Challenges and update on fungal endophytes: classification, definition, diversity, ecology, evolution and functions

Fungal Diversity, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

Язык: Английский

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Fungal secondary metabolites in food and pharmaceuticals in the era of multi-omics

Applied Microbiology and Biotechnology, Год журнала: 2022, Номер 106(9-10), С. 3465 - 3488

Опубликована: Май 1, 2022

Fungi produce several bioactive metabolites, pigments, dyes, antioxidants, polysaccharides, and industrial enzymes. Fungal products are also the primary sources of functional food nutrition, their pharmacological used for healthy aging. Their molecular properties validated through use recent high-throughput genomic, transcriptomic, metabolomic tools techniques. Together, these updated multi-omic have been to study fungal metabolites structure mode action on biological cellular processes. Diverse groups fungi different proteins secondary which possess tremendous biotechnological pharmaceutical applications. Furthermore, its acceptability can be accelerated by adopting multi-omics, bioinformatics, machine learning that generate a huge amount data. The integration artificial intelligence in era omics big data has opened up new outlook both basic applied researches area nutraceuticals nutrition. KEY POINTS: • Multi-omic tool helps identification novel Intra-omic from genomics bioinformatics Novel application human health.

Язык: Английский

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Antibacterial and Antifungal Sesquiterpenoids: Chemistry, Resource, and Activity

Biomolecules, Год журнала: 2022, Номер 12(9), С. 1271 - 1271

Опубликована: Сен. 9, 2022

Infectious diseases caused by bacteria and fungi are threatening human health all over the world. It is an increasingly serious problem that efficacies of some antibacterial antifungal agents have been weakened drug resistance fungi, which makes a great need for new antibiotics. Sesquiterpenoids, with abundant structural skeleton types wide range bioactivities, considered as good candidates to be agents. In past decades, many sesquiterpenoids were isolated from plants exhibited activities. this review, names, source, structures, degrees, mechanisms activity 2012 2022 summarized, structure-activity relationship these against also discussed.

Язык: Английский

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Light-absorption-driven photocatalysis and antimicrobial potential of PVP-capped zinc oxide nanoparticles

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Авг. 24, 2023

Toxic dyes in water bodies and bacterial pathogens pose serious global challenges to human health the environment. Zinc oxide nanoparticles (ZnO NPs) demonstrate remarkable photocatalytic antibacterial potency against reactive strains. In this work, PVP-ZnO NPs have been prepared via co-precipitation method using polyvinylpyrrolidone (PVP) as a surfactant. The NPs' microstructure morphology were studied X-ray diffraction (XRD), having size of 22.13 nm. High-resolution transmission electron microscope (HR-TEM) field emission scanning microscopy (FESEM) analysis showed spherical-shaped with sizer ranging from 20 30 Fourier Transform Infrared Spectroscopy (FT-IR) confirmed hybrid nature NPs, UV-Vis spectroscopy an absorption peak at 367 exhibited high activity, achieving 88% nearly 95% degradation red-141 azo dye 10 mg catalyst dosages, respectively. properties demonstrated Escherichia coli Bacillus subtilis, inhibition zones 24 mm mm, These findings suggest that can be effectively used for treatment, targeting both pathogenic contaminants.

Язык: Английский

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Antimicrobial Action Mechanisms of Natural Compounds Isolated from Endophytic Microorganisms

Antibiotics, Год журнала: 2024, Номер 13(3), С. 271 - 271

Опубликована: Март 18, 2024

Infectious diseases are a significant challenge to global healthcare, especially in the face of increasing antibiotic resistance. This urgent issue requires continuous exploration and development new antimicrobial drugs. In this regard, secondary metabolites derived from endophytic microorganisms stand out as promising sources for finding antimicrobials. Endophytic microorganisms, residing within internal tissues plants, have demonstrated capacity produce diverse bioactive compounds with substantial pharmacological potential. Therefore, numerous been isolated endophytes, particularly fungi actinomycetes. However, only limited number these subjected comprehensive studies regarding their mechanisms action against bacterial cells. Furthermore, investigation effects on antibiotic-resistant bacteria identification biosynthetic gene clusters responsible synthesizing conducted subset compounds. Through analysis current research findings, review describes drugs antibacterial activities natural endophytes bacteria, synthesis metabolites.

Язык: Английский

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Synergistic partnerships of endophytic fungi for bioactive compound production and biotic stress management in medicinal plants

Plant Stress, Год журнала: 2024, Номер 11, С. 100425 - 100425

Опубликована: Март 1, 2024

The fungal endophytes are an understudied area of research with great potential for new bioactive compounds' discovery. These the strains that live within inner compartments host plant without causing it any kind harm. endophytes, in combination organisms, synthesize many compounds a range pharmaceutical values. Most recently, discovery endophyte genes which linked biosynthesis metabolites has opened field research. partners assist plants against biotic stress and protect them from pathogenic attacks or diseases presence some important gene families like WRKY MYB. this group known their anticancer, antimicrobial, antioxidant, antidiabetic, anti-tubercular properties. Therefore, these offer routes discovering novel drugs, can boost industry times demand drugs. Extracellular enzymes also produced members distinct crucial several industrial sectors, including biofuel production industry. Furthermore, capable synthesizing silver nanoparticles, exhibit significant fields biomedical imaging water purification. This article aims to document all available data on fungi living medicinal major by use therapy various ailments.

Язык: Английский

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Terricoxanthones A–E, unprecedented dihydropyran-containing dimeric xanthones from the endophytic fungus Neurospora terricola HDF-Br-2 associated with the vulnerable conifer Pseudotsuga gaussenii

Phytochemistry, Год журнала: 2024, Номер 219, С. 113963 - 113963

Опубликована: Янв. 1, 2024

Язык: Английский

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Recent Advances in Using Natural Antibacterial Additives in Bioactive Wound Dressings

Pharmaceutics, Год журнала: 2023, Номер 15(2), С. 644 - 644

Опубликована: Фев. 14, 2023

Wound care is a global health issue with financial burden of up to US $96.8 billion annually in the USA alone. Chronic non-healing wounds which show delayed and incomplete healing are especially problematic. Although there more than 3000 dressing types wound management market, new developments efficient dressings will require innovative approaches such as embedding antibacterial additives into wound-dressing materials. The lack novel agents misuse current antibiotics have caused an increase antimicrobial resistance (AMR) estimated cause 10 million deaths by 2050 worldwide. These ongoing challenges clearly indicate urgent need for developing targeting microbial pathogens. Natural products their derivatives long been significant source pharmaceuticals against AMR. Scrutinising data newly approved drugs has identified plants one biggest most important sources development drugs. Some plant-based additives, essential oils plant extracts, previously used dressings; however, another plant-derived i.e., those produced symbiotic endophytic fungi, that great potential applications. Endophytes represent novel, natural, sustainable bioactive compounds therapeutic applications, including chronic dressings. This review examines appraises recent incorporate natural well advances endophyte research treating wounds.

Язык: Английский

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Health-Promoting Effects of Bioactive Compounds from Plant Endophytic Fungi

Journal of Fungi, Год журнала: 2023, Номер 9(10), С. 997 - 997

Опубликована: Окт. 8, 2023

The study examines the intricate relationship between plants and endophytic fungi inhabiting their tissues. These harmoniously coexist with plants, forming a distinct symbiotic connection that has caught scientific attention due to its potential implications for plant health growth. diverse range of bioactive compounds produced by these holds significant promise human health. review covers various aspects this topic, starting introducing microorganisms, explaining colonization different parts, illuminating roles in enhancing defense against diseases promoting emphasizes widespread occurrence diversity microorganisms among species while highlighting complexities significance isolating extracting from them. It focuses on benefits compounds, including capacity exhibit antioxidant, anti-inflammatory, antimicrobial, anticancer effects. delves into mechanisms behind health-promoting effects, spotlighting how interact cellular receptors, signaling pathways, gene expression. In conclusion, provides comprehensive overview fungi. outlines multifaceted impact, applications, future research avenues medicine.

Язык: Английский

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Talaromyces purpureogenus CEF642^N as a Promising Biocontrol Agent for Cotton Disease Control

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Endophytic fungi live in healthy plant tissues and organs are a major source of natural bioactive compounds. In this study, we found that an endophytic fungus, Talaromyces purpureogenus CEF642N, isolated from the cotton roots, suppressed Verticillium dahliae by up to 53% after 15 days confrontation culture. Genome sequencing CEF642N mass spectrometry study its metabolites were used identify primary antagonists. To further elucidate antagonistic mechanism, transcriptome analysis ultrastructure observation pathogen performed. The antagonists shown act on mitochondria cell membranes pathogen. addition, also had mycoparasitic effects V. dahliae. These results suggest has potential be important biocontrol agent for efficiently managing wilt, severe disease affecting cotton.

Язык: Английский

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