Demyelination in Patients with POST-COVID Depression
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(16), С. 4692 - 4692
Опубликована: Авг. 9, 2024
Background:
Depression
is
one
of
the
most
severe
sequelae
COVID-19,
with
major
depressive
disorder
often
characterized
by
disruption
in
white
matter
(WM)
connectivity
stemming
from
changes
brain
myelination.
This
study
aimed
to
quantitatively
assess
myelination
clinically
diagnosed
post-COVID
depression
(PCD)
using
recently
proposed
MRI
method,
macromolecular
proton
fraction
(MPF)
mapping.
Methods:
The
involved
63
recovered
COVID-19
patients
(52
mild,
11
moderate,
and
2
severe)
at
13.5
±
10.0
months
post-recovery,
matched
controls
without
prior
history
(n
=
19).
A
group
(PCD,
n
25)
was
identified
based
on
psychiatric
diagnosis,
while
a
comparison
(noPCD,
38)
included
participants
neurological
complications,
excluding
clinical
depression.
Results:
Fast
MPF
mapping
revealed
extensive
demyelination
PCD
patients,
particularly
juxtacortical
WM
(predominantly
occipital
lobe
medial
surface),
tracts
(inferior
fronto-occipital
fasciculus
(IFOF),
posterior
thalamic
radiation,
external
capsule,
sagittal
stratum,
tapetum),
grey
(GM)
structures
(hippocampus,
putamen,
globus
pallidus,
amygdala).
noPCD
also
displayed
notable
demyelination,
but
less
magnitude
propagation.
Multiple
regression
analysis
highlighted
IFOF
as
primary
predictor
Hamilton
scores,
presence,
severity.
number
symptoms
significant
acute
Conclusions:
study,
for
first
time,
reveals
numerous
GM
PCD,
outlining
key
biomarker.
Язык: Английский
Cryotherapy for improvement of cognitive functions and mental wellbeing
Acta Balneologica,
Год журнала:
2024,
Номер
66(4), С. 283 - 290
Опубликована: Янв. 1, 2024
The
possibility
of
improving
cognitive
functions
by
cryostimulation
gathers
increasingly
more
interest
as
the
general
public
becomes
health-oriented
and
populations
many
countries
are
aging.
While
there
is
plenty
research
on
beneficial
effects
physical
health,
disproportionately
less
known
about
its
impact
mental
wellbeing
cognition.
This
review
summarizes
outcomes
currently
available,
up-to-date
studies
this
topic,
to
inspire
future
focused
solidifying
guidelines
limitations
use
for
performance.
topical
yielded
promising
results,
giving
hope
functioning
central
nervous
system
with
cold
exposure,
both
in
healthy
individuals
persons
impairment.
However,
evidence
still
very
limited
unequivocal,
indicating
that
not
all
conditions
can
produce
such
a
effect
different
numbers
sessions
may
be
necessary
depending
recipient’s
sex,
lifestyle,
comorbidities.
mechanism
cryostimulation-induced
improvement
unknown,
proposed
theories
rely
changes
brain-derived
neurotrophic
factor
(BDNF)
concentrations,
parasympathetic
tone,
or
cerebral
oxygenation.
Cryostimulation
potentializes
training,
enhancing
therapeutic
progress
suffering
from
impairment,
well
athletic
performance
physically
active
individuals.
Язык: Английский