A Multi-Omics Analysis of a Mitophagy-Related Signature in Pan-Cancer

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 448 - 448

Опубликована: Янв. 7, 2025

Mitophagy, an essential process within cellular autophagy, has a critical role in regulating key functions such as reproduction, metabolism, and apoptosis. Its involvement tumor development is complex influenced by the environment. Here, we conduct comprehensive analysis of mitophagy-related gene signature, composed PRKN, PINK1, MAP1LC3A, SRC, BNIP3L, BECN1, OPTN, across various cancer types, revealing significant differential expression patterns associated with molecular subtypes, stages, patient outcomes. Pathway revealed interplay between signature potential effects on activity cancer-related pathways pan-cancer. Immune infiltration linked mitophagy certain immune cell particularly OPTN melanoma. Methylation correlated infiltration. Mutation also showed frequent alterations PRKN (34%), (21%), PINK1 (28%), SRC (15%), implications for microenvironment. We found correlations genes sensitivity different drugs, suggesting that targeting this could improve therapy efficacy. Overall, our findings underscore importance biology drug resistance, well its informing treatment strategies.

Язык: Английский

Characterization of Exhausted T Cell Signatures in Pan-Cancer Settings

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2311 - 2311

Опубликована: Март 5, 2025

T cells play diverse roles in cancer immunology, acting as tumor suppressors, cytotoxic effectors, enhancers of lymphocyte responses and immune suppressors; providing memory surveillance; modulating the microenvironment (TME); or activating innate cells. However, can disrupt cell function, leading to exhaustion a weakened response against tumor. The expression exhausted (Tex) markers plays pivotal role shaping landscape multiple cancers. Our aim was systematically investigate known across cancers while exploring their molecular interactions, mutation profiles, potential implications for immunotherapy. mRNA profile six Tex markers, LAG-3, PDCD1, TIGIT, HAVCR2, CXCL13, LAYN investigated pan-cancer. Utilizing data from Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Proteome (TCPA), other repositories, we characterized differential association with patients' survival outcome, Additionally, analyzed effects on cancer-related pathways infiltration within TME, offering valuable insights into mechanisms evasion progression. Finally, correlation between sensitivity anti-cancer drugs extensively. Differential all significantly associated KIRC poor prognosis several They also played apoptosis, EMT, hormone ER pathways, well inhibitory DNA damage RTK oncogenic pathways. Infiltration different found be Tex-related genes most types. These findings underline that reviving used enhance efficacy immunotherapy patients.

Язык: Английский