Vietnam Journal of Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 13, 2024
Abstract
Fungi
are
one
of
the
richest
sources
bioactive
metabolites,
which
can
be
used
to
produce
innovative
therapeutic
agents.
Pleosporales
sp.
including
epiphytic,
endophytic,
or
parasitic
species
yield
diverse
secondary
metabolites
widely
spread
throughout
many
ecosystems.
These
classified
into
polyketides,
alkaloids,
sesquiterpenoids,
diterpenoids,
steroids,
and
others
depending
on
their
unique
structural
characteristics.
Secondary
produced
by
displayed
outstanding
biological
activities
such
as
cytotoxic,
antibacterial,
antifungal,
anti‐inflammatory
properties.
The
goal
this
review
was
compile
most
recent,
comprehensive
literature
data
metabolite
classes
sp.,
backed
its
various
bioactivity
data,
a
scientific
record
for
upcoming
drug
discovery
endeavors.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2022,
Номер
63(32), С. 11125 - 11152
Опубликована: Июнь 16, 2022
Global
crop
and
food
contamination
with
mycotoxins
are
one
of
the
primary
worldwide
concerns,
while
there
several
restrictions
regarding
approaching
conventional
physical
chemical
decontamination
methods
due
to
nutrition
loss,
sensory
attribute
reduction
in
foods,
residual,
inconvenient
operation,
high
cost
equipment,
energy
consumption
some
methods.
In
this
regard,
overarching
challenges
mycotoxin
crops
require
development
biological
strategies.
Using
certain
lactic
acid
bacteria
(LAB)
as
generally
recognized
safe
(GRAS)
compounds
is
most
effective
alternatives
their
potential
release
antifungal
metabolites
against
various
fungal
factors
species.
This
review
highlights
applications
LAB
biodetoxificant
agents
summarizes
activities
Fusarium
growth
released
into
food/feed.
Firstly,
occurrence
instrumental
bioanalytical
for
analysis
were
in-depth
discussed.
Upgraded
knowledge
on
biosynthesis
pathway
produced
by
offers
new
insightful
ideas
clarifying
function
these
secondary
metabolites.
Moreover,
characterization
impact
from
Fusarium,
besides
main
mechanisms
decontamination,
covered.
While
thematic
inhibition
very
complex,
worth
deeper
investigations.
Journal of Fungi,
Год журнала:
2022,
Номер
8(5), С. 504 - 504
Опубликована: Май 12, 2022
Fungi
are
renowned
as
a
fountainhead
of
bio-metabolites
that
could
be
employed
for
producing
novel
therapeutic
agents,
well
enzymes
with
wide
biotechnological
and
industrial
applications.
Stachybotrys
chartarum
(black
mold)
(Stachybotriaceae)
is
toxigenic
fungus
commonly
found
in
damp
environments.
This
has
the
capacity
to
produce
various
classes
unrivaled
structural
features,
including
cyclosporins,
cochlioquinones,
atranones,
trichothecenes,
dolabellanes,
phenylspirodrimanes,
xanthones,
isoindoline
chromene
derivatives.
Moreover,
it
source
have
variable
relevance.
The
current
review
highlights
formerly
published
data
on
S.
chartarum,
its
metabolites
their
bioactivities,
relevance
dated
from
1973
beginning
2022.
In
this
work,
215
been
listed
138
references
cited.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(19), С. 10970 - 10980
Опубликована: Май 6, 2024
Eleven
alkaloids
(1–11)
including
seven
new
ones,
1–7,
were
isolated
from
the
solid
fermentation
of
Aspergillus
fumigatus
VDL36,
an
endophytic
fungus
leaves
Vaccinium
dunalianum
Wight
(Ericaceae),
a
perennial
evergreen
shrub
distributed
across
Southwest
regions
China,
Myanmar,
and
Vietnam.
Their
structures
elucidated
on
basis
extensive
spectroscopic
methods.
The
isolates
evaluated
for
in
vitro
antifungal
activities
against
five
phytopathogenic
fungi
(Fusarium
oxysporum,
Coriolus
versicolor,
Fusarium
solani,
Botrytis
cinerea,
graminearum).
As
result,
compounds
fumigaclavine
I
(1),
13-ethoxycyclotryprostatin
A
(5),
13-dehydroxycyclotryprostatin
(6),
12β-hydroxy-13-oxofumitremorgin
C
(7)
exhibited
with
MIC
values
7.8–62.5
μg/mL
which
comparable
to
two
positive
controls
ketoconazole
(MIC
=
7.8–31.25
μg/mL)
carbendazim
1.95–7.8
μg/mL).
Furthermore,
1
5
demonstrated
potent
protective
curative
effects
tomato
gray
mold
vivo.
Preliminary
structure–activity
relationships
tested
indole
diketopiperazine
indicate
that
introduction
substituent
group
at
position
C-13
enhances
their
biological
activities.
Molecules,
Год журнала:
2022,
Номер
27(19), С. 6759 - 6759
Опубликована: Окт. 10, 2022
Fungus
continues
to
attract
great
attention
as
a
promising
pool
of
biometabolites.
Aspergillus
ochraceus
Wilh
(Aspergillaceae)
has
established
its
capacity
biosynthesize
myriad
metabolites
belonging
different
chemical
classes,
such
isocoumarins,
pyrazines,
sterols,
indole
alkaloids,
diketopiperazines,
polyketides,
peptides,
quinones,
and
sesquiterpenoids,
revealing
various
bioactivities
that
are
antimicrobial,
cytotoxic,
antiviral,
anti-inflammatory,
insecticidal,
neuroprotective.
Additionally,
A.
produces
variety
enzymes
could
have
variable
industrial
biotechnological
applications.
From
1965
until
June
2022,
165
were
reported
from
isolated
sources.
In
this
review,
the
formerly
separated
ochraceus,
including
their
biosynthesis,
in
addition,
potential
highlighted.
Life,
Год журнала:
2022,
Номер
12(3), С. 384 - 384
Опубликована: Март 7, 2022
Two
new
benzophenones:
garcimangophenones
A
(6)
and
B
(7)
five
formerly
reported
metabolites
were
purified
from
the
pericarps
EtOAc
fraction
of
Garcinia
mangostana
((GM)
Clusiaceae).
Their
structures
characterized
by
various
spectral
techniques
comparing
with
literature.
The
α-amylase
inhibitory
(AAI)
potential
isolated
was
assessed.
Compounds
7
6
had
significant
AAI
activity
(IC50
9.3
12.2
µM,
respectively)
compared
acarbose
6.4
reference
inhibitor).
On
other
hand,
5
a
moderate
activity.
Additionally,
their
towards
assessed
utilizing
docking
studies
molecular
dynamics
(MD)
simulations.
predictive
binding
energy
estimations
accomplished
using
crystal
structure
(PDB
ID:
5TD4).
possessed
highly
negative
scores
-11.3
-8.2
kcal/mol,
when
complexed
5TD4,
respectively
while
score
-16.1
5TD4.
By
simulations,
compounds
stability
in
complexes
analyzed,
it
found
to
be
stable
over
course
50
ns.
results
suggested
that
benzophenone
derivative
may
inhibitors.
However,
further
investigations
support
these
findings
are
required.
RSC Advances,
Год журнала:
2023,
Номер
13(34), С. 23472 - 23498
Опубликована: Янв. 1, 2023
Fungi
have
protruded
with
enormous
development
in
the
repository
of
drug
discovery,
making
them
some
most
attractive
sources
for
synthesis
bio-significant
and
structural
novel
metabolites.
