Oxidative Medicine and Cellular Longevity,
Год журнала:
2021,
Номер
2021(1)
Опубликована: Янв. 1, 2021
Sestrin2
is
a
stress‐inducible
metabolic
regulator
and
conserved
antioxidant
protein
which
has
been
implicated
in
the
pathogenesis
of
several
diseases.
can
protect
against
atherosclerosis,
heart
failure,
hypertension,
myocardial
infarction,
stroke,
spinal
cord
injury
neurodegeneration,
nonalcoholic
fatty
liver
disease
(NAFLD),
fibrosis,
acute
kidney
(AKI),
chronic
(CKD),
pulmonary
inflammation.
Oxidative
stress
cellular
damage
signals
alter
expression
to
compensate
for
organ
damage.
Different
such
as
those
mediated
by
P53,
Nrf2/ARE,
HIF‐1
α
,
NF‐
κ
B,
JNK/c‐Jun,
TGF‐
β
/Smad
signaling
pathways
induce
expression.
Subsequently,
activates
Nrf2
AMPK.
Furthermore,
major
negative
mTORC1.
indirectly
regulates
genes
reprograms
intracellular
attenuate
oxidative
modulate
large
number
events
synthesis,
cell
energy
homeostasis,
mitochondrial
biogenesis,
autophagy,
mitophagy,
endoplasmic
reticulum
(ER)
stress,
apoptosis,
fibrogenesis,
lipogenesis.
vigorously
enhances
M2
macrophage
polarization,
attenuates
inflammation,
prevents
death.
These
alterations
molecular
levels
improve
clinical
presentation
This
review
will
shed
light
on
beneficial
effects
diseases
with
an
emphasis
underlying
pathophysiological
effects.
International Journal of Molecular Sciences,
Год журнала:
2019,
Номер
20(4), С. 874 - 874
Опубликована: Фев. 18, 2019
The
latest
studies
have
indicated
a
strong
relationship
between
systemic
insulin
resistance
(IR)
and
higher
incidence
of
neurodegeneration,
dementia,
mild
cognitive
impairment.
Although
some
these
abnormalities
could
be
explained
by
chronic
hyperglycaemia,
hyperinsulinemia,
dyslipidaemia,
and/or
prolonged
whole-body
inflammation,
the
key
role
is
attributed
to
neuronal
redox
imbalance
oxidative
damage.
In
this
mini
review,
we
provide
schematic
overview
intracellular
stress
mitochondrial
in
IR
brain.
We
highlight
important
correlations
found
so
far
brain
stress,
ceramide
generation,
β-amyloid
accumulation,
as
well
apoptosis
conditions.
Antioxidants,
Год журнала:
2020,
Номер
9(5), С. 450 - 450
Опубликована: Май 23, 2020
Periodontitis
is
inextricably
linked
to
oxidative-reductive
(redox)
imbalance.
However,
little
still
known
about
the
resultant
ability
scavenge
oxygen
free
radicals
in
saliva
and
gingival
crevicular
fluid
patients
with
periodontitis.
The
multitude
of
enzymatic
non-enzymatic
antioxidants
their
synergistic
effects
cause
an
interest
evaluation
total
antioxidative
capacity.
Thus,
our
study
aimed
evaluate
oxidative
activity
periodontitis,
as
well
relate
these
biomarkers
clinical
indices
periodontopathy.
Additionally,
by
calculating
stress
index
(OSI),
intensity
redox
disturbances
was
also
evaluated.
Fifty-eight
periodontitis
were
included
divided
into
two
subgroups
depending
on
severity
disease.
In
non-stimulated/stimulated
a
group,
we
found
significantly
higher
OSI
oxidant
status
(TOS)
lower
antioxidant
capacity
(TAC).
reduce
iron
ions
(FRAP)
only
stimulated
non-stimulated
examined
parameters
correlated
periodontium’s
condition,
which
indicates
exacerbation
inflammatory
process.
TAC,
TOS,
OSI,
FRAP
did
not
differentiate
individual
stages
BioMed Research International,
Год журнала:
2021,
Номер
2021, С. 1 - 8
Опубликована: Март 29, 2021
Polygonatum
sibiricum
polysaccharides
(PSP),
the
extract
of
sibiricum,
are
demonstrated
to
exhibit
a
wide
range
pharmacological
activities.
A
recent
study
reported
that
PSP
alleviated
aging
kidney
and
meninges.
However,
effect
on
heart
remains
unclear.
The
present
is
aimed
at
investigating
protection
D-galactose-
(D-gal-)
induced
aging.
Results
showed
irregularly
arranged
cardiac
muscle
fibers
were
observed
in
tissues
D-gal-treated
mice,
levels
troponin
T
(cTnT),
creatine
kinase
(CK),
p21,
p53
increased
after
D-gal
treatment.
D-gal-induced
injury
can
be
attenuated
by
oral
administration
PSP.
Moreover,
also
decreased
reactive
oxygen
species
(ROS)
malondialdehyde
(MDA)
level
superoxide
dismutase
(SOD)
hearts
mice.
DNA
damages
lipid
peroxidation
oxidative
stress
inhibited
as
indicated
reduced
8-hydroxydeoxyguanosine
(8-OHdG)
4-hydroxy-2-nonenal
(4-HNE).
Collectively,
via
inhibiting
stress,
suggesting
might
serve
potential
effective
Chinese
herbal
active
constituent
for
antiaging
therapy.
Journal of Clinical Medicine,
Год журнала:
2020,
Номер
9(3), С. 837 - 837
Опубликована: Март 19, 2020
Oxidative
stress
plays
a
critical
role
in
the
pathogenesis
of
hypertension;
however,
there
are
no
data
on
salivary
redox
homeostasis
and
gland
function
children
with
hypertension.
A
total
53
hypertension
age-
sex-matched
controls
were
classified
for
study.
The
antioxidant
barrier
oxidative/nitrosative
evaluated
non-stimulated
(NWS)
stimulated
(SWS)
whole
saliva,
plasma,
erythrocytes,
Student’s
t-test
Mann–Whitney
U-test
used
statistical
analysis.
We
demonstrated
that
activities
superoxide
dismutase,
catalase,
peroxidase
significantly
higher
NWS,
SWS,
erythrocytes
hypertension,
similar
to
oxidative
damage
proteins
(advanced
glycation
end
products)
lipids
(malondialdehyde)
as
well
nitrosative
markers
(peroxynitrite
nitrotyrosine).
level
uric
acid
(UA)
was
plasma
UA
concentration
SWS
correlated
positively
systolic
diastolic
blood
pressure
content
plasma.
This
parameter
differentiates
from
healthy
(AUC
=
0.98)
high
degree
sensitivity
(94%)
specificity
(94%).
Stimulated
flow
lower
group,
protein
amylase
activity.
In
summary,
childhood
is
associated
hyposalivation
disturbances
defense
enhanced
both
plasma/erythrocytes
saliva.
Salivary
may
be
potential
biomarker
children.
Oxidative Medicine and Cellular Longevity,
Год журнала:
2022,
Номер
2022, С. 1 - 19
Опубликована: Ноя. 16, 2022
Acute
ischemic
stroke
is
a
serious
life-threatening
disease
that
affects
almost
600
million
people
each
year
throughout
the
world
with
mortality
of
more
than
10%,
while
two-thirds
survivors
remain
disabled.
However,
available
treatments
for
are
still
limited
to
thrombolysis
and/or
mechanical
thrombectomy,
and
there
an
urgent
need
developing
new
therapeutic
target.
Recently,
intravascular
oxidative
stress,
derived
from
endothelial
cells,
platelets,
leukocytes,
has
been
found
be
tightly
associated
stroke-related
thrombosis.
It
not
only
promotes
primary
thrombus
formation
by
damaging
cells
platelets
but
also
maturation
stability
modifying
fibrin
components.
Thus,
stress
expected
novel
target
prevention
treatment
stroke.
In
this
review,
we
first
discuss
mechanisms
which
thrombosis,
then
summarize
biomarkers
finally
put
forward
antithrombotic
therapy
targeting
in
Current Heart Failure Reports,
Год журнала:
2022,
Номер
19(6), С. 400 - 411
Опубликована: Окт. 20, 2022
Abstract
Purpose
of
Review
Sarcopenia
and
frailty
are
common
in
patients
with
heart
failure
(HF)
strongly
associated
prognosis.
This
review
aims
to
examine
promising
biomarkers
that
can
guide
physicians
identifying
sarcopenia
HF.
Recent
Findings
Traditional
including
C-reactive
protein,
aminotransaminase,
myostatin,
urinary
creatinine
as
well
novel
microRNAs,
suppression
tumorigenicity
2
(ST2),
galectin-3,
procollagen
type
III
N-terminal
peptide
may
help
predicting
the
development
HF
patients.
Among
those
biomarkers,
aminotransferase,
creatinine,
ST2
predicted
prognosis
frailty.
Summary
outlines
current
knowledge
considered
for
diagnosing
The
listed
might
support
diagnosis,
prognosis,
therapeutic
decisions
Journal of Clinical Medicine,
Год журнала:
2020,
Номер
9(4), С. 976 - 976
Опубликована: Апрель 1, 2020
This
is
the
first
study
to
evaluate
both
antioxidant
barrier,
glutathione
metabolism,
and
oxidative
damage
proteins
lipids
in
morbidly
obese
patients
undergoing
bariatric
treatment.
The
included
65
with
class
3
obesity
divided
into
two
subgroups:
without
metabolic
syndrome
(OB)
(OB
+
MS).
Blood
samples
were
collected
before
surgery
as
well
one,
three,
six,
twelve
months
after
Superoxide
dismutase
reduced
(GSH)
significantly
decreased,
whereas
reductase
uric
acid
enhanced
compared
lean
control.
Moreover,
OB
group,
we
observed
increase
of
superoxide
(SOD)
decrease
(UA)
treatment;
however,
these
changes
not
MS
group.
(advanced
glycation
end
products,
AGE;
advanced
oxidation
protein
AOPP)
(8-isoprostanes,
8-isop;
4-hydroxynoneal)
was
higher
patients.
We
noticed
that
AGE
AOPP
levels
diminished
treatment,
redox
status
(ratio
GSH
oxidized
glutathione)
still
Summarizing,
morbid
associated
disturbances
barrier
lipids.
Although
improves
homeostasis
patients,
those
show
a
continuous
status.
In
supplementation
may
be
considered.
Oxidative Medicine and Cellular Longevity,
Год журнала:
2021,
Номер
2021(1)
Опубликована: Янв. 1, 2021
Cerebral
stroke
is
a
serious
worldwide
health
problem,
as
can
be
seen
by
the
global
epidemic
of
disease.
In
this
disorder,
when
blood
flow
compromised
ruptures
or
blocked
arteries,
sudden
death
neurons
observed
result
lack
oxygen
and
nutrients.
Numerous
severe
problems
frequent
complications
also
exist
in
patients;
therefore,
there
an
urgent
need
to
develop
new
therapeutic,
diagnostic,
prognostic
methods
for
At
present,
diagnosis
based
on
neurological
examination,
medical
history,
neuroimaging,
due
fact
that
rapid
noninvasive
diagnostic
tests
are
unavailable.
Nevertheless,
oxidative
stress
inflammation
considered
key
factors
pathogenesis.
Oxygen
free
radicals
responsible
oxidation
lipids,
proteins,
DNA/RNA,
which
turn
contributes
damage
brain.
Toxic
products
reactions
act
cytostatically
cell
damaging
membranes
leading
neuronal
apoptosis
necrosis.
Thus,
it
seems
redox/inflammatory
biomarkers
might
used
Nowadays,
saliva
increasing
interest
clinical
laboratory
medicine.
Redox
could
obtained
easily,
noninvasively,
cheaply,
stress‐free
from
saliva.
This
minireview
aimed
at
presenting
current
knowledge
concerning
use
salivary
prognosis
stroke.
Cardiovascular Research,
Год журнала:
2024,
Номер
120(9), С. 982 - 998
Опубликована: Июнь 1, 2024
Abstract
In
an
ageing
society,
the
importance
of
maintaining
healthy
life
expectancy
has
been
emphasized.
As
a
result
age-related
decline
in
functional
reserve,
frailty
is
state
increased
vulnerability
and
susceptibility
to
adverse
health
outcomes
with
serious
impact
on
expectancy.
The
skeletal
muscle
mass
function,
also
known
as
sarcopenia,
key
development
physical
frailty.
Both
sarcopenia
are
highly
prevalent
patients
not
only
advanced
age
but
illnesses
that
exacerbate
their
progression
like
heart
failure
(HF),
cancer,
or
dementia,
prevalence
HF
reaching
up
50–75%
19.5–47.3%,
respectively,
resulting
1.5–3
times
higher
1-year
mortality.
biological
mechanisms
multifactorial,
complex,
yet
fully
elucidated,
ranging
from
DNA
damage,
proteostasis
impairment,
epigenetic
changes
mitochondrial
dysfunction,
cellular
senescence,
environmental
factors,
many
which
further
linked
cardiac
disease.
Currently,
there
no
gold
standard
for
treatment
however,
growing
evidence
supports
combination
exercise
training
nutritional
supplement
improves
function
frailty,
variety
other
therapies
being
devised
based
underlying
pathophysiology.
this
review,
we
address
involvement
disease
describe
latest
insights
into
well
potential
intervention
through
exercise,
diet,
specific
therapies.
