Development of Vitex-derived polymer nanofibers using electrochemical sensors for the treatment of polycystic ovarian syndrome in rats as an animal model

Biosensors and Bioelectronics X, Год журнала: 2024, Номер unknown, С. 100570 - 100570

Опубликована: Дек. 1, 2024

Язык: Английский

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Morpho-mechanical Analysis of PLA/Fish Gelatin Electrospun Nanofiber Scaffolds for Tissue Engineering

IFMBE proceedings, Год журнала: 2025, Номер unknown, С. 171 - 178

Опубликована: Янв. 1, 2025

Язык: Английский

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Effect of solution concentration, process parameters and a second electric field on electrospun polyamide-11 fibers

Journal of Industrial Textiles, Год журнала: 2025, Номер 55

Опубликована: Янв. 21, 2025

The electrospinning process parameters for producing polyamide 11 (PA11) nanofibers using formic acid (FA) as the solvent were investigated. Key variables such solution concentration, tip-to-collector distance, applied voltage, flow rate, and introduction of a second electric field optimized to produce uniform, bead-free nanofibers. Preliminary studies indicated that 10% (w/v) PA11/FA 25 kV voltage collector, 12 cm distance rate 0.03 mL/min yielded most consistent results in conventional nozzle setup. effects on fiber morphology examined, with increased thinner fibers due improved evaporation, while higher voltages resulted thicker fibers, highlighting complex interplay between these parameters. Flow also played significant role formation. incorporation charged metallic rings along jet path, introducing field, further uniformity. effect electrospun PA11 was observed connected increasing values, resulting an average diameter 145.7 ± 23.7 nm, minimal bead formation, uniform circular cross-section. These application show potential improving quality applications filtration, textiles, tissue engineering, contributing deeper understanding electrospinning.

Язык: Английский

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A supervised machine-learning analysis of doxorubicin-loaded electrospun nanofibers and their anticancer activity capabilities

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Март 11, 2025

Thanks to the diverse advantages of electrospun nanofibers, multiple drugs have been loaded in these nanoplatforms be delivered healthily and effectively. Doxorubicin is a drug used chemotherapy, its various delivery efficacy parameters encounter challenges, leading seeking novel methods. Researchers conducted numerous laboratory investigations on encapsulation doxorubicin within nanofiber materials. This method encompasses for production fibers loading, categorized into device-related, material-related, study design parameters. employed supervised machine-learning analysis extract influencing input from quantitative data doxorubicin-loaded nanofibers. The also determined significance coefficient each parameter that influences output results identified optimum points intervals parameter. Our Support Vector Machine (SVM) findings showed nanofibers could optimized through employing machine learning-based investigation polymer solution (such as density, solvent, electrical conductivity, concentration polymer), electrospinning voltage, flow rate, distance between needle tip collector), our parameters, i.e., release anticancer activity, which affect properties drug-loaded such average diameter fiber, percentage, efficiency. indicated importance factors like distance, concentration, respectively, optimizing fabrication smallest diameter, highest efficiency, activity are obtained at molecular weight 80 474 kDa least 3.182 wt% with density range 1.2–1.52 g/cm 3 , 6.618–9 wt%, dielectric constant solvent more than 30. Also, optimal 14–15 cm, rate 3.5–5 mL/h, voltage 20–25 kV result lowest fibers. Therefore, achieve conditions, values should considered. These open up new roads future polymeric desirable performances by learning

Язык: Английский

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Extraction and characterization of cellulose nanofibers from rice husk: potential for electrospun PVA/CNF mat composites

Kuwait Journal of Science, Год журнала: 2025, Номер unknown, С. 100403 - 100403

Опубликована: Март 1, 2025

Язык: Английский

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Efficient and high-density immobilization of animal cells by a microfiber with both swelling and cell adhesion properties and its application to exosome production

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 25, 2025

Purpose For high-density cell culture, we studied the development of optimal microfibers (MFs) with a 0.1–10 µm diameter, which due to their large surface area can serve as an immobilization carrier for animal cells. To date, few studies have used MFs scaffolding culturing. Results Using six types nonsoluble synthetic polymers, MF sheets were fabricated by electrospinning. The cellulose acetate, polyketone, and polyvinyl acetate exhibited swelling water retention capacities. Next, fragments examined immobilizing TKD2 mouse vascular endothelial Although most cells taken into three characterized swelling, leaked from without adhesion. solve this, comprising polyketones coated gelatin. adhesive capacity was enhanced, decreased almost all immobilized remained on sheets’ surfaces. Based these results, produced novel sheet gelatin, polyketone mixture (CPG). Since attached CPG fragment supplied little loss reached high density 3.2×10⁹ MF-g^{− 1}, Furthermore, continuously exosomes productivity 6–7×10¹⁰ particles ml^{− 1} after either 8h or 16h Conclusion CPG-based are expected wide range future applications, including exosome production

Язык: Английский

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Efficient and high-density immobilization of animal cells by a microfiber with both swelling and cell adhesion properties and its application to exosome production

Biotechnology Letters, Год журнала: 2025, Номер 47(2)

Опубликована: Апрель 1, 2025

Язык: Английский

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Electrospinning technology in water treatment applications: Review article

Desalination and Water Treatment, Год журнала: 2025, Номер unknown, С. 101175 - 101175

Опубликована: Апрель 1, 2025

Язык: Английский

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Fabrication and evaluation of polylactic acid-curcumin containing carbon nanotubes (CNTs) wound dressing using electrospinning method with experimental and computational approaches

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 18, 2025

The development of advanced wound dressings has seen a significant leap with the integration biodegradable nanofibers. This study introduces an innovative approach by designing polylactic acid (PLA)-curcumin nanofiber enhanced carbon nanotubes (CNTs). Using electrospinning method, various formulations were crafted, incorporating diverse weight percentages curcumin and CNTs. Comprehensive analyses, including FT-IR SEM, confirmed structural physical integrity nanofibers, while tensile testing revealed notable enhancement in mechanical strength addition Drug release evaluations highlighted controlled predictable pattern across all samples. Water absorption tests demonstrated ability PLA nanofibers to absorb up 364%, PLA-Cur-0.03%CNT samples absorbing 163%, showcasing their adaptability exudates. Importantly, cytotoxicity assessments biocompatibility samples, high cell viability observed after 3 7 days. Antibacterial underscored efficacy CNT-incorporated PLA-Cur-0.05%CNT achieving highest antibacterial activity at 78.95%. Additionally, using Density Functional Theory (DFT) calculations, transition state, HOMO-LUMO energy, equilibrium constant explored, revealing higher constants for keto-enol transformations compared enol-keto solvents. Tautomeric conversion is easier polar solvents due stability charged species. energy analysis chemical comprehensive research not only mechanical, antibacterial, drug delivery capabilities dressing but also provided optimizing pharmaceutical compounds under challenging environments through modeling computational techniques.

Язык: Английский

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Fabrication of polydopamine-altered PCL/PLGA nanofibrous scaffolds on cerium to enhance cytocompatibility, microbial inhibition, and improved osteogenic properties for tissue regeneration in orofacial treatment

Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер 766, С. 151852 - 151852

Опубликована: Апрель 18, 2025

Язык: Английский

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