BDNF/BDNF-AS Gene Polymorphisms Modulate Treatment Response and Remission in Bipolar Disorder: A Randomized Clinical Trial
Journal of Personalized Medicine,
Год журнала:
2025,
Номер
15(2), С. 62 - 62
Опубликована: Фев. 7, 2025
Background:
Bipolar
disorder
(BD)
is
a
chronic
condition
associated
with
treatment
resistance,
cognitive
decline,
structural
brain
changes,
and
an
approximately
13-year
reduction
in
life
expectancy
compared
to
the
general
population.
Depression
BD
substantially
impairs
quality
of
life,
while
neuroinflammation
excitotoxicity
are
thought
contribute
recurrence
mood
episodes
disease
progression.
Brain-derived
neurotrophic
factor
(BDNF)
plays
key
role
neuronal
growth
function,
its
dysregulation
being
linked
various
psychiatric
disorders.
This
study
extension
previously
published
clinical
trial
was
conducted
assess
effects
three
BDNF
BDNF-AS
gene
polymorphisms
(rs1519480,
rs6265,
rs10835210)
on
outcomes
serum
levels
patients
treatment-resistant
bipolar
depression
(TRBDD)
over
eight-week
period.
Methods:
included
41
participants
from
randomized
trial,
all
whom
had
available
samples
genotype
data.
The
participants,
aged
21
65,
were
diagnosed
disorder,
assessed
using
Maudsley
Staging
Method.
Participants
randomly
assigned
receive
either
escitalopram
plus
placebo
(ESC+PBO)
or
celecoxib
(ESC+CBX)
8-week
Statistical
analyses
mixed
ANOVA
chi-square
tests
compare
minor
allele
carrier
status
SNPs
response
remission
rates.
Results:
Non-carriers
rs6265
A
(p
=
0.005)
carriers
rs10835210
0.007)
showed
significantly
higher
adjunctive
alone.
Additionally,
rates
after
both
non-carriers
across
However,
notably
rs1519480
G
allele,
as
well
allele.
Conclusions:
suggests
that
genetic
variations
genes
influence
disorder.
Язык: Английский
Mitochondrially Transcribed dsRNA Mediates Manganese-induced Neuroinflammation
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 20, 2025
Abstract
Manganese
(Mn)
is
an
essential
trace
element
required
for
various
biological
functions,
but
excessive
Mn
levels
are
neurotoxic
and
lead
to
significant
health
concerns.
The
mechanisms
underlying
Mn-induced
neurotoxicity
remain
poorly
understood.
Neuropathological
studies
of
affected
brain
regions
reveal
astrogliosis,
neuronal
loss,
along
with
evidence
neuroinflammation.
Here,
we
present
a
novel
Mn-dependent
mechanism
linking
mitochondrial
dysfunction
We
found
that
disrupts
transcriptome
processing,
resulting
in
the
accumulation
complementary
RNAs
form
double-stranded
RNA
(dsRNA).
This
dsRNA
released
cytoplasm,
where
it
activates
cytosolic
sensor
pathways,
triggering
type
I
interferon
responses
inflammatory
cytokine
production.
100-day
human
cerebral
organoids,
observed
predominantly
mature
astrocytes.
Similar
effects
were
vivo
mouse
model
carrying
mutations
SLC30A10
gene,
which
results
accumulation.
These
findings
highlight
previously
unrecognized
role
neuroinflammation
provide
insights
into
molecular
basis
manganism.
propose
this
dsRNA-induced
pathway
has
broad
implications
neurodegenerative
diseases
caused
by
environmental
or
genetic
insults.
Язык: Английский
Targeting CXCR2 signaling in inflammatory lung diseases: neutrophil-driven inflammation and emerging therapies
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 6, 2025
Язык: Английский
Brain-derived neurotrophic factor and stress perception
Personalized Medicine in Psychiatry,
Год журнала:
2024,
Номер
47-48, С. 100139 - 100139
Опубликована: Окт. 15, 2024
Язык: Английский
Hemozoin induces malaria via activation of DNA damage, p38 MAPK and neurodegenerative pathways in a human iPSC-derived neuronal model of cerebral malaria
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Окт. 23, 2024
Abstract
Malaria
caused
by
Plasmodium
falciparum
infection
results
in
severe
complications
including
cerebral
malaria
(CM),
which
approximately
30%
of
patients
end
up
with
neurological
sequelae.
Sparse
vitro
cell
culture-based
experimental
models
recapitulate
the
molecular
basis
CM
humans
has
impeded
progress
our
understanding
its
etiology.
This
study
employed
healthy
human
induced
pluripotent
stem
cells
(iPSCs)-derived
neuronal
cultures
stimulated
hemozoin
(HMZ)
-
malarial
toxin
as
a
model
for
CM.
Secretome,
qRT-PCR,
Metascape,
and
KEGG
pathway
analyses
were
conducted
to
assess
elevated
proteins,
genes,
pathways.
Neuronal
treated
HMZ
showed
enhanced
secretion
interferon-gamma
(IFN-γ),
interleukin
(IL)1-beta
(IL-1β),
IL-8
IL-16.
Enrichment
analysis
revealed
malaria,
positive
regulation
cytokine
production
mitogen-activated
protein
kinase
(MAPK)
cascade
confirm
inflammatory
response
exposure.
assessment
up-regulation
MAPK
neurodegenerative
diseases-associated
pathways
corroborates
findings
from
previous
studies.
Additionally,
DNA
damage
neurons.
unveiled
that
exposure
HMZ,
activates
molecules
similar
those
observed
diseases.
Furthermore,
is
an
alternative
rodent
Язык: Английский
BDNF blood levels as a potential biomarker Predictor of treatment response and remission in bipolar depression
Personalized Medicine in Psychiatry,
Год журнала:
2024,
Номер
47-48, С. 100144 - 100144
Опубликована: Ноя. 1, 2024
Язык: Английский
The Identification of Key Genes and Biological Pathways in Cardiac Arrest by Integrated Bioinformatics and Next Generation Sequencing Data Analysis
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 19, 2024
Abstract
Cardiac
arrest
(CA)
is
a
common
cause
of
death
world
wide.
The
disease
has
lacks
effective
treatment.
Efforts
have
been
made
to
elucidate
the
molecular
pathogenesis
CA,
but
mechanisms
remain
elusive.
To
identify
key
genes
and
pathways
in
next
generation
sequencing
(NGS)
GSE200117
dataset
was
downloaded
from
Gene
Expression
Omnibus
(GEO)
database.
DESeq2
tool
used
recognize
differentially
expressed
(DEGs).
ontology
(GO)
REACTOME
pathway
enrichment
analyses
were
performed
analyze
DEGs
associated
signal
g:Profiler
IID
database
construct
protein-protein
interaction
(PPI)
network,
modules
analysis
using
Cytoscape.
A
miRNA-hub
gene
regulatory
network
TF-hub
then
constructed
screen
miRNAs,
TFs
hub
by
miRNet
NetworkAnalyst
Cityscape
software.
Receiver
operating
characteristic
curve
(ROC)
verified
genes.
In
total,
844
identified,
comprising
414
up
regulated
430
down
GO
indicated
that
for
CA
mainly
enriched
organonitrogen
compound
metabolic
process,
response
stimulus,
translation
immune
system.
Ten
(up-regulated:
HSPA8,
HOXA1,
INCA1
TP53;
down-regulated:
HSPB1,
LMNA,
SNCA,
ADAMTSL4
PDLIM7)
screened.
We
also
predicted
miRNAs
(hsa-mir-1914-5p
hsa-mir-598-3p)
(JUN
PRRX2)
targeting
This
study
uses
series
bioinformatics
technologies
obtain
hug
genes,
TFs,
related
CA.
These
results
provide
us
with
new
ideas
finding
biomarkers
treatment
methods
Язык: Английский