Developments in diagnostic applications of saliva in human organ diseases

Medicine in Novel Technology and Devices, Год журнала: 2022, Номер 13, С. 100115 - 100115

Опубликована: Янв. 19, 2022

Saliva is one of the important body fluids that reflects normal internal characteristics and disease state an individual. As a multi-composition oral fluid, has high potential for surveillance general health disease, which contains various signal biomarkers non-invasive, convenient, fast easy to be accepted by patients. At present, saliva increasingly used as biological fluid diagnosis, monitoring systemic states predicting progression, been verified. In this review, molecular compositions effectiveness reliable were discussed. Besides latest research progress in diagnosis related 14 organs reviewed. The factors affecting method improve accuracy prediction through artificial intelligence combined with microfluidic chip was proposed, laid foundation dealing prevention, treatment diseases great long-term significance.

Язык: Английский

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Pathophysiology and Therapeutic Potential of NADPH Oxidases in Ischemic Stroke-Induced Oxidative Stress

Oxidative Medicine and Cellular Longevity, Год журнала: 2021, Номер 2021(1)

Опубликована: Янв. 1, 2021

Stroke is a leading cause of death and disability in humans. The excessive production reactive oxygen species (ROS) an important contributor to oxidative stress secondary brain damage after stroke. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, enzyme complex consisting membrane subunits cytoplasmic subunits, regulates neuronal maturation cerebrovascular homeostasis. However, NADPH oxidase overproduction contributes neurotoxicity disease. has been implicated as the principal source ROS brain, numerous studies have shown that knockout exerts protective effect model ischemic In this review, we summarize mechanism activation family members, pathophysiological effects isoforms stroke, inhibitors explore potential clinical applications.

Язык: Английский

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The Role of Oxidative Stress in Acute Ischemic Stroke-Related Thrombosis

Oxidative Medicine and Cellular Longevity, Год журнала: 2022, Номер 2022, С. 1 - 19

Опубликована: Ноя. 16, 2022

Acute ischemic stroke is a serious life-threatening disease that affects almost 600 million people each year throughout the world with mortality of more than 10%, while two-thirds survivors remain disabled. However, available treatments for are still limited to thrombolysis and/or mechanical thrombectomy, and there an urgent need developing new therapeutic target. Recently, intravascular oxidative stress, derived from endothelial cells, platelets, leukocytes, has been found be tightly associated stroke-related thrombosis. It not only promotes primary thrombus formation by damaging cells platelets but also maturation stability modifying fibrin components. Thus, stress expected novel target prevention treatment stroke. In this review, we first discuss mechanisms which thrombosis, then summarize biomarkers finally put forward antithrombotic therapy targeting in

Язык: Английский

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Oral health as a modifiable risk factor for cardiovascular diseases

Trends in Cardiovascular Medicine, Год журнала: 2023, Номер 34(4), С. 267 - 275

Опубликована: Март 23, 2023

Cardiovascular diseases (CVDs) are a leading cause of morbidity and mortality worldwide with high socioeconomic burden. Increasing evidence supports convincing connection increased cardiovascular risk periodontal (PD), group widespread, debilitating, costly dysbiotic relapsing-remitting inflammatory the tissues supporting teeth. Herein, we ensembled best available on between CVDs PD to review recently emerging concept latter as non-traditional factor for CVDs. We focused oral dysbiosis, inflammation-associated molecular cellular mechanisms, epigenetic changes potential causative links The effects treatment factors was also described.

Язык: Английский

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Updates on the Role of Periodontitis-Related Epigenetics, Inflammation, Oral Microbiome, and Treatment in Cardiovascular Risk

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 837 - 851

Опубликована: Фев. 1, 2024

Abstract: Substantial evidence has recently been gathered to substantiate the epidemiological correlation between this oral inflammatory ailment and several systemic health disorders, such as cardiovascular diseases (CVDs). It is worth noting that certain shared factors exist among individuals with periodontal disease (PD) CVDs, like obesity or overweight, minimal physical activities, smoking habits, male gender, low socioeconomic position, advanced age, limited educational attainment. Moreover, recent research suggests a distinct separate relationship PD CVDs. This literature review discusses association CVDs their underlying mechanisms connections. Current strongly confirms risk PD. The involve inflammation, epigenetics, epithelial dysfunction, microbiome dysbiosis, efficacy of periodontitis treatment. Future investigations are required comprehend these complex interactions develop targeted interventions for improvement reduction in risk. Keywords: disease, periodontitis, gingivitis, health, markers, inflammation

Язык: Английский

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Salivary Biomarkers of Oxidative Stress and Inflammation in Stroke Patients: From Basic Research to Clinical Practice

Oxidative Medicine and Cellular Longevity, Год журнала: 2021, Номер 2021(1)

Опубликована: Янв. 1, 2021

Cerebral stroke is a serious worldwide health problem, as can be seen by the global epidemic of disease. In this disorder, when blood flow compromised ruptures or blocked arteries, sudden death neurons observed result lack oxygen and nutrients. Numerous severe problems frequent complications also exist in patients; therefore, there an urgent need to develop new therapeutic, diagnostic, prognostic methods for At present, diagnosis based on neurological examination, medical history, neuroimaging, due fact that rapid noninvasive diagnostic tests are unavailable. Nevertheless, oxidative stress inflammation considered key factors pathogenesis. Oxygen free radicals responsible oxidation lipids, proteins, DNA/RNA, which turn contributes damage brain. Toxic products reactions act cytostatically cell damaging membranes leading neuronal apoptosis necrosis. Thus, it seems redox/inflammatory biomarkers might used Nowadays, saliva increasing interest clinical laboratory medicine. Redox could obtained easily, noninvasively, cheaply, stress‐free from saliva. This minireview aimed at presenting current knowledge concerning use salivary prognosis stroke.

Язык: Английский

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The antiglycation potential of H1 receptor antagonists – in vitro studies in bovine serum albumin model and in silico molecular docking analyses

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 175, С. 116632 - 116632

Опубликована: Апрель 24, 2024

The H1 receptor belongs to the family of rhodopsin-like G-protein-coupled receptors activated by biogenic amine histamine. antagonists are widely used in treatment allergies. However, these drugs could have a much broader spectrum activity, including hypoglycemic effects, which can broaden their use. aim study was evaluate antiglycation potential twelve (diphenhydramine, antazoline, promethazine, ketotifen, clemastine, pheniramine, cetirizine, levocetirizine, bilastine, fexofenadine, desloratadine, and loratadine). Bovine serum albumin (BSA) glycated with sugars (glucose, fructose, galactose, ribose) aldehydes (glyoxal methylglyoxal) presence blockers. tested substances did not induce significant decrease content glycation end-products, inhibition rate glycoxidation influenced chemical structure or generation None exhibited strong activity. Antiglycemic blockers be attributed antioxidant anti-inflammatory as well effects on carbohydrate metabolism/metabolic balance at systemic level.

Язык: Английский

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The Influence of Oxidative Stress Markers in Patients with Ischemic Stroke

Biomolecules, Год журнала: 2024, Номер 14(9), С. 1130 - 1130

Опубликована: Сен. 6, 2024

Stroke is the second leading cause of death worldwide, and its incidence rising rapidly. Acute ischemic stroke a subtype that accounts for majority cases has high mortality rate. An effective treatment to minimize damage brain's neural tissue by restoring blood flow decreased perfusion areas brain. Many reports have concluded both oxidative stress excitotoxicity are main pathological processes associated with stroke. Current measures protect brain against serious caused insufficient. For this reason, it important investigate antioxidant strategies reduce damage. This review focuses on studies assessing concentration biomarkers level antioxidants (enzymatic non-enzymatic) their impact clinical prognosis patients after Mechanisms related production ROS/RNS role in pathogenesis presented, as well new therapeutic aimed at reducing effects ischemia reperfusion.

Язык: Английский

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Salivary chemokines and growth factors in patients with ischemic stroke

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 12, 2025

Язык: Английский

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The Effect of Selected Dental Materials Used in Conservative Dentistry, Endodontics, Surgery, and Orthodontics as Well as during the Periodontal Treatment on the Redox Balance in the Oral Cavity

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(24), С. 9684 - 9684

Опубликована: Дек. 18, 2020

Oxidative stress (OS) is a redox homeostasis disorder that results in oxidation of cell components and thus disturbs metabolism. OS induced by numerous internal as well external factors. According to recent studies, dental treatment may also be one them. The aim our work was assess the effect on balance oral cavity. We reviewed literature available PubMed, Medline, Scopus databases, including from 2010 2020. Publications were searched according keywords: oxidative monomers; amalgam; periodontitis, braces, titanium; implants, endodontics treatment, treatment; composite. It found with use composites, amalgams, glass-ionomers, materials for root canal filling/rinsing, orthodontic braces (made various metal alloys), titanium or whitening agents can disturb affecting antioxidant barrier increasing damage salivary proteins, lipids, DNA. Abnormal saliva secretion/composition observed patients course OS. suggested addition antioxidants therapy applied during could protect patient against harmful effects

Язык: Английский

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