The Study of Mono- and Polysubstance Abuse Effects on Complete Blood Count Parameters in Samples of Iraqi Patients

Journal of Applied Hematology, Год журнала: 2024, Номер 15(4), С. 275 - 279

Опубликована: Окт. 1, 2024

Abstract BACKGROUND: Substance abuse represents a major health problem worldwide. In Iraq, the number of substance abusers increased, both single and polysubstance, alcohol medications. Abuse these substances is associated with changes in different blood parameters secondary to their direct immune, inflammatory, toxic stressor effects on hematopoiesis, indirect effect liver kidneys. These involve total white cell (WBC) count, especially lymphocyte count ratio neutrophil platelet (PLT), addition red (RBC) PLT parameters, pancytopenia. OBJECTIVES: We evaluated complete (CBC) parameters. PATIENTS AND METHODS: This study was performed over 6 months 114 participants; 57 them were healthy people from Al-Sadiq Teaching Hospital/Psychiatry Department. A questionnaire used collect demographic data related including type, duration abuse. sample collected participants for CBC assessment. RESULTS: There significant difference between WBC only ( P = 0.004) neutrophil/lymphocyte 0.03). RBC 0.005), mean corpuscular volume 0.008), hemoglobin 0.04), distribution width-standard deviation <0.0001). 0.007), <0.0001), PLT-large PLT/lymphocyte 0.0006). For as well abuse, change involving 0.04). CONCLUSION: Polysubstance misuse widespread samples taken has hematological finding correlated studies worldwide increasing need attention payment follow-up management drug addicts.

Язык: Английский

The therapeutic effect of different cumin essential oil fractions against gastric ulcer in rats

Journal of Food Science, Год журнала: 2024, Номер 90(1)

Опубликована: Дек. 17, 2024

Abstract Cumin, a popular spice, is widely used to treat stomach ailments in Central Asia and Xinjiang, China. Cumin essential oil has been found effectively gastric ulcers, but its pharmacodynamic basis remains unclear. In this study, cumin was directly separated using column chromatography, components were identified through multi‐dimensional gas chromatography‐mass spectrometry. Finally, the fractionated into E1, E2, E3. The effects of these fractions on ulcers studied an anhydrous ethanol‐induced rat model. results indicated that three decreased ulcer index, fluid pH, pepsin activity different extents. They lowered levels prostaglandin gastrin, epidermal growth factor serum. According analysis above indices, E3 fraction had best anti‐ulcer effect. detection oxidative stress inflammatory factors showed all relieved reduced release varying degrees. played most significant role. selected explore relevant mechanism, significantly prevented cleaved caspase‐3 Bax protein resisted apoptosis induced by ethanol injury. western blot for detecting NF‐κB‐related pathway inhibited activation p‐p65, p‐IKKβ, p‐IκBα. study effective effect inhibiting NF‐κB apoptosis, thus reducing inflammation.

Язык: Английский