Journal of Molecular Structure, Год журнала: 2023, Номер 1291, С. 135852 - 135852
Опубликована: Июнь 1, 2023
Язык: Английский
Microbial Cell Factories, Год журнала: 2023, Номер 22(1)
Опубликована: Июнь 6, 2023
Abstract Human life has been significantly impacted by the creation and spread of novel species antibiotic-resistant bacteria virus strains that are difficult to manage. Scientists researchers have recently motivated seek out alternatives other sources safe ecologically friendly active chemicals a powerful effective effect against wide variety pathogenic as result all these hazards problems. In this review, endophytic fungi their bioactive compounds biomedical applications were discussed. Endophytes, new category microbial source can produce biological components, major values for study broad prospects development. Recently, received much attention compounds. addition, natural generated endophytes is due close relationship between host plants. The separated from usually classified steroids, xanthones, terpenoids, isocoumarins, phenols, tetralones, benzopyranones enniatines. Moreover, review discusses enhancement methods secondary metabolites production fungal which include optimization methods, co-culture method, chemical epigenetic modification molecular-based approaches. Furthermore, deals with different medical such antimicrobial, antiviral, antioxidant anticancer activities in last 3 years.
Язык: Английский
Процитировано
115
Microbial Ecology, Год журнала: 2023, Номер 86(3), С. 1455 - 1486
Опубликована: Март 14, 2023
Abstract Globally, substantial research into endophytic microbes is being conducted to increase agricultural and environmental sustainability. Endophytic such as bacteria, actinomycetes, fungi inhabit ubiquitously within the tissues of all plant species without causing any harm or disease. Endophytes form symbiotic relationships with diverse can regulate numerous host functions, including resistance abiotic biotic stresses, growth development, stimulating immune systems. Moreover, endophytes play a dominant role in nutrient cycling, biodegradation, bioremediation, are widely used many industries. have stronger predisposition for enhancing mineral metal solubility by cells through secretion organic acids low molecular weight metal-specific ligands (such siderophores) that alter soil pH boost binding activity. Finally, synthesize various bioactive compounds high competence promising candidates new drugs, antibiotics, medicines. Bioprospecting novel secondary metabolites has given momentum sustainable agriculture combating stresses. Biotechnological interventions aid played pivotal crop improvement mitigate stress conditions like drought, salinity, xenobiotic compounds, heavy metals. Identification putative genes from conferring tolerance diseases, apart those involved accumulation degradation contaminants, could open avenues development. Furthermore, detailed biochemical understanding endophyte entry colonization strategy would better help manipulating productivity under changing climatic conditions. Therefore, present review highlights current trends based on SCOPUS database, potential biotechnological microorganisms stresses influencing productivity, future opportunities improving tolerance, their contribution remediation hazardous contaminants. Graphical
Язык: Английский
Процитировано
109
Fungal Diversity, Год журнала: 2022, Номер 117(1), С. 1 - 272
Опубликована: Ноя. 1, 2022
Язык: Английский
Процитировано
98
Frontiers in Microbiology, Год журнала: 2023, Номер 14
Опубликована: Июль 11, 2023
Endophytic fungi comprise host-associated fungal communities which thrive within the tissues of host plants and produce a diverse range secondary metabolites with various bioactive attributes. The such as phenols, polyketides, saponins, alkaloids help to mitigate biotic abiotic stresses, fight against pathogen attacks enhance plant immune system. We present an overview association endophytic discuss molecular mechanisms induced during their symbiotic interaction. focuses on (especially those terpenoid nature) secreted by respective function. recent advancement in multi-omics approaches paved way for identification these characterization via comparative analysis extensive omics datasets. This study also elaborates role associated key agricultural crops hence important sustainability agriculture.
Язык: Английский
Процитировано
65
Drug Delivery and Translational Research, Год журнала: 2024, Номер 14(10), С. 2845 - 2916
Опубликована: Июль 13, 2024
Abstract Several efforts have been extensively accomplished for the amelioration of cancer treatments using different types new drugs and less invasives therapies in comparison with traditional therapeutic modalities, which are widely associated numerous drawbacks, such as drug resistance, non-selectivity high costs, restraining their clinical response. The application natural compounds prevention treatment cells has attracted significant attention from pharmaceuticals scientific communities over past decades. Although use nanotechnology therapy is still preliminary stages, nanotherapeutics demonstrated to decrease various limitations related compounds, physical/chemical instability, poor aqueous solubility, low bioavailability. Despite emerged a promise improve bioavailability there limited trials performed challenges required pre-clinical trials, production at an industrial level, assurance long-term stability, physiological barriers safety regulatory issues. This review highlights most recent advances nanocarriers secreted plants, bacteria, fungi, marine organisms, well role on cell signaling pathways anticancer treatments. Additionally, status main regarding loaded applications were also discussed. Graphical abstract
Язык: Английский
Процитировано
25
Biology, Год журнала: 2022, Номер 11(10), С. 1390 - 1390
Опубликована: Сен. 23, 2022
Endophytic bacteria are plant-beneficial with a broad host range. They provide numerous benefits to their hosts, helping them tolerate several biotic and abiotic stresses. An interest has recently been developed in endophytic which producing bioactive compounds that contribute the biological control of various phytopathogens. This research paper aimed investigate potentiality new local strains such as Bacillus amyloliquefaciens B. velezensis production antimicrobial metabolites associated biocontrol Alternaria sp., cause serious diseases affect important vegetable crops Egypt. Twenty-five isolates were obtained from different plants cultivated El-Sharkia Governorate, Dual culture technique was used evaluate bacterial isolates' antagonistic against sp. Helminthosporium The most active selected for further screening. antifungal activity isolate assessed vivo on pepper seedlings agent A significant recorded C1 T5 endophyte discs showed highest inhibitory effect at 4.7 3.1 cm, respectively, 3.9 4.0 respectively. identified 16S rRNA sequence submitted NCBI GenBank database accession numbers: MZ945930 MZ945929 velezensis, deformity pathogenic fungal mycelia studied under stress bacteria. filtrates extracted solvents, results indicated hexane efficient. Gas Chromatography-Mass Spectrometry revealed Bis (2-ethylhexyl) phthalate, ester, N,N-Dimethyldodecylamine major constituents crude extracts velezensis. infection caused disease incidence, leading high reduction plant height fresh dry weights plants. With application, DI significantly diminished compared infected plants, resulting an increase morphological parameters. Our findings allow chemical pesticide use some diseases.
Язык: Английский
Процитировано
45
Biomolecules, Год журнала: 2023, Номер 13(7), С. 1038 - 1038
Опубликована: Июнь 25, 2023
The seminal discovery of paclitaxel from endophytic fungus Taxomyces andreanae was a milestone in recognizing the immense potential fungi as prolific producers bioactive secondary metabolites use medicine, agriculture, and food industries. Following paclitaxel, research community has intensified efforts to harness putative lead molecules with anticancer, anti-inflammatory, antimicrobial, antioxidant, cardio-protective, immunomodulatory properties. Endophytic have been valuable source compounds over last three decades. Compounds such taxol, podophyllotoxin, huperzine, camptothecin, resveratrol effectively isolated characterized after extraction fungi. These findings expanded applications medicine related fields. In present review, we systematically compile analyze several important derived fungi, encompassing period 2011 2022. Our systematic approach focuses on elucidating origins exploring structural diversity biological activities exhibited by these compounds, giving special emphasis pharmacological mechanism action certain compounds. We highlight tremendous alternate sources metabolites, implications for combating major global diseases. This underscores significant role that can play development novel therapeutic agents address challenges posed prevalent diseases worldwide.
Язык: Английский
Процитировано
41
Scientific African, Год журнала: 2023, Номер 20, С. e01594 - e01594
Опубликована: Фев. 20, 2023
Endophytic fungi are naturally found within plants' tissues and cause no detectable disease symptoms in the plant. However, it is believed to possess supporting ecological physiological benefits for The confer their host plant profound resistance various pathogenic, parasitic, pest attach by augmenting plant's growth rate improving adaptability tolerance pests pathogens. Furthermore, relationships between fungal endophytes help synthesise varieties of biologically important secondary metabolites. Many these metabolites have shown antibiotic pest-repellant properties. In contrast, others imbued adaptive properties withstand environmental stress such as drought, significant variation temperature, salinity heavy metal accumulation. recent years, interest has shifted propensity produce new unique compounds with bioactive These include anticancer, antimicrobials, immunosuppressant antioxidant functions. could become future medicine, agriculture industrialisation revolutions, based on all possible biochemical produced endophytes.
Язык: Английский
Процитировано
37
Planta, Год журнала: 2023, Номер 257(4)
Опубликована: Март 1, 2023
Язык: Английский
Процитировано
29
Frontiers in Plant Science, Год журнала: 2023, Номер 14
Опубликована: Июль 10, 2023
The most significant issues that humans face today include a growing population, an altering climate, reliance on pesticides, the appearance of novel infectious agents, and accumulation industrial waste. production agricultural goods has also been subject to great number shifts, often known as revolutions, which have influenced by progression civilization, technology, general human advancement. Sustainable measures can be applied in agriculture, environment, medicine, industry are needed lessen harmful effects aforementioned problems. Endophytes, might bacterial or fungal, could successful solution. They protect plants promote growth producing phytohormones providing biotic abiotic stress tolerance. Endophytes produce diverse type bioactive compounds such alkaloids, saponins, flavonoids, tannins, terpenoids, quinones, chinones, phenolic acids etc. for various therapeutic advantages anticancer, antitumor, antidiabetic, antifungal, antiviral, antimicrobial, antimalarial, antioxidant activity. Proteases, pectinases, amylases, cellulases, xylanases, laccases, lipases, other types enzymes vital many different industries produced endophytes. Due presence all these endophytes, they preferred sources green synthesis nanoparticles. This review aims comprehend contributions uses endophytes medicinal, sectors bio-nanotechnology with their mechanism action.
Язык: Английский
Процитировано
25