Clinical characteristics and mortality risk factors in pediatric hypertrophic, restrictive, and rapidly progressive hypertrophic cardiomyopathy: a retrospective cohort study with follow-up
Frontiers in Cardiovascular Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Март 31, 2025
Background
Pediatric
cardiomyopathies
are
rare
but
life-threatening
conditions
with
high
mortality.
Limited
data
exists
on
their
clinical
features
and
risk
factors,
especially
in
Asian
populations,
highlighting
the
need
for
further
research
this
area.
Methods
This
retrospective
cohort
study
analyzed
from
212
pediatric
patients
diagnosed
hypertrophic
cardiomyopathy
(HCM),
restrictive
(RCM),
or
phenotype
(RP-HCM)
at
a
single
center
China
October
2012
to
2023,
follow-up
until
31,
2024.
Demographic,
clinical,
diagnostic
data,
as
well
outcomes,
were
reviewed.
Logistic
Cox
regression
models
identified
factors
in-hospital
long-term
Results
Among
patients,
79.72%
(169/212)
had
HCM,
16.98%
(36/212)
RCM,
3.30%
(7/212)
RP-HCM.
Infection
(75.47%,
160/212)
heart
failure
(51.42%,
109/212)
common
comorbidities.
In-hospital
mortality
was
5.19%
(11/212),
of
20.28%
(43/212).
The
independent
included
left
ventricular
ejection
fraction
(LVEF),
pulmonary
hypertension,
low-density
lipoprotein
(LDL)
levels
(
P
<
0.05).
Patients
RP-HCM
showed
poorest
rate
42.86%.
Only
10.4%
(22/212)
underwent
genetic
testing,
yet
positive
detection
63.7%
(14/22).
Conclusions
underscores
importance
early
diagnosis,
integrated
management
cardiomyopathies.
LVEF,
LDL
critical
prognostic
offering
insights
assessment
affected
children.
Язык: Английский
Burden of Congenital Heart Anomalies in North Africa and the Middle East, 1990 to 2021: A Systematic Analysis for the Global Burden of Disease Study 2021
Journal of the American Heart Association,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 16, 2025
Background
Congenital
heart
anomalies
(CHAs)
remain
a
significant
global
health
burden
despite
advances
in
diagnosis
and
management.
Data
on
CHA
North
Africa
the
Middle
East
region
are
scarce.
This
study
aimed
to
estimate
trends
from
1990
2021.
Methods
Results
Using
Global
Burden
of
Disease
Research
2021
database,
we
assessed
incidence,
prevalence,
mortality,
disability‐adjusted
life
years
(DALYs),
stratified
by
age,
sex,
sociodemographic
index
(SDI)
at
regional
national
levels.
Decomposition
analysis
was
used
evaluate
impact
population
growth
incidence.
In
2021,
CHAs
caused
35
272
deaths
(95%
uncertainty
interval
[UI],
28
067–43
670)
3
181
543
DALYs
UI,
2
544
864–3
899
408)
region.
Incidence
prevalence
increased
13%
CI,
10–17)
70%
67–74),
respectively,
whereas
CHA‐related
declined
63%
28–73).
Infants
<12
months
age
accounted
for
74.9%
DALYs,
with
half
occurring
within
first
month.
High‐SDI
countries
had
lowest
middle‐SDI
showed
most
substantial
decline
mortality.
highlighted
that
actual
incidence
is
lower
than
expected
growth.
Conclusions
Although
increased,
mortality
decreased,
particularly
countries.
The
highest
among
infants,
better
outcomes
higher‐SDI
nations.
More
effective
strategies
needed
reduce
preventable
childhood
related
Язык: Английский
Cardiovascular Diseases in Public Health: Chromosomal Abnormalities in Congenital Heart Disease Causing Sudden Cardiac Death in Children
Medicina,
Год журнала:
2024,
Номер
60(12), С. 1976 - 1976
Опубликована: Дек. 1, 2024
Chromosomal
abnormalities
(CAs)
are
changes
in
the
number
or
structure
of
chromosomes,
manifested
as
alterations
total
chromosomes
structural
involving
loss,
duplication,
rearrangement
chromosomal
segments.
CAs
can
be
inherited
occur
spontaneously,
leading
to
congenital
malformations
and
genetic
diseases.
associated
with
cardiovascular
diseases
cause
functional
heart,
affecting
cardiac
chambers,
valves,
coronary
arteries,
aorta,
conduction,
thus
increasing
likelihood
arrhythmias,
arrest,
sudden
death
(SCD).
An
early
diagnosis
adequate
management
essential
prevent
SCD,
which
is
a
serious
public
health
problem
today.
In
our
review,
we
analyzed
responsible
for
heart
disease
(CHD)
that
increase
risk
SCD
prevention
strategies
implemented
reduce
SCD.
Язык: Английский
Congenital heart diseases (CHDs) and forensic investigations: Searching for the cause of death
Experimental and Molecular Pathology,
Год журнала:
2024,
Номер
137, С. 104907 - 104907
Опубликована: Май 30, 2024
Congenital
Heart
Diseases
(CHDs)
are
a
group
of
structural
abnormalities
or
defects
the
heart
that
present
at
birth.
CHDs
could
be
connected
to
sudden
death
(SD),
defined
by
WHO
(World
Health
Organization)
as
"death
occurring
within
24
h
after
onset
symptoms"
in
an
apparently
"healthy"
subject.
These
conditions
can
range
from
relatively
mild
severe,
life-threatening
anomalies.
The
prevalence
varies
across
populations,
but
they
affect
millions
individuals
worldwide.
This
article
aims
discuss
post-mortem
investigation
related
CHDs,
exploring
forensic
approach,
current
methodologies,
challenges,
and
potential
advancements
this
challenging
field.
A
further
goal
is
provide
guide
for
understanding
these
complex
diseases,
highlighting
pivotal
role
autopsy,
histopathology,
genetic
investigations
defining
cause
death,
providing
evidence
about
translational
use
autopsy
reports.
Forensic
play
crucial
complexities
determining
accurately.
Through
collaboration
between
medical
professionals
experts,
meticulous
examinations,
analysis
evidence,
valuable
insights
gained.
not
only
closure
families
affected
also
contribute
prevention
future
tragedies.
Язык: Английский
The molecular mechanisms of cardiac development and related diseases
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Дек. 23, 2024
Cardiac
development
is
a
complex
and
intricate
process
involving
numerous
molecular
signals
pathways.
Researchers
have
explored
cardiac
through
long
journey,
starting
with
early
studies
observing
morphological
changes
progressing
to
the
exploration
of
mechanisms
using
various
biology
methods.
Currently,
advancements
in
stem
cell
technology
sequencing
technology,
such
as
generation
human
pluripotent
cells
organoids,
multi-omics
sequencing,
artificial
intelligence
(AI)
enabled
researchers
understand
better.
Many
regulate
development,
including
growth
transcription
factors
signaling
pathways,
WNT
signaling,
retinoic
acid
Notch
In
addition,
cilia,
extracellular
matrix,
epigenetic
modifications,
hypoxia
conditions
also
play
important
roles
development.
These
crucial
at
one
or
even
multiple
stages
Recent
identified
for
autophagy,
metabolic
transition,
macrophages
Deficiencies
abnormal
expression
these
can
lead
types
abnormalities.
Nowadays,
congenital
heart
disease
(CHD)
management
requires
lifelong
care,
primarily
surgical
pharmacological
treatments.
Advances
techniques
clinical
genetic
testing
earlier
diagnosis
treatment
CHD.
However,
technologies
still
significant
limitations.
The
new
technologies,
AI
will
help
us
better
promote
prevention
CHD
future.
Язык: Английский