Nitric Oxide-Mediated Regulation of Chitinase Activity and Cadmium Sequestration in the Response of Schizophyllum commune to Cadmium Stress DOI Creative Commons
Dongxu Li, Chen Chu,

Mengshi Zhao

и другие.

Microorganisms, Год журнала: 2025, Номер 13(3), С. 470 - 470

Опубликована: Фев. 20, 2025

Schizophyllum commune is an edible fungus with high medicinal value, but exposure to heavy-metal pollution poses significant health risks. Cadmium (Cd) toxicity inhibits fungal growth and leads Cd accumulation in the mycelium. However, regulatory mechanisms of Cd-induced inhibition remain poorly understood. Here, S. 20R-7-F01 was cultured Cd-supplemented minimal medium (MM) investigate response exposure. We found that resulted a Cd-dependent increase endogenous nitric oxide (NO) levels. NO production primarily mediated by nitrate reductase (NR) pathway. alleviated inhibiting NR activity or scavenging NO, highlighting role stress responses. Furthermore, enhance chitinase activity, thereby promoting cell wall leading inhibition. These results reveal novel mechanism which copes stress. This study highlights potential manipulating levels as strategy tolerance pollution, providing new avenue for managing environmental stresses fungi protecting human health.

Язык: Английский

Nitric Oxide-Mediated Regulation of Chitinase Activity and Cadmium Sequestration in the Response of Schizophyllum commune to Cadmium Stress DOI Creative Commons
Dongxu Li, Chen Chu,

Mengshi Zhao

и другие.

Microorganisms, Год журнала: 2025, Номер 13(3), С. 470 - 470

Опубликована: Фев. 20, 2025

Schizophyllum commune is an edible fungus with high medicinal value, but exposure to heavy-metal pollution poses significant health risks. Cadmium (Cd) toxicity inhibits fungal growth and leads Cd accumulation in the mycelium. However, regulatory mechanisms of Cd-induced inhibition remain poorly understood. Here, S. 20R-7-F01 was cultured Cd-supplemented minimal medium (MM) investigate response exposure. We found that resulted a Cd-dependent increase endogenous nitric oxide (NO) levels. NO production primarily mediated by nitrate reductase (NR) pathway. alleviated inhibiting NR activity or scavenging NO, highlighting role stress responses. Furthermore, enhance chitinase activity, thereby promoting cell wall leading inhibition. These results reveal novel mechanism which copes stress. This study highlights potential manipulating levels as strategy tolerance pollution, providing new avenue for managing environmental stresses fungi protecting human health.

Язык: Английский

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