These data point role pathogenesis. Further studies are required determine mechanisms underlying this understand potential impact chronic its mediating factors.

Язык: Английский

Процитировано

6
The Clinical Promise of Microalgae in Rheumatoid Arthritis: From Natural Compounds to Recombinant Therapeutics DOI Creative Commons
Edoardo Andrea Cutolo, Roberto Caferri, Rosanna Campitiello

и другие.

Marine Drugs, Год журнала: 2023, Номер 21(12), С. 630 - 630

Опубликована: Дек. 7, 2023

Rheumatoid arthritis (RA) is an invalidating chronic autoimmune disorder characterized by joint inflammation and progressive bone damage. Dietary intervention important component in the treatment of RA to mitigate oxidative stress, a major pathogenic driver disease. Alongside traditional sources antioxidants, microalgae-a diverse group photosynthetic prokaryotes eukaryotes-are emerging as anti-inflammatory immunomodulatory food supplements. Several species accumulate therapeutic metabolites-mainly lipids pigments-which interfere pro-inflammatory pathways involved other inflammatory conditions. The advancement clinical uses microalgae requires continuous exploration phytoplankton biodiversity chemodiversity, followed domestication wild strains into reliable producers said metabolites. In addition, tractability microalgal genomes offers unprecedented possibilities establish microbes light-driven biofactories heterologous immunotherapeutics. Here, we review evidence-based mechanisms metabolites provide detailed coverage genetic engineering strategies enhance yields endogenous compounds develop innovative bioproducts.

Язык: Английский

Процитировано

5
GSK2334470 attenuates high salt-exacerbated rheumatoid arthritis progression by restoring Th17/Treg homeostasis DOI Creative Commons

Qian Mo,

Mansoor Bolideei,

Shan-Jie Rong

и другие.

iScience, Год журнала: 2024, Номер 27(6), С. 109798 - 109798

Опубликована: Апрель 26, 2024

High salt (HS) consumption is a risk factor for multiple autoimmune disorders via disturbing immune homeostasis. Nevertheless, the exact mechanisms by which HS exacerbates rheumatoid arthritis (RA) pathogenesis remain poorly defined. Herein, we found that heightened phosphorylation of PDPK1 and SGK1 upon exposure attenuated FoxO1 expression to enhance glycolytic capacity CD4 T cells, resulting in strengthened Th17 but compromised Treg program. GSK2334470 (GSK), dual PDPK1/SGK1 inhibitor, effectively mitigated HS-induced enhancement overproduction IL-17A. Therefore, administration GSK markedly alleviated HS-exacerbated RA progression collagen-induced (CIA) model. Collectively, our data indicate subverts Th17/Treg homeostasis through PDPK1-SGK1-FoxO1 signaling, while could be viable drug against clinical settings.

Язык: Английский

Процитировано

1
Different gender of oxidative balance score on the risk of rheumatoid arthritis in the US population from NHANES DOI
Fanzhang Meng, Siyi Lu,

Leqing Li

и другие.

International Journal of Rheumatic Diseases, Год журнала: 2024, Номер 27(7)

Опубликована: Июнь 27, 2024

Abstract Background Oxidative stress is associated with risk of pathogenesis between rheumatoid arthritis. The Balance Score (OBS) a systematic tool to assess the effects diet and lifestyle in relation oxidative stress. However, association OBS arthritis has not been reported previously. We conducted cross‐sectional study investigate complex US adults. Methods Overall, 9747 participants were included this study. exposure variable was OBS, which scored by 16 dietary four factors. Multivariate logistic regression, subgroup analysis, restricted cubic spline (RCS) regression used analyze Results Compared lowest quartile group (Q1), multivariate corrected odds ratio (OR) (95% confidence interval [CI]) for highest (Q4) 0.69 (0.52–0.90) ( p = .013 trend); furthermore, RCS showed negative linear relationship According analyses, there significant difference terms gender .049). Conclusion In conclusion, high negatively Gender an effect on RA. Our results suggest that can be as biomarker predict

Язык: Английский

Процитировано

1
Emerging Landscape of In Vitro Models for Assessing Rheumatoid Arthritis Management DOI Creative Commons
Abhay Prakash Mishra, Rajesh Kumar, Seetha Harilal

и другие.

ACS Pharmacology & Translational Science, Год журнала: 2024, Номер 7(8), С. 2280 - 2305

Опубликована: Июль 18, 2024

Rheumatoid arthritis (RA) is a complex condition that influenced by various causes, including immunological, genetic, and environmental factors. Several studies using animal models have documented immune system dysfunction described the clinical characteristics of disease. These provided valuable insights into pathogenesis inflammatory identification new targets for treatment. Nevertheless, none these successfully replicated all RA. Additionally, numerous experimental medications, which were developed based on our enhanced comprehension system's function in RA, shown potential research but ultimately proved ineffective during different stages trials. There been several novel therapy alternatives, do not achieve consistently outstanding therapeutic outcome patients. This underscores importance employing progress

Язык: Английский

Процитировано

1