Polydopamine Nanocomposite Hydrogel for Drug Slow-Release in Bone Defect Repair: A Review of Research Advances

Gels, Год журнала: 2025, Номер 11(3), С. 190 - 190

Опубликована: Март 8, 2025

In recent years, hydrogels have emerged as promising candidates for bone defect repair due to their excellent biocompatibility, high porosity, and water-retentive properties. However, conventional face significant challenges in clinical translation, including brittleness, low mechanical strength, poorly controlled drug degradation rates. To address these limitations, a multifunctional polymer, polydopamine (PDA) has shown great potential both regeneration delivery systems. Its robust adhesive properties, responsiveness photothermal stimulation make it an ideal candidate enhancing hydrogel performance. Integrating PDA into not only improves properties but also creates environment conducive cell adhesion, proliferation, differentiation, thereby promoting repair. Moreover, facilitates release, offering approach optimizing treatment outcomes. This paper first explores the mechanisms through which promotes regeneration, laying foundation its translation. Additionally, discusses application of PDA-based nanocomposite advanced systems repair, providing valuable insights research

Язык: Английский

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Hydrogel Composite Incorporating Deferoxamine-Loaded Gelatin-Based Microspheres Enhance Angiogenesis Ability of Dental Pulp Stem Cells

ACS Omega, Год журнала: 2025, Номер unknown

Опубликована: Март 21, 2025

Fast reconstruction of the pulpal vasculature is crucial for effective pulp regeneration. Dental stem cells (DPSCs) are promising candidates regeneration because their potential multilineage differentiation and vasculogenic properties. Deferoxamine (DFO) has been shown to stimulate angiogenesis during wound healing bone regeneration; however, effects DFO on angiogenic DPSCs remain unknown. Moreover, its usefulness restricted by a limited half-life challenges in achieving localized tissue enrichment. This study aimed develop sustained-release injectable hydrogel composite as drug delivery system investigate influence DPSCs. Herein, gelatin-based microspheres (GMSs) were loaded with DFO, temperature-sensitive hydrogels incorporating collagen chitosan synthesized enable controlled release. The experimental findings demonstrated that DFO-loaded GMSs (DFO-GMSs) possessed favorable physical properties biocompatibility, enabling sustained up 15 days. effectively stimulated DPSC migration, promoted secretion angiogenesis-related factors, induced tube formation vitro. These results suggest DFO-GMSs significantly increased migration DPSCs, highlighting promise applications.

Язык: Английский

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Recent Strategies and Advances in Hydrogel-Based Delivery Platforms for Bone Regeneration

Nano-Micro Letters, Год журнала: 2024, Номер 17(1)

Опубликована: Ноя. 27, 2024

Abstract Bioactive molecules have shown great promise for effectively regulating various bone formation processes, rendering them attractive therapeutics regeneration. However, the widespread application of bioactive is limited by their low accumulation and short half-lives in vivo. Hydrogels emerged as ideal carriers to address these challenges, offering potential prolong retention times at lesion sites, extend vivo mitigate side effects, avoid burst release, promote adsorption under physiological conditions. This review systematically summarizes recent advances development molecule-loaded hydrogels regeneration, encompassing applications cranial defect repair, femoral periodontal regeneration with underlying diseases. Additionally, this discusses current strategies aimed improving release profiles through stimuli-responsive delivery, carrier-assisted sequential delivery. Finally, elucidates existing challenges future directions hydrogel encapsulated field

Язык: Английский

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Review: osseointegration of titanium-based and zirconia implants: novel perspective on features, influencing factors and improvements

Journal of Materials Science, Год журнала: 2024, Номер 59(34), С. 16020 - 16037

Опубликована: Авг. 26, 2024

Язык: Английский

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