Collagen-Based Wound Dressings: Innovations, Mechanisms, and Clinical Applications
Gels,
Год журнала:
2025,
Номер
11(4), С. 271 - 271
Опубликована: Апрель 5, 2025
Collagen-based
wound
dressings
have
developed
as
an
essential
component
of
contemporary
care,
utilizing
collagen’s
inherent
properties
to
promote
healing.
This
review
thoroughly
analyzes
collagen
dressing
advances,
examining
different
formulations
such
hydrogels,
films,
and
foams
that
enhance
care.
The
important
processes
by
which
promotes
healing
(e.g.,
promoting
angiogenesis,
encouraging
cell
proliferation,
offering
structural
support)
are
discussed
clarify
its
function
in
tissue
regeneration.
effectiveness
adaptability
demonstrated
via
clinical
applications
investigated
acute
chronic
wounds.
Additionally,
commercially
accessible
collagen-based
skin
treatments
discussed,
demonstrating
their
practical
use
healthcare
settings.
Despite
the
progress,
study
discusses
obstacles
restrictions
encountered
producing
adopting
dressings,
difficulties
manufacturing
financial
concerns.
Finally,
current
landscape’s
insights
indicate
future
research
possibilities
for
optimization,
bioactive
agent
integration,
overcoming
existing
constraints.
analysis
highlights
potential
innovations
improve
treatment
methods
patient
Язык: Английский
Dipalmitoylphosphatidylcholine Lipid Vesicles for Delivering HMB, NMN, and L-Leucine in Sarcopenia Therapy
Molecules,
Год журнала:
2025,
Номер
30(7), С. 1437 - 1437
Опубликована: Март 24, 2025
Sarcopenia,
characterized
by
the
degeneration
of
skeletal
muscle
tissue,
has
emerged
as
a
significant
concern
in
recent
years.
This
increased
awareness
stems
from
advances
research
focusing
on
elderly
patients,
which
have
revealed
correlations
between
aging
mechanisms
and
degeneration,
beyond
mere
fact
that
tissues
age
deteriorate
over
time.
Consequently,
present
study
aims
to
address
sarcopenia
developing
evaluating
DPPC
lipid
vesicles
encapsulate
three
distinct
drugs:
HMB,
NMN,
L-Leucine.
These
drugs
are
specifically
selected
for
their
properties,
facilitate
effective
interaction
with
affected
thereby
promoting
desired
therapeutic
effects.
Preliminary
physicochemical
analyses
indicate
successful
formation
spherical
vesicles,
nanometric
dimensions
stable
membrane
integrity.
The
biological
investigations
aimed
highlight
potential
encapsulating
L-Leucine
alleviate
sarcopenia-induced
cytotoxicity
oxidative
stress.
Through
comparative
evaluation
drug
formulations,
we
demonstrate
drug-loaded
effectively
mitigate
damage,
preserve
mitochondrial
function,
maintain
cytoskeletal
integrity
H2O2-induced
C2C12
myotubes,
HMB-loaded
showing
strongest
protective
effects
against
degeneration.
findings
underscore
DPPC-based
controlled
release
systems
treatment
need
further
into
mechanistic
role
preservation.
Язык: Английский
Antibacterial Properties of Polymeric Membranes Containing Doxycycline for Potential Applications in Foot Ulcer Treatment
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 3274 - 3274
Опубликована: Апрель 1, 2025
Membranes
made
from
biopolymers
and
loaded
with
doxycycline
were
investigated
for
potential
use
in
the
treatment
of
foot
ulcers
diabetic
patients.
Carboxymethylcellulose
(CMC)
chitosan
(CHS)
membranes
fabricated
7%
glycerol
1%
(DOX).
Their
mechanical
physical
properties,
biocompatibility,
antimicrobial
effects
thoroughly
evaluated.
The
results
demonstrated
effective
antibacterial
activity
against
S.
aureus
mutans.
Based
on
mechanical,
physical,
hemolytic
data,
DOX-loaded
CMC/CHS/G
show
promise
as
a
topical
wound
delivery
system.
Язык: Английский
Advances in biomaterials for wound care management: Insights from recent developments
Advances in Colloid and Interface Science,
Год журнала:
2025,
Номер
unknown, С. 103563 - 103563
Опубликована: Май 1, 2025
Язык: Английский
Zinc Alginate Hydrogel-Coated Wound Dressings: Fabrication, Characterization, and Evaluation of Anti-Infective and In Vivo Performance
Gels,
Год журнала:
2025,
Номер
11(6), С. 427 - 427
Опубликована: Июнь 1, 2025
The
delayed
healing
and
infection
risks
associated
with
chronic
wounds
burns
pose
significant
clinical
challenges.
Traditional
dressings
provide
basic
coverage
but
lack
the
bioactive
properties
needed
for
tissue
regeneration
antimicrobial
protection.
In
this
study,
we
developed
zinc
alginate
hydrogel-coated
traditional
wound
(WD@AlgZn)
evaluated
their
physicochemical
properties,
performance,
in
vivo
efficacy.
Scanning
electron
microscopy
(SEM)
revealed
a
uniform
coating
of
network
on
dressing
fibers,
while
Fourier-transform
infrared
spectroscopy
(FT-IR)
confirmed
successful
incorporation
ions.
Antimicrobial
assays
further
demonstrated
that
WD@AlgZn
reduced
bacterial
loads
(CFU/mL
counts)
by
several
orders
magnitude
both
Staphylococcus
aureus
Escherichia
coli
compared
to
uncoated
controls.
An
rat
burn
model
exhibited
accelerated
closure
when
using
conventional
care
approaches,
achieving
90.75%
rate
day
21,
significantly
outperforming
silver
sulfadiazine
(52.32%),
uncoated-dressing
(46.58%),
spontaneous-healing
(37.25%)
groups.
Histological
analysis
enhanced
re-epithelialization,
neovascularization,
inflammation
WD@AlgZn-treated
tissues.
findings
suggest
offers
promising
alternative
advanced
management,
combining
structural
robustness
support
efficient
control.
These
results
valuable
insights
into
potential
applications
metal-ion
cross-linked
biopolymeric
hydrogel
next-generation
strategies.
Язык: Английский
A cellulose-based skin adhesive hydrogel incorporating N-acetyl-seryl-aspartyl-lysyl-proline peptide for enhanced wound healing and scar prevention in rabbit scar ear model in vivo
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 144981 - 144981
Опубликована: Июнь 1, 2025
Язык: Английский