Pulmonary and functional hallmarks after SARS-CoV-2 infection across three WHO severity level-groups: an observational study DOI Creative Commons

Patrícia Blau Margosian Conti,

Maria Ângela Gonçalves de Oliveira Ribeiro, Carla Cristina Souza Gomez

и другие.

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Апрель 7, 2025

The manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection range from flu-like symptoms to lung disease. consequences this inflammatory process impact overall function, which can be detected through both short- long-term assessments. This study aimed assess the pulmonary functional and structural characteristics post-SARS-CoV-2 in patients with mild/moderate, severe, critical clinical presentations. An observational, analytical, cross-sectional was conducted between 2020 2022, including participants a confirmed diagnosis disease (COVID)-19, mild/moderate (G1), (G2), (G3) presentations, all evaluated at least 3 months after infection. Spirometry, impulse oscillometry, fractional exhaled nitric oxide (FeNO), chest computed tomography, 6-min walk test (6MWT), hand grip strength, maximum inspiratory pressure, expiratory pressure were assessed. We enrolled 210 aged 18-70 years, 32.6% whom male, older age observed G3. grouped as follows: G1 (42.3%), G2 (25.7%), G3 (31.9%). Percentage predicted X5 differed G2, being higher G1. percentage forced vital capacity (FVC) according Global Lung Function Initiative its z-score FVC by Pereira lower compared volume 1 s (FEV1) also Tiffeneau (FEV1/FVC) index different among groups, increasing severity. flow rate 25-75% (FEF25-75%) FeNO than Chest tomography revealed presence interstitial abnormalities, associated muscle strength evaluation showed an association values G1, but no observed. 6MWT distance covered decreased severity, right-hand Alterations markers post-COVID-19 evaluations, seen These findings highlight complexity assessments, given sequelae consequent impairment capacity.

Язык: Английский

Measuring Post-Exertional Malaise with DePaul Symptom Questionnaires: Challenges and Opportunities DOI Open Access

Leonard A. Jason

OBM Neurobiology, Год журнала: 2025, Номер 09(01), С. 1 - 30

Опубликована: Фев. 5, 2025

Following mental or physical exertion, patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) experience Post-Exertional Malaise (PEM). Although self-report questions represent less expensive and invasive procedures to assess PEM, variability in the wording of symptom can cause reliability validity problems. If different PEM measures are used studies, this could create difficulties replicating findings, identifying biomarkers, determining effective treatments for patients. The objective article is describe challenges opportunities DePaul Symptom Questionnaires (DSQ) specific. five DSQ items identify 97% ME/CFS. A brief DSQ-PEM instrument has now been constructed that consists supplementary such as duration how quickly would recover from activities. more comprehensive called Questionnaire assesses a list triggers length recovery time PEM. In article, we show DSQ’s provide clues ME/CFS pathophysiology well these be outcome measures. Future research should focus on contrasting comparing ways eliciting assessing relationships between questionnaires examining impact treatment trials

Язык: Английский

Процитировано

0
Pulmonary and functional hallmarks after SARS-CoV-2 infection across three WHO severity level-groups: an observational study DOI Creative Commons

Patrícia Blau Margosian Conti,

Maria Ângela Gonçalves de Oliveira Ribeiro, Carla Cristina Souza Gomez

и другие.

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Апрель 7, 2025

The manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection range from flu-like symptoms to lung disease. consequences this inflammatory process impact overall function, which can be detected through both short- long-term assessments. This study aimed assess the pulmonary functional and structural characteristics post-SARS-CoV-2 in patients with mild/moderate, severe, critical clinical presentations. An observational, analytical, cross-sectional was conducted between 2020 2022, including participants a confirmed diagnosis disease (COVID)-19, mild/moderate (G1), (G2), (G3) presentations, all evaluated at least 3 months after infection. Spirometry, impulse oscillometry, fractional exhaled nitric oxide (FeNO), chest computed tomography, 6-min walk test (6MWT), hand grip strength, maximum inspiratory pressure, expiratory pressure were assessed. We enrolled 210 aged 18-70 years, 32.6% whom male, older age observed G3. grouped as follows: G1 (42.3%), G2 (25.7%), G3 (31.9%). Percentage predicted X5 differed G2, being higher G1. percentage forced vital capacity (FVC) according Global Lung Function Initiative its z-score FVC by Pereira lower compared volume 1 s (FEV1) also Tiffeneau (FEV1/FVC) index different among groups, increasing severity. flow rate 25-75% (FEF25-75%) FeNO than Chest tomography revealed presence interstitial abnormalities, associated muscle strength evaluation showed an association values G1, but no observed. 6MWT distance covered decreased severity, right-hand Alterations markers post-COVID-19 evaluations, seen These findings highlight complexity assessments, given sequelae consequent impairment capacity.

Язык: Английский

Процитировано

0