Expression of MMP-14 and CD147 in Gingival Tissue of Patients With and Without Diabetes Mellitus Type II DOI Creative Commons

Ionuț Cătălin Botezatu,

Maria-Alexandra Mârțu,

Laura Stoica

и другие.

Diagnostics, Год журнала: 2025, Номер 15(5), С. 609 - 609

Опубликована: Март 3, 2025

Background: Diabetes mellitus (DM) is a major risk factor for the development of periodontal disease and aggravates severity conditions. Matrix metalloproteinases (MMPs) are known to degrade ligament attachment bone matrix proteins. Increased expression CD147 associated with increased synthesis several MMPs, being modulator MMP expression, including that MMP-14. The purpose this study was quantify compare expressions MMP-14 in gingival tissues patients without type 2 diabetes mellitus. Material Methods: In histological study, we included 33 subjects disease: 16 DM (test group) 17 systemically healthy (control group). Tissue fragments were processed using an immunohistochemistry technique determine immunoreactivity (IR) intensity CD147. Results: group periodontitis, 56.2% showed weak positive (+), while 43.8% had intensely (+++) Statistically significant differences between test control groups (p = 0.004, p 0.883, 0.002) found membranous IR moderate (++) CD 147, (+++). 0.001, 0.002, 0.003) Conclusions: significantly higher 147 demonstrates role these biomarkers pathology patients. It can be assumed could further investigated as potential predictive biomarkers.

Язык: Английский

Expression of MMP-14 and CD147 in Gingival Tissue of Patients With and Without Diabetes Mellitus Type II DOI Creative Commons

Ionuț Cătălin Botezatu,

Maria-Alexandra Mârțu,

Laura Stoica

и другие.

Diagnostics, Год журнала: 2025, Номер 15(5), С. 609 - 609

Опубликована: Март 3, 2025

Background: Diabetes mellitus (DM) is a major risk factor for the development of periodontal disease and aggravates severity conditions. Matrix metalloproteinases (MMPs) are known to degrade ligament attachment bone matrix proteins. Increased expression CD147 associated with increased synthesis several MMPs, being modulator MMP expression, including that MMP-14. The purpose this study was quantify compare expressions MMP-14 in gingival tissues patients without type 2 diabetes mellitus. Material Methods: In histological study, we included 33 subjects disease: 16 DM (test group) 17 systemically healthy (control group). Tissue fragments were processed using an immunohistochemistry technique determine immunoreactivity (IR) intensity CD147. Results: group periodontitis, 56.2% showed weak positive (+), while 43.8% had intensely (+++) Statistically significant differences between test control groups (p = 0.004, p 0.883, 0.002) found membranous IR moderate (++) CD 147, (+++). 0.001, 0.002, 0.003) Conclusions: significantly higher 147 demonstrates role these biomarkers pathology patients. It can be assumed could further investigated as potential predictive biomarkers.

Язык: Английский

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