Nutrients, Год журнала: 2024, Номер 16(24), С. 4411 - 4411
Опубликована: Дек. 23, 2024
Noncoding RNAs, particularly microRNAs (miRNAs) and small interfering RNAs (siRNAs), have emerged as key players in the pathogenesis therapeutic strategies for inflammatory bowel disease (IBD). MiRNAs, endogenous RNA molecules that silence target mRNAs to regulate gene expression, are closely linked immune responses pathways IBD. Notably, miR-21, miR-146a, miR-155 consistently upregulated IBD, influencing cell modulation, cytokine production, intestinal epithelial barrier. These miRNAs serve biomarkers progression severity, well targets controlling inflammation. This comprehensive review highlights intricate interplay between gut microbiota, fecal microbiota transplantation (FMT), miRNA regulation. It concludes FMT influence activity, presenting a promising avenue personalized IBD treatment.
Язык: Английский