Frontiers in Medicine, Год журнала: 2024, Номер 11
Опубликована: Ноя. 29, 2024
Colonization of the human gut and tumor tissue by non-pathogenic fungi has emerged as a potential risk factor associated with cancer epidemics. Therefore, we aimed to conduct systematic review assess role fungal colonization in gastrointestinal (GI) tumors increasing diagnostic efficiency.
Язык: Английский
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Сен. 26, 2024
The human gastrointestinal (GI) tract microbiome is a complex and all-encompassing ecological system of trillions microorganisms. It plays vital role in digestion, disease prevention, overall health. When this delicate balance disrupted, it can lead to various health issues. Fecal microbiota transplantation (FMT) an emerging therapeutic intervention used as adjuvant therapy for many diseases, particularly those with dysbiosis their underlying cause. Its goal restore by transferring fecal material from healthy donors the recipients. FMT has impressive reported cure rate between 80% 90% become favored treatment diseases. While may have generally mild moderate transient adverse effects, rare severe complications underscore importance rigorous donor screening standardized administration. enormous potential practical approach; however, additional research required further determine its clinical utilization, well safety efficiency different patient populations. This comprehensive literature review offers increased confidence effectiveness several diseases affecting intestines other systems, including diabetes, obesity, inflammatory autoimmune illness, conditions.
Язык: Английский
Процитировано
11
iMeta, Год журнала: 2025, Номер 4(1)
Опубликована: Фев. 1, 2025
Abstract Recent advances in understanding the modulatory functions of gut and microbiota on human diseases facilitated our focused attention contribution to pathophysiological alterations many extraintestinal organs, including liver, heart, brain, lungs, kidneys, bone, skin, reproductive, endocrine systems. In this review, we applied “gut–X axis” concept describe linkages between other organs discussed latest findings related axis,” underlying mechanisms potential clinical intervention strategies.
Язык: Английский
Процитировано
1
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 31, 2025
Asthma poses significant societal costs, and a wholesome diet coupled with an energetic lifestyle might enhance postpartum results. Regrettably, empirical investigations into dietary aspects that amplify asthma risk remain scarce. The oxidative balance scores (OBS), quantifying stress from elements parameters, lack definitive link to overall cardiovascular mortality among asthmatic individuals. Data sourced NHANES (1999-2020) were utilized investigate the correlation between OBS index all-cause patients. Rigor was maintained through implementation of subgroup sensitivity analyses authenticate findings. study finally included 4,639 individuals mean age 42.55 years 43.46% males. Kaplan-Meier curves showed asthmatics lower quartiles had higher mortality. In fully adjusted Model 2, HR for in upper quartile 0.37 (95% CI: 0.26, 0.53), contrast asthmatics. Cardiovascular disease consistency (Q4, HR: 0.43, 95% 0.19, 0.98). association both patients remained stable across different models assessments. Restricted cubic spline linearly associated A analysis reinforced negative negatively correlated asthma, emphasizing protective effect antioxidant healthy asthma.
Язык: Английский
Процитировано
0
Journal of Asthma and Allergy, Год журнала: 2025, Номер Volume 18, С. 349 - 361
Опубликована: Март 1, 2025
Asthma is a common chronic respiratory disease that affects children and adults can have serious impact on their quality of life. Factors contributing to the development asthma related exacerbations are multifactorial, with microbial communities colonizing airways possibly playing key role. The study included asthmatic (79) healthy (57) aged 5-16 years. Nasal throat swabs were collected, bacterial (16s rRNA) fungal (18s amplicon sequence analysis was performed. Diversity indices most abundant genera estimated accordingly. At level bacteriome in nasal samples, group had significantly lower diversity than control (p = 0.02). However, microbiota cohort more evenly distributed, staphylococci enriched group. Throat samples collected from revealed < 0.0001), significant difference species composition between two groups 0.005). Enriched different within subgroups (controlled vs uncontrolled asthma). microbiome showed no richness groups, however, beta (species composition) detected. Malassezia species, while cases Mucor species. On other hand, specimens found be Candida Saccharomyces. Our findings suggest less diverse certain enriching some groups. Addressing biomarkers influence progression could lead improved care for suffering severe episodes, by including targeted therapies prevention strategies.
Язык: Английский
Процитировано
0
Cell Biology and Toxicology, Год журнала: 2024, Номер 40(1)
Опубликована: Окт. 9, 2024
Mitochondria are essential organelles within cells, playing various roles in numerous cellular processes, including differentiation, growth, apoptosis, energy conversion, metabolism, and immunity. The phenotypic variation of mitochondria is specific to different tissues cell types, resulting significant differences their function, morphology, molecular characteristics. Asthma a chronic, complex, heterogeneous airway disease influenced by external factors such as environmental pollutants allergen exposure, well internal at the tissue, cellular, genetic levels, lung structural immune granulocytes, mast cells. Therefore, comprehensive understanding responses stimuli changes crucial for elucidating pathogenesis asthma. Previous research on mitochondrial-targeted therapy asthma has primarily focused antioxidants. Consequently, it necessary summarize multifaceted discover additional strategies targeting this context. In review, our goal describe mitochondrial function response exposure across types other relevant context asthma, utilizing new terminology framework that encompasses cell-dependent characteristics, features, activity, behavior.
Язык: Английский
Процитировано
0
Frontiers in Medicine, Год журнала: 2024, Номер 11
Опубликована: Ноя. 29, 2024
Colonization of the human gut and tumor tissue by non-pathogenic fungi has emerged as a potential risk factor associated with cancer epidemics. Therefore, we aimed to conduct systematic review assess role fungal colonization in gastrointestinal (GI) tumors increasing diagnostic efficiency.
Язык: Английский
Процитировано
0