Fungal Pericarditis—A Systematic Review of 101 Cases

Microorganisms, Год журнала: 2025, Номер 13(4), С. 707 - 707

Опубликована: Март 21, 2025

Background: Fungal pericarditis is a rare disease but its incidence has risen in parallel with the global increase invasive fungal infections. This systematic review analyzes data from previously reported cases of to provide an improved understanding etiology, clinical presentation, management, and outcomes this disease. Methodology: We reviewed Medline Scopus databases 1 January 1990 29 2024 for case reports that documented isolation pathogen pericardial fluid or tissue. Results: Of 2330 articles screened, 101 met inclusion criteria. Patients involvement at least one other organ—usually lungs, brain, kidney—had worse than patients isolated Immunosuppression was 50% associated adults. who presented chest pain, received adequate empiric antifungal therapy, underwent pericardiocentesis pericardiectomy had survival. The most common pathogens were Candida spp., followed by Aspergillus spp. Mucor latter two linked outcomes. Only 35% medications before causative identified, mortality delay appropriate therapy. Immunosuppression, disseminated disease, presence shock/multiorgan failure additional risk factors death. Conclusions: carries rate up 50%, nearly half being immunocompromised. Clinicians frequently do not consider differential diagnoses, which leads delays treatment poorer Further prospective multicenter studies are urgently needed better understand epidemiology, improve diagnostic testing decrease unacceptably high pericarditis.

Язык: Английский

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Impact of Candida auris on Critically Ill Patients: A Three-Year Observational Study in a Greek Intensive Care Unit

Pathogens, Год журнала: 2025, Номер 14(4), С. 328 - 328

Опубликована: Март 28, 2025

Candida auris has emerged as a multidrug-resistant yeast implicated in healthcare-associated invasive infections and hospital outbreaks. The aim of the current 38-month period observational study multidisciplinary Intensive Care Unit (ICU) was to analyze epidemiology, potential risk factors, management strategies, patient outcomes patients with C. auris. During period, 32 were identified infection (6 patients) or colonization (26 their clinical characteristics treatment-related factors compared. Identification isolates confirmed by MALDI-TOF spectrometry. According our results, regarding patient-related no significant differences identified. Regarding proportion already receiving corticosteroids (34.6% vs. 83.3%, p = 0.064) being on renal replacement treatment (7.7% 33.3%) higher infected patients. Median time elapsed from ICU admission first positive culture 7 (1-21) days half cases ICU-imported. All strains resistant fluconazole susceptible echinocandines amphotericin B. Crude mortality population 43.75%, similar other previously reported candidemias. Rapid identification auris, continued surveillance, control practices are important elements for controlling successfully its spread setting establishing promptly transition commensalism infection.

Язык: Английский

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Clinical isolation, biofilm formation, and pathogenicity analysis of different species of the Stephanoascus ciferrii complex

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Апрель 9, 2025

The Stephanoascus ciferrii complex, comprising ciferrii, Candida allociferrii, and mucifera, is an emerging fungal pathogen with increasing isolation rates antifungal resistance. However, detailed information about clinical pathogenicity comparisons among the three species are lacking. In order to fill in this gap, study aimed investigate compare of species. Twenty-seven S. complex strains isolated from secretion specimens patients admitted Nanjing Drum Tower Hospital between 2012 2023 were included. According results ITS sequencing, there 15 7 C. 5 mucifera. Antifungal susceptibility testing demonstrated that exhibited high MICs against azole agents, particularly fluconazole, while it showed lower echinocandins. displayed higher caspofungin than allociferrii (P < 0.05). biofilm quantification using crystal violet staining indicated stronger biofilm-forming ability RPMI-1640 medium 0.05), but was no significant difference mucifera or similar metabolic activity by XTT assay. G. mellonella larvae infection experiments revealed survival infected 60%, 50%, 48% at 24 h, 48 72 respectively. Furthermore, lethality caused significantly 0.001). This first describe formation context. Our research reveals prevalence elucidates correlation drug resistance, formation, virulence, thus providing essential empirical evidence for further pathogenic characteristics each treatment strategies.

Язык: Английский

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Neonatal Fungemia by Non-Candida Rare Opportunistic Yeasts: A Systematic Review of Literature

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9266 - 9266

Опубликована: Авг. 27, 2024

Fungal colonization poses a significant risk for neonates, leading to invasive infections such as fungemia. While Candida species are the most commonly identified pathogens, other rare yeasts increasingly reported, complicating diagnosis and treatment due limited data on antifungal pharmacokinetics. These emerging yeasts, often opportunistic, underscore critical need early targeted therapy in neonates. This systematic review aims comprehensively analyze all published cases of neonatal fungemia caused by opportunistic examining geographical distribution, involved, factors, approaches, outcomes. Searching two databases (PubMed SCOPUS), 89 relevant studies with total 342 were 42-year period; 62% occurred Asia. Pichia anomala (31%), Kodamaea ohmeri (16%) Malassezia furfur (15%) dominated. Low birth weight, use central catheters, prematurity, antibiotics main factors (98%, 76%, 66%, 65%, respectively). 22% had fatal outcome (80% Asia). The highest mortality rates reported Trichosporon beigelii asahii cases, followed Dirkmeia churashimamensis (80%, 71%, 42% antibiotics, prematurity (84%, 74%, 70%, 67%, 38% neonates received fluconazole but 46% them, died. Moreover, this showed high MICs should be taken into account when planning prophylactic or therapeutic strategies drug. In conclusion, is life-threatening difficult-to-treat infection, underestimated misdiagnosed.

Язык: Английский

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Assessment of LAMPAuris for Rapid Detection of Candida auris in Clinical Specimens

Mycopathologia, Год журнала: 2024, Номер 189(5)

Опубликована: Сен. 23, 2024

Язык: Английский

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Zingerone effect against Candida albicans growth and biofilm production.

Journal de Mycologie Médicale, Год журнала: 2024, Номер 35(1), С. 101527 - 101527

Опубликована: Дек. 13, 2024

Язык: Английский

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