Kombucha Versus Vegetal Cellulose for Affordable Mucoadhesive (nano)Formulations DOI Creative Commons
Ioana Popa‐Tudor, Naomi Tritean, Ştefan‐Ovidiu Dima

и другие.

Gels, Год журнала: 2025, Номер 11(1), С. 37 - 37

Опубликована: Янв. 4, 2025

Cellulose nanofibers gained increasing interest in the production of medical devices such as mucoadhesive nanohydrogels due to their ability retain moisture (high hydrophilicity), flexibility, superior porosity and durability, biodegradability, non-toxicity, biocompatibility. In this work, we aimed compare suitability selected bacterial vegetal nanocellulose form hydrogels for biomedical applications. The cellulose were synthesized from brewer's spent grains (BSG) kombucha membranes, respectively. Two prepared, one based on other (VNC BNC, respectively). VNC was less opaque more fluid than BNC. cytocompatibility vitro antioxidant activity nanocellulose-based investigated using human gingival fibroblasts (HGF-1, ATCC CRL-2014). investigation hydrogel-mucin interaction revealed that BNC hydrogel had an approx. 2× higher mucin binding efficiency at a hydrogel/mucin ratio (mg/mg) = 4. exhibited highest potential increase number metabolically active viable cells (107.60 ± 0.98% cytotoxicity negative control) among all culture conditions. reduced amount reactive oxygen species (ROS) by about 23% (105.5 2.2% C-) comparison with positive control, whereas ROS level slightly (120.2 3.9% following treatment. Neither two showed antibacterial when assessed diffusion method. data suggest fermentation could be better candidate cytocompatible nanoformulations grains. both VNC, respectively, should improved.

Язык: Английский

Kombucha Versus Vegetal Cellulose for Affordable Mucoadhesive (nano)Formulations DOI Creative Commons
Ioana Popa‐Tudor, Naomi Tritean, Ştefan‐Ovidiu Dima

и другие.

Gels, Год журнала: 2025, Номер 11(1), С. 37 - 37

Опубликована: Янв. 4, 2025

Cellulose nanofibers gained increasing interest in the production of medical devices such as mucoadhesive nanohydrogels due to their ability retain moisture (high hydrophilicity), flexibility, superior porosity and durability, biodegradability, non-toxicity, biocompatibility. In this work, we aimed compare suitability selected bacterial vegetal nanocellulose form hydrogels for biomedical applications. The cellulose were synthesized from brewer's spent grains (BSG) kombucha membranes, respectively. Two prepared, one based on other (VNC BNC, respectively). VNC was less opaque more fluid than BNC. cytocompatibility vitro antioxidant activity nanocellulose-based investigated using human gingival fibroblasts (HGF-1, ATCC CRL-2014). investigation hydrogel-mucin interaction revealed that BNC hydrogel had an approx. 2× higher mucin binding efficiency at a hydrogel/mucin ratio (mg/mg) = 4. exhibited highest potential increase number metabolically active viable cells (107.60 ± 0.98% cytotoxicity negative control) among all culture conditions. reduced amount reactive oxygen species (ROS) by about 23% (105.5 2.2% C-) comparison with positive control, whereas ROS level slightly (120.2 3.9% following treatment. Neither two showed antibacterial when assessed diffusion method. data suggest fermentation could be better candidate cytocompatible nanoformulations grains. both VNC, respectively, should improved.

Язык: Английский

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