Editorial: Weighing the impact of being overweight on female reproductive function and fertility

Frontiers in Reproductive Health, Год журнала: 2025, Номер 7

Опубликована: Фев. 3, 2025

The prevalence of overweight and obesity has followed a growing trend in recent decades worldwide (1). For many years, been considered primarily an aesthetic problem, rather than chronic, serious, relapsing disease. Fortunately, the medical community is increasingly acknowledging that are associated with severe complications, including cardiometabolic disorders, chronic kidney disease, cognitive decline, malignancies, obstructive sleep apnea, urinary incontinence, osteoarthritis, depression, among others (2,3). However, link between female infertility probably one most underestimated aspects increased adiposity. Epidemiological data suggest three-fold higher risk women living compared to normal body weight (4). Although both have lower probability conception, becomes significantly greater as mass index (BMI) increases (5). Available studies long follow-up childhood contributes later life (6). Given high / developing parts world, problem affects high- low-income countries (7); however, limited resources latter make challenge even greater. Insulin resistance, inflammation, coagulation abnormalities, polycystic ovary syndrome (PCOS), disturbances oocyte differentiation maturation proposed potential links two disorders (8). Women may elevated androgen levels absence PCOS, resulting reduced concentrations luteinizing hormone (9). In some cases, itself main source causal mechanisms, while others, it simply represents mediator cascade other negatively affect women's health. several pathophysiological this bidirectional relationship remain poorly understood. Interestingly, reduction shown improve conception (10), underlining need effectively implement loss interventions relevant outcomes.The present research topic includes cutting-edge aims elucidate association reproductive obesity. Sun et al. (11) provided evidence depression mediates weight-adjusted waist secondary infertility, highlighting complex interactions factors contribute impaired fertility Vedelek (12) showed receiving vitro fertilization treatment, reproduction exhibit decreasing increasing BMI, supporting evolutionary selective role nutritional status. Zhang (13) identified altered lipid profile follicular fluid PCOS insulin resistance controls. These could prove useful for future use plasmalogens biomarkers PCOS. Gitsi (14) reviewed current on nutrition exercise improving rates obesity, broad implementation lifestyle treatment disorders. Mendelian randomization study, Xu (15) from NHANES cohort underscoring importance incorporating mental health management strategies into protocols. similar study design, (16) three protein-coding genes (CDCP1, GLRX2, KIRREL2) genetic shedding light abnormalities syndrome. A systematic review meta-analysis by Ren (17) included 25 randomized controlled trials 1,636 various supplements exert beneficial effects markers oxidative stress, hormonal profile. comes important challenges field include better understanding underlying pathogenetic clearer characterization factors, identification prognostic biomarkers, evaluation efficacy safety new anti-obesity drugs, well metabolic surgery, outcomes through well-designed research. Until all these become available, vigilance professionals, but also policy makers societies, required recognize predisposing provide affected evidence-based care support.Acknowledgments: None. Declaration Conflicting Interests: authors report they no conflict interest.Funding: received financial support research, authorship, publication article.

Язык: Английский

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Da NAFLD a MASLD: pillole per endocrinologi

L Endocrinologo, Год журнала: 2025, Номер unknown

Опубликована: Фев. 10, 2025

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Glucagon-like peptide-1 receptor agonists: Exploring the mechanisms from glycemic control to treatment of multisystemic diseases

World Journal of Gastroenterology, Год журнала: 2024, Номер 30(36), С. 4036 - 4043

Опубликована: Сен. 20, 2024

This editorial takes a deeper look at the insights provided by Soresi and Giannitrapani, which examined therapeutic potential of glucagon-like peptide-1 receptor agonists (GLP-1RAs) for metabolic dysfunction-associated fatty liver disease. We provide supplementary to their research, highlighting broader systemic implications GLP-1RAs, synthesizing current understanding mechanisms trajectory research in this field. GLP-1RAs are revolutionizing treatment type 2 diabetes mellitus beyond. Beyond glycemic control, demonstrate cardiovascular renal protective effects, offering managing diabetic kidney disease al-ongside renin–angiotensin–aldosterone system inhibitors. Their role bone metabolism hints benefits osteoporosis, while neuroprotective properties show promise Alzheimer's modulating neuronal insulin signaling. Additionally, they improve hormonal profiles polycystic ovary syndrome. highlights multifaceted emphasizing need ongoing fully realize across range multisystemic diseases.

Язык: Английский

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Association between nonalcoholic fatty liver disease and infertility in reproductive-aged females

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Context: Findings from observational studies indicate association between non-alcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome. However, the relationship NAFLD female infertility remains unclear. Objective: This study aimed to evaluate associations at phenotypic genetic levels. Methods: Cross-sectional analysis using 2013-2018 2017-2020 (pre-pandemic) National Health Nutrition Examination Survey (NHANES) was performed. defined by utilizing Hepatic Steatosis Index (HSI), median value of controlled attenuation parameter (CAP)and stiffness measurement (LSM). Multivariable logistic regression subgroup analyses were used examine related indicesand infertility. Subgroup explore whether HSI values influenced potential confounders. A bidirectional, two-sample Mendelian randomization determine causal Results: Higher associated with progressively higher odds in women. Increasing CAP LSM positively an increased risk There interaction age indices relation prevalence In MR analyses, IVW method showed no genetically Conclusion: Reproductive-aged women may have U.S. however, findings did not a

Язык: Английский

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