Agathisflavone Modulates Reactive Gliosis After Trauma and Increases the Neuroblast Population at the Subventricular Zone
Nutrients,
Год журнала:
2024,
Номер
16(23), С. 4053 - 4053
Опубликована: Ноя. 26, 2024
Background:
Reactive
astrogliosis
and
microgliosis
are
coordinated
responses
to
CNS
insults
pathological
hallmarks
of
traumatic
brain
injury
(TBI).
In
these
conditions,
persistent
reactive
gliosis
can
impede
tissue
repopulation
limit
neurogenesis.
Thus,
modulating
this
phenomenon
has
been
increasingly
recognized
as
potential
therapeutic
approach.
Methods:
study,
we
investigated
the
flavonoid
agathisflavone
modulate
astroglial
microglial
promote
neurogenesis
in
subventricular
zone
(SVZ)
neurogenic
niche.
Agathisflavone,
or
vehicle
controls,
was
administered
directly
into
lateral
ventricles
postnatal
day
(P)8-10
mice
by
twice
daily
intracerebroventricular
(ICV)
injections
for
3
days,
brains
were
examined
at
P11.
Results:
ICV
injection
caused
glial
reactivity
along
needle
track,
characterised
immunohistochemically
increased
astrocyte
expression
fibrillary
protein
(GFAP)
number
Iba-1+
microglia
lesion
site.
Treatment
with
decreased
GFAP
expression,
reduced
both
core
site
penumbra,
induced
a
2-fold
increase
on
ratio
anti-inflammatory
CD206+
pro-inflammatory
CD16/32+
microglia.
Notably,
population
neuroblasts
(GFAP+
type
B
cells)
all
SVZ
microdomains
up
double,
without
significantly
increasing
neuronal
progenitors
(DCX+).
Conclusions:
Although
future
studies
should
investigate
underlying
molecular
mechanisms
driving
effects
polarization
different
timepoints,
data
indicate
that
could
be
adjuvant
treatment
TBI
central
nervous
system
disorders
have
common
feature.
Язык: Английский
Bu Shen Huo Xue Formula Provides Neuroprotection Against Spinal Cord Injury by Inhibits Oxidative Stress by Activating the Nrf2 Signaling Pathway
Drug Design Development and Therapy,
Год журнала:
2024,
Номер
Volume 18, С. 4779 - 4797
Опубликована: Окт. 1, 2024
Spinal
cord
injury
(SCI)
is
an
irreversible
neurological
disease
that
can
result
in
severe
dysfunction.
The
Bu
Shen
Huo
Xue
Formula
(BSHXF)
has
been
clinically
shown
to
assist
the
recovery
of
limb
function
patients
with
SCI.
However,
underlying
mechanisms
BSHXF's
therapeutic
effects
remain
unclear.
This
study
aimed
evaluate
BSHXF
a
mouse
model
SCI
and
identify
potential
targets.
Язык: Английский