The Need for Standardized Guidelines for the Use of Monocyte Distribution Width (MDW) in the Early Diagnosis of Sepsis DOI Open Access
Andrea Piccioni,

Fabio Spagnuolo,

Silvia Baroni

и другие.

Journal of Personalized Medicine, Год журнала: 2024, Номер 15(1), С. 5 - 5

Опубликована: Дек. 27, 2024

Sepsis is a complex and potentially life-threatening syndrome characterized by an abnormal immune response to infection, which can lead organ dysfunction, septic shock, death. Early diagnosis crucial improving prognosis reducing hospital management costs. This narrative review aims summarize evaluate the current literature on role of monocyte distribution width (MDW) as diagnostic biomarker for sepsis, highlighting its advantages, limitations, potential clinical applications. MDW measures volumetric monocytes, reflecting monocytic anisocytosis, detected using advanced hematological analyzers. In 2019, it was approved FDA sepsis due ability identify systemic inflammatory at early stage. Thirty-one studies analyzed us have shown that increased value associated with higher risk combination parameters (such qSOFA) other biomarkers (CRP, PCT) enhance sensitivity stratification capacity. Despite high sensitivity, has lower specificity compared more established such procalcitonin, thus requiring multimodal integration accurate diagnosis. The use in emergency intensive care settings represents opportunity improve critical patient management, particularly when combined markers tools. However, further are needed define universal cut-off confirm validity different contexts pathological scenarios.

Язык: Английский

The Need for Standardized Guidelines for the Use of Monocyte Distribution Width (MDW) in the Early Diagnosis of Sepsis DOI Open Access
Andrea Piccioni,

Fabio Spagnuolo,

Silvia Baroni

и другие.

Journal of Personalized Medicine, Год журнала: 2024, Номер 15(1), С. 5 - 5

Опубликована: Дек. 27, 2024

Sepsis is a complex and potentially life-threatening syndrome characterized by an abnormal immune response to infection, which can lead organ dysfunction, septic shock, death. Early diagnosis crucial improving prognosis reducing hospital management costs. This narrative review aims summarize evaluate the current literature on role of monocyte distribution width (MDW) as diagnostic biomarker for sepsis, highlighting its advantages, limitations, potential clinical applications. MDW measures volumetric monocytes, reflecting monocytic anisocytosis, detected using advanced hematological analyzers. In 2019, it was approved FDA sepsis due ability identify systemic inflammatory at early stage. Thirty-one studies analyzed us have shown that increased value associated with higher risk combination parameters (such qSOFA) other biomarkers (CRP, PCT) enhance sensitivity stratification capacity. Despite high sensitivity, has lower specificity compared more established such procalcitonin, thus requiring multimodal integration accurate diagnosis. The use in emergency intensive care settings represents opportunity improve critical patient management, particularly when combined markers tools. However, further are needed define universal cut-off confirm validity different contexts pathological scenarios.

Язык: Английский

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