Chronic Obstructive Pulmonary Disease and Type 2 Diabetes Mellitus: Complex Interactions and Clinical Implications
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(6), С. 1809 - 1809
Опубликована: Март 7, 2025
Chronic
obstructive
pulmonary
disease
(COPD)
and
type
2
diabetes
mellitus
(T2DM)
are
highly
prevalent
chronic
conditions,
frequently
coexisting
due
to
their
shared
pathophysiological
mechanisms
risk
factors.
Epidemiological
studies
estimate
that
up
30%
of
COPD
patients
have
comorbid
T2DM,
contributing
worsened
progression,
more
hospitalizations,
higher
mortality
rates.
Systemic
inflammation
in
contributes
insulin
resistance
by
increasing
pro-inflammatory
cytokines
(TNF-α,
IL-6,
CRP),
which
impair
glucose
metabolism
beta-cell
function.
Conversely,
hyperglycemia
T2DM
exacerbates
oxidative
stress,
leading
endothelial
dysfunction,
reduced
lung
function,
impaired
repair
mechanisms.
A
comprehensive
narrative
review
was
conducted
evaluate
the
interplay
between
examining
mechanisms,
clinical
consequences,
management
strategies.
The
co-occurrence
accelerates
development,
elevates
hospitalization
rates,
deteriorates
overall
prognosis.
Pharmacological
interactions
complicate
illness
treatment,
requiring
a
multidisciplinary
therapy
strategy.
Recent
data
underscore
need
integrate
palliative
care,
facilitate
decision-making,
provide
psychological
support
enhance
patient
outcomes.
Efficient
COPD-T2DM
comorbidity
necessitates
customized,
interdisciplinary
strategy
targets
both
respiratory
metabolic
health.
Preliminary
prognostic
dialogues,
holistic
lifestyle
modifications
can
improve
quality
life
results.
Язык: Английский
The Role of Inflammation in the Pathogenesis of Comorbidity of Chronic Obstructive Pulmonary Disease and Pulmonary Tuberculosis
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(6), С. 2378 - 2378
Опубликована: Март 7, 2025
The
comorbid
course
of
chronic
obstructive
pulmonary
disease
(COPD)
and
tuberculosis
is
an
important
medical
social
problem.
Both
diseases,
although
having
different
etiologies,
have
many
overlapping
relationships
that
mutually
influence
their
prognosis.
aim
the
current
review
to
discuss
role
immune
mechanisms
underlying
inflammation
in
COPD
tuberculosis.
These
are
known
involve
both
innate
adaptive
system,
including
various
cellular
intercellular
interactions.
There
growing
evidence
involved
pathogenesis
may
jointly
contribute
tuberculosis-associated
(TOPD)
phenotype.
Several
studies
reported
prior
as
a
risk
factor
for
COPD.
Therefore,
study
link
considerable
clinical
interest.
Язык: Английский