Evaluating Sensitivity, Specificity, and Optimal Cutoff Scores of the Montreal Cognitive Assessment Using U.S. National Alzheimer Coordinating Centre Uniform Data Set: A Retrospective Analysis of 16,309 Participants DOI Creative Commons
Youssef A. Ismail,

Huda A. Auf,

Shahd A. Sadik

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Окт. 16, 2024

Abstract Background: Neurodegenerative diseases (NDDs) like Alzheimer's disease and Mild Cognitive Impairment are characterized by progressive cognitive decline, with limited effective treatments available. Several screening tools available for diagnosing MCI dementia, including the Rapid Screen, Montreal Assessment (MoCA), Mini-Mental State Examination (MMSE), Dementia Rating Scale (DRS). Objective: This study aims to evaluate sensitivity specificity of MoCA determine its suitability as a diagnostic tool in programs. Methods: The analyzed data from participants aged 55 older, recruited U.S. Disease Research Centers (ADRCs), using National Alzheimer Coordinating Center Uniformed Data Set (NACC-UDS). Participants had an initial diagnosis complete records, focusing on then was followed evaluations classify MCI, or no impairment. Receiver operating characteristic (ROC) analysis used calculate area under curve (AUC). Results: utilized dataset 188,700 participant records NACC. After applying inclusion criteria, 16,309 were included. The information, clinician-conducted assessments, scores. categorized into three groups: 7,624 impairment (NoCI), 4,893 3,792 dementia. focused scores, revealing significant differences among groups (P< 0.001). ROC demonstrated MoCA's strong capability, AUC values significantly above 0.5 (P < Sensitivity calculated at recommended cutoff scores 26 21, while "optimal" identified (< 24) detecting 21) dementia based Youden index reference individuals Although PPV generally low, high NPV across comparisons underscores effectiveness ruling out Conclusion: confirms showing 83% 82% value 21. With 94%, is particularly reliable However, ability identify limited, 52.7%. Despite this, 87% helps reduce false positives supporting overall validity assessment tool.

Язык: Английский

Protective effects of polydatin amphiphilic chitosan nanocarriers against an aluminum chloride-induced model of Alzheimer’s disease in rats: relevance to its anti-inflammatory and antioxidant effects DOI Creative Commons

Seyede Nazanin Zarneshan,

Elham Arkan, Amir Kiani

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Язык: Английский

Процитировано

1
Dementia and Cognitive Decline: A HEALM Approach DOI
Ecler E Jaqua,

Mai-Linh N Tran,

Pedro Álvarez

и другие.

American Journal of Lifestyle Medicine, Год журнала: 2024, Номер unknown

Опубликована: Окт. 9, 2024

Dementia and cognitive decline pose significant global public health challenges, with prevalence expected to rise in the coming decades. Lifestyle medicine offers a promising approach mitigating issues through six key interventions: diet, physical activity, restorative sleep, social connections, stress management, avoiding risky substances. Traditional methods like randomized controlled trials (RCTs) have limitations capturing long-term impacts of these interventions. To overcome American College Medicine (ACLM) True Health Initiative (THI) developed Hierarchies Evidence Applied (HEALM) framework, informed by Threshold Pathway Mapping (ETPM) approach. This framework integrates diverse evidence sources assess intervention effects over time. Applying HEALM, this review evaluates lifestyle factors' impact on dementia decline. It finds strong supporting plant-based nutrition, substances promoting health. Social connections may mitigate decline, while management requires further investigation due inconclusive findings. Integrating findings into strategies could effectively address growing burden enhance overall well-being aging populations, underscoring need for continued research

Язык: Английский

Процитировано

1
Trends in Global Burden of Alzheimer’s Disease and Other Dementias Attributable to High Fasting Plasma Glucose, 1990–2021 DOI Creative Commons
Irena Ilić, Vladimir Jakovljević, Ivana Živanović-Mačužić

и другие.

Medicina, Год журнала: 2024, Номер 60(11), С. 1783 - 1783

Опубликована: Окт. 31, 2024

: Alzheimer's disease and other dementias represent some of the leading public health concerns worldwide. This study aimed to assess global burden attributable high fasting plasma glucose in last decades.

Язык: Английский

Процитировано

1
Evaluating Sensitivity, Specificity, and Optimal Cutoff Scores of the Montreal Cognitive Assessment Using U.S. National Alzheimer Coordinating Centre Uniform Data Set: A Retrospective Analysis of 16,309 Participants DOI Creative Commons
Youssef A. Ismail,

Huda A. Auf,

Shahd A. Sadik

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Окт. 16, 2024

Abstract Background: Neurodegenerative diseases (NDDs) like Alzheimer's disease and Mild Cognitive Impairment are characterized by progressive cognitive decline, with limited effective treatments available. Several screening tools available for diagnosing MCI dementia, including the Rapid Screen, Montreal Assessment (MoCA), Mini-Mental State Examination (MMSE), Dementia Rating Scale (DRS). Objective: This study aims to evaluate sensitivity specificity of MoCA determine its suitability as a diagnostic tool in programs. Methods: The analyzed data from participants aged 55 older, recruited U.S. Disease Research Centers (ADRCs), using National Alzheimer Coordinating Center Uniformed Data Set (NACC-UDS). Participants had an initial diagnosis complete records, focusing on then was followed evaluations classify MCI, or no impairment. Receiver operating characteristic (ROC) analysis used calculate area under curve (AUC). Results: utilized dataset 188,700 participant records NACC. After applying inclusion criteria, 16,309 were included. The information, clinician-conducted assessments, scores. categorized into three groups: 7,624 impairment (NoCI), 4,893 3,792 dementia. focused scores, revealing significant differences among groups (P< 0.001). ROC demonstrated MoCA's strong capability, AUC values significantly above 0.5 (P < Sensitivity calculated at recommended cutoff scores 26 21, while "optimal" identified (< 24) detecting 21) dementia based Youden index reference individuals Although PPV generally low, high NPV across comparisons underscores effectiveness ruling out Conclusion: confirms showing 83% 82% value 21. With 94%, is particularly reliable However, ability identify limited, 52.7%. Despite this, 87% helps reduce false positives supporting overall validity assessment tool.

Язык: Английский

Процитировано

0