Journal of Angiotherapy,
Год журнала:
2023,
Номер
7(2)
Опубликована: Дек. 23, 2023
Addressing
the
high
mortality
rate
and
limited
treatment
options
for
oral
cancer
is
a
global
public
health
challenge.
To
enhance
therapeutic
approaches,
comprehensive
understanding
of
stem
cells
(OCSCs)
essential.
This
review
employs
advanced
bio-inspired
methods
to
identify
unique
pharmacological
targets
within
OCSCs,
considering
their
heterogeneity
resistance
conventional
treatments.
The
Evolutionary
Computation
Network
Drug
Repositioning
(ECN-DR)
dissects
intricate
signaling
pathways
molecular
networks
OCSCs
using
techniques.
By
integrating
machine
learning,
network
analysis,
dynamics
simulations,
this
approach
identifies
potential
both
new
existing
anticancer
drugs.
Recognizing
key
players
in
enables
design
tailored
medicines
disrupt
these
cells,
offering
more
potent
targeted
therapy
with
fewer
side
effects.
Molecular
protein-ligand
docking
studies,
silico
drug
screening
predict
binding
affinity
prospective
medications
against
selected
OCSC
targets.
These
simulations
contribute
better
targeting
specific
proteins
therapy.
Utilizing
computational
enhances
our
knowledge
biology,
advancing
prospects
personalized
treatment.
Life Sciences,
Год журнала:
2024,
Номер
352, С. 122899 - 122899
Опубликована: Июль 9, 2024
This
comprehensive
review
provides
an
in-depth
analysis
of
how
nanotechnology
has
revolutionized
cancer
theragnostic,
which
combines
diagnostic
and
therapeutic
methods
to
customize
treatment.
The
study
examines
the
unique
attributes,
uses,
difficulties
linked
different
types
nanoparticles,
including
gold,
iron
oxide,
silica,
Quantum
dots,
Carbon
nanotubes,
liposomes,
in
context
In
addition,
paper
progression
nanotheranostics,
emphasizing
its
uses
precise
medication
administration,
photothermal
therapy,
sophisticated
such
as
MRI,
CT,
fluorescence
imaging.
Moreover,
article
highlights
capacity
nanoparticles
improve
effectiveness
drugs,
reduce
overall
toxicity
body,
open
up
new
possibilities
for
treating
by
releasing
drugs
a
controlled
manner
targeting
specific
areas.
Furthermore,
it
tackles
concerns
regarding
compatibility
their
potential
harmful
effects,
significance
continuous
nanotherapeutic
use
medical
treatments.
finishes
outlining
future
applications
predictive
oncology
customized
medicine.
Abstract
This
review
explores
recent
advancements
and
applications
of
3D
printing
in
healthcare,
with
a
focus
on
personalized
medicine,
tissue
engineering,
medical
device
production.
It
also
assesses
economic,
environmental,
ethical
considerations.
In
our
the
literature,
we
employed
comprehensive
search
strategy,
utilizing
well-known
databases
like
PubMed
Google
Scholar.
Our
chosen
keywords
encompassed
essential
topics,
including
printing,
nanotechnology,
related
areas.
We
first
screened
article
titles
abstracts
then
conducted
detailed
examination
selected
articles
without
imposing
any
date
limitations.
The
for
inclusion,
comprising
research
studies,
clinical
investigations,
expert
opinions,
underwent
meticulous
quality
assessment.
methodology
ensured
incorporation
high-quality
sources,
contributing
to
robust
exploration
role
realm
healthcare.
highlights
printing's
potential
customized
drug
delivery
systems,
patient-specific
implants,
prosthetics,
biofabrication
organs.
These
innovations
have
significantly
improved
patient
outcomes.
Integration
nanotechnology
has
enhanced
precision
biocompatibility.
demonstrates
cost-effectiveness
sustainability
through
optimized
material
usage
recycling.
healthcare
sector
witnessed
remarkable
progress
promoting
patient-centric
approach.
From
implants
radiation
shielding
offers
tailored
solutions.
Its
transformative
applications,
coupled
economic
viability
sustainability,
revolutionize
Addressing
biocompatibility,
standardization,
concerns
is
responsible
adoption.
Graphical
Some
of
the
most
crucial
turning
points
in
treatment
strategies
for
some
major
infectious
diseases
including
AIDS,
malaria,
and
TB,
have
been
reached
with
introduction
antimicrobials
vaccines.
Drug
resistance
poor
effectiveness
are
key
limitations
that
need
to
be
overcome.
Conventional
liposomes
explored
as
a
delivery
system
bioactives
treat
provide
an
efficient
approach
maximize
therapeutic
outcomes,
drug
stability,
targetability,
reduce
side-effects
antimicrobials,
enhance
vaccine
performance
where
necessary.
However,
pathological
understanding
become
more
known,
advanced
liposomal
technologies
was
born
continue
having
profound
effect
on
targeted
chemotherapy
diseases.
This
review
therefore
provides
concise
incursion
into
recent
vogue
formulations
used
An
appraisal
immunological,
stimuli-responsive,
biomimetic
functionalized
other
novel
modifications
conventional
is
assimilated
sync
mutations
resistant
pathogens.
Frontiers in Nanotechnology,
Год журнала:
2025,
Номер
6
Опубликована: Янв. 22, 2025
Extracellular
vesicles
(EVs),
natural
membrane-bound
structures
released
by
cells,
offer
a
promising
platform
for
precise
and
targeted
delivery
of
therapeutic
payloads,
including
drugs
nanoparticles.
This
comprehensive
review
explores
the
integration
engineered
nanomaterials
with
EVs
to
advance
drug
systems.
It
covers
various
aspects
this
integration,
techniques
synthesizing,
loading,
characterizing,
applying
within
EVs.
Methodologies
integrating
diverse
nanocarriers
like
nanoparticles,
liposomes,
quantum
dots
into
are
discussed,
along
characterization
methods
such
as
electron
microscopy
light
scattering.
Attention
is
also
given
considerations
biological
compatibility,
safety
assessments,
strategies
surface
modification
enhance
targeting
precision.
Highlighting
applications,
delivery,
cancer
therapy,
vaccine
development,
underscores
potential
EV-nanomaterial
hybrids
leverage
EVs’
innate
capabilities
versatility
nanomaterials.
However,
it
addresses
challenges
scalability,
standardization,
that
must
be
overcome
facilitate
clinical
translation
these
biomedical
solutions.
Viruses,
Год журнала:
2025,
Номер
17(2), С. 218 - 218
Опубликована: Фев. 1, 2025
Cancer
is
a
major
global
health
problem
that
poses
significant
challenges.
Conventional
cancer
therapies
often
have
severe
side
effects,
necessitating
the
development
of
novel
therapeutic
approaches
are
more
effective
and
less
toxic.
The
utilization
plant
viral
nanoparticles
one
promising
strategies
for
biotherapy.
Plant
exhibit
advantageous
properties,
including
safety,
high
stability,
rapid
production
scalability,
biocompatibility
biodegradability,
structural
uniformity,
inherent
immunogenicity,
ease
modification
update
efficacy
as
well
lower
cost
implications,
making
them
attractive
vehicles
applications.
Various
studies
demonstrated
in
targeted
drug/molecule
delivery,
tumor
imaging
immunotherapy,
highlighting
their
potential
versatile
platform
drawbacks
include
perceived
ability
to
induce
hypersensitive/allergic
immune
response,
non-well-defined
regulatory
approval
processes
reluctance
pharmaceutical
companies
adapt
manufacturing
facilitate
plant-based
expression.
This
review
discusses
applications
virus-derived
therapeutics
prospects
translating
these
findings
into
clinical
practice.
Pathology - Research and Practice,
Год журнала:
2024,
Номер
260, С. 155402 - 155402
Опубликована: Июнь 14, 2024
Colorectal
cancer
(CRC)
stands
second
in
terms
of
mortality
and
third
among
the
highest
prevalent
kinds
globally.
CRC
prevalence
is
rising
moderately
poorly
developed
regions
greater
economically
advanced
regions.
Despite
breakthroughs
targeted
therapy,
resistance
to
chemotherapeutics
remains
a
significant
challenge
long-term
management
CRC.
Circular
RNAs
(circRNAs)
have
been
involved
growing
therapy
resistance,
particularly
CRC,
according
an
increasing
number
studies
recent
years.
CircRNAs
are
one
novel
subclasses
non-coding
RNAs,
previously
thought
as
viroid.
According
studies,
circRNAs
recommended
biological
markers
for
therapeutic
targets
diagnostic
prognostic
purposes.
That
notable
given
that
expression
has
linked
hallmarks
since
they
responsible
drug
patients;
thereby,
chemotherapy
failure.
Moreover,
knowledge
concerning
relatively
unclear
despite
using
all
these
techniques.
Here,
this
study,
we
will
go
over
most
published
work
highlight
critical
roles
development
main
strategies
overcome
improve
clinical
outcomes.
Plants,
Год журнала:
2024,
Номер
13(20), С. 2836 - 2836
Опубликована: Окт. 10, 2024
Worldwide,
cancer
ranks
among
the
foremost
contributors
to
mortality
despite
recent
medical
progress.
Alternative
approaches
in
controlling
various
forms
of
are
being
highly
explored
by
researchers.
This
study
provides
global
research
trends
utilization
medicinal
plant-synthesized
nanoparticles
for
treatment
over
span
18
years
using
scientometric
analysis.
Recent
advances
on
plant-derived
and
their
possible
mechanisms
action
were
described.
Relevant
articles
published
between
2005
2023
retrieved
from
Scopus
Web
Science
analyzed
RStudio
VOSViewer.
Scientometric
indicators
employed
analyze
results.
The
initial
search
returned
5695
articles,
with
a
publication
growth
rate
3.71%
annually.
Countries
Asia
contributed
most
(61.37%)
total
number
publications.
therapeutic
effects
derived
plants
can
be
attributed
mechanistic
pathways,
including
induced
apoptosis
reactive
oxygen
species
generation,
as
well
mitochondrial
cell
membrane
disruption,
amongst
others.
Although
some
reported
studies
demonstrated
promising
safety
efficacy
against
certain
cells
vivo
vitro,
little
no
clinical
data
hinder
ability
make
informed
decisions
about
potential
treatment.
