Ketogenic Diets for Body Weight Loss: A Comparison with Other Diets

Nutrients, Год журнала: 2025, Номер 17(6), С. 965 - 965

Опубликована: Март 10, 2025

With the prevalence of obesity and overweight increasing at an alarming rate, more researchers are focused on identifying effective weight loss strategies. The ketogenic diet (KD), used as a treatment in epilepsy management for over 100 years, is additionally gaining popularity method. Although its efficacy well documented, areas where it may be beneficial to other dietary approaches need carefully examined. objective this paper identify potential benefits KD alternative strategies based comprehensive literature review. It has been shown that bioenergetically efficient than strategies, inter alia owing effect curtailing hunger, improving satiety decreasing appetite (influence hunger hormones sensation hunger), inducing faster initial (associated with lower glycogen levels reduced water retention), controlling glycaemia insulinemia (directly attributable low-carbohydrate nature indirectly described). These effects accompanied by improved insulin sensitivity, inflammation (through ketone bodies avoidance pro-inflammatory sugars), pharmacological control (the diet’s mechanisms similar those medication but without side effects), positive impacts psychological factors food addiction. Based authors’ review latest research, reasonable conclude that, due these many additional health benefits, advantageous diet-based This important hypothesis deserves further exploration, which could achieved including outcome measures future clinical trials, especially when comparing different diets equal caloric value.

Язык: Английский

---

Artificial Intelligence‐Based Diets: A Role in the Nutritional Treatment of Metabolic Dysfunction‐Associated Steatotic Liver Disease?

Journal of Human Nutrition and Dietetics, Год журнала: 2025, Номер 38(2)

Опубликована: Фев. 27, 2025

ABSTRACT Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a growing global health concern. Effective management of this condition relies heavily on lifestyle modifications and dietary interventions. In study, we sought to evaluate the plans for MASLD generated by ChatGPT (GPT‐4o) according current guideline recommendations. Methods was used create single‐day meal 48 simulated patients with MASLD, tailored individual characteristics such as age, gender, height, weight transient elastography parameters. The were assessed appropriateness disease‐specific guidelines. Results mean energy content menus planned 1596.9 ± 141.5 kcal accuracy 91.3 11.0%, fibre 22.0 0.6 g 88.1 2.5%. However, they exhibited elevated levels protein, fat saturated acids. Conversely, carbohydrate lower. recommended loss obese but did not extend advice normal‐weight overweight individuals. Notably, recommendations Mediterranean diet physical activity absent. Conclusions shows potential in developing management. discrepancies macronutrient distributions omission key evidence‐based highlight need further refinement. To enhance effectiveness AI tools recommendations, alignment established guidelines must be improved.

Язык: Английский

---

Ketogenic Diet in Steatotic Liver Disease: A Metabolic Approach to Hepatic Health

Nutrients, Год журнала: 2025, Номер 17(7), С. 1269 - 1269

Опубликована: Апрель 4, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major cause of chronic dysfunction worldwide, characterized by hepatic steatosis that may progress to nonalcoholic steatohepatitis and cirrhosis. Owing its strong association with metabolic disorders, current management focuses on weight reduction via lifestyle modifications. Recently, the very-low-calorie ketogenic diet (VLCKD) has emerged as promising intervention due potential for rapid loss in fat. This review aims evaluate clinical evidence regarding impact diets steatosis. We conducted an extensive MEDLINE literature search databases including PubMed, Scopus, Web Science up December 2024. Studies assessing effects or low-carbohydrate high-fat fat, evaluated imaging, histology, biochemical markers, were included. The analysis indicates significantly reduce fat content improve parameters, insulin sensitivity enzyme levels. Evidence further suggests substituting saturated fats unsaturated replacing carbohydrates proteins enhance these benefits. However, considerable variability exists among studies long-term data remain limited. Although short-term outcomes are encouraging, adverse such dyslipidaemia, gastrointestinal disturbances, transient 'keto flu' symptoms require careful monitoring. Future research should focus elucidating underlying mechanisms, optimizing dietary composition, safety establish robust strategy managing MASLD.

Язык: Английский

---

The Impact of a Ketogenic Diet on Late-Stage Pancreatic Carcinogenesis in Mice: Efficacy and Safety Studies

Nutrients, Год журнала: 2024, Номер 16(22), С. 3919 - 3919

Опубликована: Ноя. 16, 2024

High-fat diets (HFDs) have been associated with an increased risk of pancreatic cancer. In contrast, ketogenic (KDs) shown to display anti-tumor characteristics. The objective this work was evaluate the efficacy a KD on late-stage carcinogenesis in genetically modified mouse model cancer [LSL-

Язык: Английский

---

Bilirubin, a hepatoprotective agent that activates SIRT1, PGC-1α, and PPAR-α, while inhibiting NF-κB in rats with metabolic-associated fatty liver disease

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Ноя. 25, 2024

Metabolic-associated fatty liver disease (MAFLD) is a chronic disorder characterized by alongside overweight or obesity and/or type 2 diabetes mellitus (T2DM). Timely intervention crucial for potential cure. This study aimed to investigate the effects of bilirubin, an endogenous antioxidant, on lipid metabolism and inflammation in MAFLD. Specifically, it examined bilirubin's impact SIRT1, PPAR-α, NF-κB livers rats with MAFLD induced high-fat diet (HFD) streptozotocin (STZ) administration. Forty eight-week adult male Sprague Dawley were divided into five groups (n = 8): Control, HFD-STZ, HFD-S-BR6, HFD-S-BR14, C-BR14. In last three groups, bilirubin administration was performed intraperitoneally 6 14 weeks (10 mg/kg/day). We selected key genes associated subsequently GO (Gene Ontology) KEGG (Kyoto Encyclopedia Genes Genomes) analyses explore enriched biological processes signaling pathways. Hence, gene expression PGC-1α, inflammatory (NF-κB, TNF-α, IL-6, IL-1β) measured using Real-time quantitative PCR. Stereological histopathological alterations structure as well profile, biochemical indices, also assessed among different groups. The enrichment analysis identified that several pathways might be related Bilirubin-treated contained higher SIRT1 levels approximately 5.7-, 2.1-, 2.2-fold, respectively, compared HFD-receiving (p < 0.0001, p 0.05, 0.05). Whereas, involved cascades, including NF-κB, downregulated 0.6-fold 0.05) following 14-week treatment while only significantly decreased IL-6 (approximately 0.6-fold, observed after 6-week bilirubin. Remarkably, favorably reversed HFD liver's volume cell numbers ameliorated structural changes. It improved parameters, indices HFD-STZ rats. indicated acts protective/ameliorative compound against MAFLD, particularly through regulating

Язык: Английский

---

A Ketogenic Diet Followed by Gradual Carbohydrate Reintroduction Restores Menstrual Cycles in Women with Polycystic Ovary Syndrome with Oligomenorrhea Independent of Body Weight Loss: Results from a Single-Center, One-Arm, Pilot Study

Metabolites, Год журнала: 2024, Номер 14(12), С. 691 - 691

Опубликована: Дек. 8, 2024

: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of fertile age. Some studies suggest that ketogenic diet (KD) may have role treating PCOS. We aimed to demonstrate the long-term effectiveness KD

Язык: Английский

---