The Psychedelic Future of Post-Traumatic Stress Disorder Treatment

Current Neuropharmacology, Год журнала: 2024, Номер 22(4), С. 636 - 735

Опубликована: Янв. 5, 2024

Post-traumatic stress disorder (PTSD) is a mental health condition that can occur following exposure to traumatic experience. An estimated 12 million U.S. adults are presently affected by this disorder. Current treatments include psychological therapies (e.g., exposure-based interventions) and pharmacological selective serotonin reuptake inhibitors (SSRIs)). However, significant proportion of patients receiving standard-of-care for PTSD remain symptomatic, new approaches other trauma-related conditions greatly needed. Psychedelic compounds alter cognition, perception, mood currently being examined their efficacy in treating despite current status as Drug Enforcement Administration (DEA)- scheduled substances. Initial clinical trials have demonstrated the potential value psychedelicassisted therapy treat psychiatric disorders. In comprehensive review, we summarize state science care, including shortcomings. We review studies psychedelic interventions PTSD, disorders, common comorbidities. The classic psychedelics psilocybin, lysergic acid diethylamide (LSD), N,N-dimethyltryptamine (DMT) DMT-containing ayahuasca, well entactogen 3,4-methylenedioxymethamphetamine (MDMA) dissociative anesthetic ketamine, reviewed. For each drug, present history use, somatic effects, pharmacology, safety profile. rationale proposed mechanisms use traumarelated disorders discussed. This concludes with an in-depth consideration future directions applications maximize therapeutic benefit minimize risk individuals communities impacted conditions.

Язык: Английский

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Lifetime posttraumatic stress disorder as a predictor of mortality: a systematic review and meta-analysis

BMC Psychiatry, Год журнала: 2023, Номер 23(1)

Опубликована: Апрель 10, 2023

Posttraumatic Stress Disorder (PTSD) could potentially increase the risk of mortality, and there is a need for meta-analysis to quantify this association. This study aims determine extent which PTSD predictor mortality.

Язык: Английский

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Chronic Pain and Psychiatric Conditions

Complex Psychiatry, Год журнала: 2022, Номер 9(1-4), С. 24 - 43

Опубликована: Сен. 15, 2022

Chronic pain is a common condition with high socioeconomic and public health burden. A wide range of psychiatric conditions are often comorbid chronic conditions, negatively impacting successful treatment either condition. The receiving most attention in the past regard to comorbidity has been major depressive disorder, despite fact that many other also demonstrate epidemiological genetic overlap pain. Further understanding potential mechanisms involved could lead new strategies both for each type disorder isolation scenarios comorbidity.

Язык: Английский

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Dysregulation of miR-15a-5p, miR-497a-5p and miR-511-5p Is Associated with Modulation of BDNF and FKBP5 in Brain Areas of PTSD-Related Susceptible and Resilient Mice

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(10), С. 5157 - 5157

Опубликована: Май 13, 2021

Post-traumatic stress disorder (PTSD) is a neuropsychiatric occurring in susceptible individuals following traumatic event. Understanding the mechanisms subserving trauma susceptibility/resilience essential to develop new effective treatments. Increasing evidence suggests that non-coding RNAs, such as microRNAs (miRNAs), may play prominent role mediating susceptibility/resilience. In this study, we evaluated transcriptional expression of two key PTSD-related genes (FKBP5 and BDNF) relative targeting miRNAs (miR-15a-5p, miR-497a-5p, miR-511-5p, let-7d-5p) brain areas resilient mice identified through our recently developed mouse model PTSD (arousal-based individual screening (AIS) model). We observed lower transcript levels miR-15a-5p, miR-511a-5p hippocampus hypothalamus compared mice, suggesting these could discriminate different phenotypes stress-exposed mice. These miRNA variations contribute, individually or synergically, inversely correlated FKBP5 BDNF. Conversely, medial prefrontal cortex, downregulation let-7d-5p was both not accompanied by changes their mRNA targets. Furthermore, stress-induced behavioral scores (arousal score, avoidance-like social memory score PTSD-like score), linear connection between miRNA-based epigenetic modulation phenotypes. Pathway analysis network showed statistically significant enrichment molecular processes related stress. conclusion, results indicate might be shaped brain-area-dependent FKBP5, BDNF, other stress-related genes.

Язык: Английский

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Decreased PTSD Symptoms Following a Lucid Dreaming Workshop: A Randomized Controlled Study

European Journal of Trauma & Dissociation, Год журнала: 2025, Номер unknown, С. 100510 - 100510

Опубликована: Янв. 1, 2025

Язык: Английский

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NEUROBIOLOGICAL ASPECTS OF PATHOGENETIC MECHANISMS IN THE DEVELOPMENT OF POST-TRAUMATIC STRESS DISORDER (LITERATURE REVIEW)

Eastern Ukrainian Medical Journal, Год журнала: 2025, Номер 13(1), С. 39 - 54

Опубликована: Янв. 1, 2025

Post-traumatic stress disorder (PTSD) occurs as a result of exposure to life-threatening traumatic event or situation involving violence. The main manifestations PTSD are obsessive re-experiencing the event, increased nervous arousal, avoidance stimuli related emotional and cognitive disorders that persist for long time. This mental is exhausting causes changes make it difficult sometimes impossible patients with function professionally socially. results in significant clinical burden high socioeconomic costs. Materials methods. authors have reviewed more than 100 scientific papers from world literature on problems diagnosis, symptoms, pathophysiological neurobiological mechanisms play an important role development can be used key elements choice treatment measures. Results. multifactorial disease, therefore, numerous factors involved its occurrence progression. immediate response activation neuroendocrine autonomic systems release adrenaline norepinephrine. involvement hypothalamic-pituitary-adrenal system subsequent secretion cortisol may trigger development. A link has been found between activity noradrenergic system, glucocorticoid exposure, impaired interaction neurons amygdala prefrontal cortex. In addition, glucocorticoids associated immune neuroinflammation. Inflammatory cytokines regulate modify functioning neurotransmitters such serotonin dopamine, which contributes onset progression symptoms. Conclusions. data large number studies allow us confirm following pathogenesis PTSD. These include vegetative regulation, dysfunction immunological regulatory inflammatory mechanisms, dysregulation monoaminergic transmission system. Further study pathogenetic pathways will better implementation strategy medical care

Язык: Английский

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Emphasizing the Crosstalk Between Inflammatory and Neural Signaling in Post-traumatic Stress Disorder (PTSD)

Journal of Neuroimmune Pharmacology, Год журнала: 2023, Номер 18(3), С. 248 - 266

Опубликована: Апрель 25, 2023

Abstract Post-traumatic stress disorder (PTSD) is a chronic incapacitating condition with recurrent experience of trauma-related memories, negative mood, altered cognition, and hypervigilance. Agglomeration preclinical clinical evidence in recent years specified that alterations neural networks favor certain characteristics PTSD. Besides the disruption hypothalamus-pituitary-axis (HPA) axis, intensified immune status elevated pro-inflammatory cytokines arachidonic metabolites COX-2 such as PGE2 creates putative scenario worsening neurobehavioral facet This review aims to link Diagnostic Statistical Manual mental disorders (DSM-V) symptomology major mechanisms are supposed underpin transition from acute reactions development Also, demonstrate how these intertwined processes can be applied probable early intervention strategies followed by description supporting proposed mechanisms. Hence this review, several network were postulated concerning HPA COX-2, PGE2, NLRP3, sirtuins unravel possible complex neuroinflammatory obscured PTSD condition.

Язык: Английский

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Impaired learning, memory, and extinction in posttraumatic stress disorder: translational meta-analysis of clinical and preclinical studies

Translational Psychiatry, Год журнала: 2023, Номер 13(1)

Опубликована: Дек. 7, 2023

Abstract Current evidence-based treatments for post-traumatic stress disorder (PTSD) are efficacious in only part of PTSD patients. Therefore, novel neurobiologically informed approaches urgently needed. Clinical and translational neuroscience point to altered learning memory processes as key (models of) psychopathology. We extended this notion by clarifying at a meta-level (i) the role information valence, i.e. neutral versus emotional/fearful, (ii) comparability, far applicable, between clinical preclinical phenotypes. hypothesized that cross-species, emotional/fearful processing is, respectively, impaired enhanced PTSD. This preregistered meta-analysis involved literature search on PTSD+Learning/Memory+Behavior, performed PubMed. First, effect valence was estimated with random-effects meta-regression. The sources variation were explored random forest-based analysis. analyses included 92 ( N = 6732 humans) 182 6834 animals) studies. A general impairment learning, extinction observed patients, regardless valence. Impaired learning/memory fear also present animal models Yet, fear/trauma studies emotional data limited. Mnemonic phase explained most rodents but not humans. show stable cross-species These could be targeted treatments, using gained from neurobiological argue apparent discrepancies deserve further in-depth study; until then, targeting phenotype should applied utmost care.

Язык: Английский

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Comparison the Hippocampal Stathmin and TFEB Proteins Level in Animal Models of PTSD and Depression

Jentashapir Journal of Cellular and Molecular Biology, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 12, 2025

Background: Extensive evidence demonstrates that neuronal autophagic and cytoskeletal elements play critical roles in neuroplasticity. Dysregulation of neuroplasticity has been implicated the pathology depression post-traumatic stress disorder (PTSD). Transcription factor EB (TFEB) stathmin are key regulators autophagy microtubule formation, respectively. Objectives: The current study aimed to compare levels hippocampal TFEB proteins PTSD depressed animal models rats. Methods: Three groups male rat pups (n = 8) were used. first group, designated as was exposed maternal separation related stressors. second representing model, single-prolonged stress. third group served control. Anxiety-like depressive-like behaviors evaluated using elevated plus maze (EPM) forced swimming test (FST). Hippocampal protein measured western blotting. Data analyzed Prism software. One-way ANOVA post hoc Tukey tests performed evaluate statistical differences between behavioral tasks. Independent t-tests used assess groups. Results: increased both rats, while decreased. effect on expression significantly higher than PTSD. Conversely, reduction more pronounced compared Conclusions: These results suggest changes may be associated with anxiety- depression-like behaviors.

Язык: Английский

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Chlorogenic acid improves SPS-induced PTSD-like behaviors in rats by regulating the crosstalk between Nrf2 and NF-κB signaling pathway

Free Radical Biology and Medicine, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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