Confronting a New Challenge in Plastic Surgery: MDR Infections in Patients with Chronic Wounds

Life, Год журнала: 2024, Номер 14(4), С. 444 - 444

Опубликована: Март 27, 2024

Background: The presence of a wound can be anywhere from non-problematic to life-threatening on severity spectrum, with bacterial infection and resistance playing major role in the development chronicity, delaying healing. Wound colonization multiple organisms limited number effective antibiotics place heavy burden healthcare system, patients going through surgeries during prolonged hospitalization time. By analyzing patterns pluri-bacterial populations approach used managing complex cases, we aim improve protocols applied caring for chronic wounds our practice share experiences observations. Methods: We designed retrospective study 212 diabetic non-diabetic patients, aiming evaluate course treatment practice. focused impact that MDR bacteria diabetes have surgical outcomes their healing process. Results: Patients who received empiric antibiotic therapy before being admitted eventually presented compared those did not receive (p = 0.014). at least one bed was associated ulcers reaching bone 0.02) positively correlated performed < 0.001). Diabetes played significant surgery-related complications time Conclusions: Proper management requires comprehensive, multidisciplinary thorough understanding usage. To address this need, developed implemented protocol clinic, goal discharging once been treated closed. A key summary is reduce incidence patient’s quality life.

Язык: Английский

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Strategies for Optimizing Acute Burn Wound Therapy: A Comprehensive Review

Medicina, Год журнала: 2025, Номер 61(1), С. 128 - 128

Опубликована: Янв. 15, 2025

Recent advancements in acute burn wound therapy are transforming the management of injuries, with a focus on improving healing times, graft integration, and minimizing complications. However, current clinical treatments face significant challenges, including difficulty accurately assessing depth tissue viability, which can lead to suboptimal treatment planning. Traditional closure methods often struggle issues such as delayed closure, limited survival, inadequate regeneration, insufficient vascularization. Furthermore, managing infection scarring remain persistent obstacles, impacting functional recovery aesthetic outcomes. Key areas innovation include advanced imaging techniques that enable more precise assessment depth, size, allowing for accurate In addition, new strategies being developed accelerate enhance address challenges vascularization, prevention. These aim optimize both outcomes, reducing quality life patients. While promising, these emerging require further research validation refine their effectiveness expand accessibility. Together, innovations represent shift care, offering potential personalized, efficient, effective treatments.

Язык: Английский

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Optimization and advances in negative pressure wound therapy for the management of necrotizing fasciitis in the upper limb

World Journal of Orthopedics, Год журнала: 2025, Номер 16(3)

Опубликована: Март 12, 2025

Язык: Английский

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Comparative Study of Negative Pressure Wound Therapy and Silver-releasing Foam Dressings in the Management of Diabetic Foot Ulcers

Indus journal of bioscience research., Год журнала: 2025, Номер 3(3), С. 491 - 496

Опубликована: Март 29, 2025

Introduction: Diabetic foot ulcers (DFUs) can be defined as a major complication of Diabetes Mellitus that often results in infections and amputations. Wound care is outmost importance, for with appropriate management, further problems do not occur the wound heals. Negative Pressure Therapy (NPWT) silver-releasing foam dressings are two modalities management DFUs. Objectives: This proposal sought to determine effectiveness NPWT healing diabetic reduction ulcer size over six-week period. Materials Methods: study was quasi-experimental, 120 patients across PNS Hafeez Hospital Islamabad were selected. Patients randomly allocated either group or dressing group. They include time taken wounds heal period six weeks. Results: achieved faster 19.7 days had greater percentage mean area reduction, 38.7%, than 24.9 26.5%, respectively. Conclusion: confirms more effective reducing DFU accelerating healing. promotes re-epithelialization due its vacuum effect. However, drug-releasing remain beneficial, especially when unavailable. Treatment choice should consider patient needs resources. Further research larger samples longer observation needed validate these findings assess long-term impacts.

Язык: Английский

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Navigating the Complexities of Radiation Injuries: Therapeutic Principles and Reconstructive Strategies

Journal of Personalized Medicine, Год журнала: 2024, Номер 14(11), С. 1100 - 1100

Опубликована: Ноя. 9, 2024

Radiation injuries, particularly those resulting from therapeutic or accidental exposure, present complex challenges for medical management. These injuries can manifest localized skin damage extend to deeper tissues, presenting as various clinical entities that require treatment strategies, ranging conservative management surgical interventions. constitutes a fundamental component of neoplastic management, with nearly two out three oncological instances undergoing it an element their strategy. The approach radiation injury consists expanding prophylactic measures while maintaining the efficacy treatment, such local debridement followed by reconstruction. armamentarium reconstructive methods available plastic surgeons, secondary healing free tissue transfer, be successfully applied injuries. However, unique pathophysiological changes induced necessitate careful and specialized application, considering altered characteristics dynamics. strategy is guided both severity progression injury, primary aim restoring functionality aesthetic aspects simultaneously minimizing risk complications. This paper explores conditions encompassed term "radiation injury," reviews non-surgical strategies managing these highlights associated treating irradiated tissues within specific contexts.

Язык: Английский

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Our Experience and Clinical Findings in Perineal Burns: Implications for Patient Prognosis—A 3 Year Retrospective Study

Medicina, Год журнала: 2024, Номер 60(12), С. 2009 - 2009

Опубликована: Дек. 5, 2024

Background and Objectives: Burn injury represents a very important public health problem that affects all age groups. Of burns, of particular interest is the perineum. Despite importance subject, unfortunately, medical literature on this anatomical region sparse. With study we aim to analyze characteristics burns affecting perineal area, physiopathologic implications injury, influence patient prognosis, possible complications therapeutic guidelines. Materials Methods: This formed by retrospective analysis cases were admitted over period spanning 3 years with total 258 burned patients. After inclusion criteria, selected 49 patients who had compared group non-perineal lot 198 (11 excluded). We studied their demographical aspects deemed most condition: age, sex, burn percentage body surface area (TBSA), third-degree lesions, comorbidities, associated infections, inhalation injuries calculated significant scores such as Abbreviated Severity Index score (ABSI). Results: The in our mostly severe extensive (64.9% mean TBSA) which also underlined ABSI 10.88 ± 2.46 thus having poor prognosis considering presence injuries. In study, usually adjacent regions abdominal wall comprising 51% thigh 97.9% relationship both explains higher TBSA underlines issues derive from perineum several lead an unbalance treatment still remains much debated when indications can become rather complex sequelae setting. Conclusions: issue one subjects plastic surgery. Being hard treat but big evolution survival chances prevention key factor.

Язык: Английский

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Bromelain in Burn Care: Advancements in Enzymatic Debridement and Patient Outcomes

European Burn Journal, Год журнала: 2024, Номер 5(4), С. 438 - 453

Опубликована: Дек. 12, 2024

The management of severe burns is a complex process that requires multidimensional approach to ensure optimal healing burn wounds, minimize complications, and improve the prognosis patients. Surgical debridement considered gold standard for removing necrotic tissue; however, this involves risks such as bleeding, potential removal viable tissue during excision, technical challenges in anatomical areas. Recent advancements highlight role enzymatic using NexoBrid®, which offers less invasive alternative surgical excision while having ability selectively debride preserve tissue. NexoBrid® has shown efficacy reducing time, minimizing need additional surgeries, improving overall wound outcomes. This review discusses clinical indications, advantages, considerations choosing between debridement. Emerging studies suggest be safe effective even larger areas, making it promising option modern care. However, ongoing evaluation integration into protocols will essential fully realize its benefits specialized treatment establish protocols.

Язык: Английский

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Assessing Donor Site Morbidity and Impact on Quality of Life in Free Flap Microsurgery: An Overview

Life, Год журнала: 2024, Номер 15(1), С. 36 - 36

Опубликована: Дек. 30, 2024

Donor site morbidity remains a significant concern in free flap microsurgery, with implications that extend beyond immediate postoperative outcomes to affect patients’ long-term quality of life. This review explores the multi-faceted impact donor on physical, psychological, social, and occupational well-being, synthesizing findings from existing literature. Particular attention is given functional limitations, sensory deficits, aesthetic outcomes, chronic pain associated commonly utilized flaps. Advancements surgical techniques, including nerve-sparing muscle-sparing methods, as well innovations, like perforator flaps, have demonstrated potential mitigate these morbidities. Furthermore, integration regenerative medicine strategies, such stem cell therapy fat grafting, technological virtual reality rehabilitation biofeedback devices, has shown promise enhancing recovery minimizing complications. Despite advances, challenges persist standardizing QoL assessments optimizing management. emphasizes need for holistic, patient-centered approach reconstructive advocating further research refine current improve develop robust tools evaluation. By addressing gaps, surgeons can better align objectives comprehensive well-being their patients.

Язык: Английский

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Clinicopathological Findings and Comprehensive Review of Buschke–Lowenstein Tumors Based on a Case Study

Journal of Personalized Medicine, Год журнала: 2024, Номер 14(8), С. 887 - 887

Опубликована: Авг. 22, 2024

The Buschke-Löwenstein tumor (BLT), also known as giant condyloma acuminatum, is a rare, exophytic tumor, arising from pre-existing warty lesions associated with human papillomavirus (HPV) infection, particularly strains 6 and 11, which are considered to have low oncogenic potential. BLT presents large, cauliflower-like growth typically affecting the penis, vulva, vagina, perineum, scrotum, anus, perianal area. Despite being benign lesion, locally aggressive high recurrence rate, can potentially undergo malignant transformation into squamous cell carcinoma, contributing an overall mortality rate of 20-30%. primary treatment complete surgical excision wide margins, frequently requiring complex reconstructive techniques for defect coverage. We report on 68-year-old patient, multiple comorbidities, who presented two-year history large in genital region, along progressive erectile dysfunction urinary problems. was surgically excised oncological safety reconstruction performed using advancement rotation flaps scrotum intact penile skin. Histopathological examination confirmed diagnosis Giant Condyloma (Buschke-Löwenstein tumor), showing acanthosis, papillomatosis, parakeratosis, koilocytic collections, positive immunohistochemical staining p16, p63, ki67. Postoperatively, patient had good clinical outcome cure. This case highlights critical need timely intervention comprehensive management strategies treating condyloma, given its potential local invasion substantial impacts quality life. Early thorough crucial effective reduce recurrence, morbidity risk this condition.

Язык: Английский

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Topical treatment of skin diseases with bioactive inorganic nanomaterials: Beyond drug delivery

Next Materials, Год журнала: 2024, Номер 6, С. 100401 - 100401

Опубликована: Окт. 22, 2024

Язык: Английский

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