Renal Implications of Dysregulated Protein Homeostasis: Insights into Ubiquitin–Proteasome and Autophagy Systems DOI Creative Commons
Charlotte Delrue, Marijn M. Speeckaert

Biomolecules, Год журнала: 2025, Номер 15(3), С. 349 - 349

Опубликована: Фев. 28, 2025

The ubiquitin–proteasome system (UPS) and autophagy maintain protein homeostasis, which is critical to cellular function survival. dysregulation of these pathways has been recognized as a hallmark acute kidney injury chronic disease. This review elucidates the role UPS in disease, namely through inflammation, oxidative stress, fibrosis apoptosis. NF-κB, TGF-β mitochondrial failure result glomerular tubulointerstitial due impaired proteostasis podocytes tubular epithelial cells. Recent studies have revealed connection between autophagic process UPS, wherein compensatory mechanisms aim spike down proteotoxic stress but eventually seem inadequate cases derangement. Low-dose pharmacological inhibitors, modulators, new gene nanotechnology-based treatments may all help restore balance reduce injury. A more thorough understanding needed develop kidney-protective disease-modifying therapeutic interventions.

Язык: Английский

DECODING THE UMOD GENE: IMPLICATIONS FOR CHRONIC KIDNEY DISEASE THROUGH GENETIC MECHANISMS, DIAGNOSTICS, AND THERAPEUTIC INNOVATIONS DOI Creative Commons
Ташкенбаева Элеонора Негматовна, Mukhammad Esankulov

Medical science of Uzbekistan, Год журнала: 2025, Номер 1, С. 17 - 21

Опубликована: Фев. 25, 2025

This review examines recent advances in the study of UMOD genetic variations, their functional consequences, and impact on CKD pathogenesis. It also discusses potential clinical applications as a predictive biomarker for early detection, risk stratification, targeted interventions. The development transcriptomic, proteomic, metabolomic approaches allows more comprehensive function its interactions with other metabolic pathways. Chronic kidney disease (CKD) is growing global health concern, affecting millions people worldwide. Genetic factors play crucial role etiology progression CKD, influencing susceptibility, severity, treatment response. Among these factors, gene, which encodes glycoprotein uromodulin, recognized key regulator function, tubular integrity, susceptibility. polymorphisms affect by altering sodium transport, modulating immune responses, regulating oxidative stress, thereby contributing to hypertension, nephron damage, progression. Recent GWAS (genome-wide association studies) have confirmed between an increased related complications. Additionally, significant correlation has been identified hyperuricemia, uromodulin plays uric acid transport excretion. Conclusion: Personalized medicine based genotyping opens new opportunities individualized assessment, tailored pharmacotherapy, lifestyle modifications slow promising therapeutic strategies are being developed, including pharmacological modulation expression gene therapy.The integration knowledge highlights significance pathogenesis positions it target precision nephrology, potentially improving outcomes optimizing patient management strategies.

Язык: Английский

Процитировано

0
Renal Implications of Dysregulated Protein Homeostasis: Insights into Ubiquitin–Proteasome and Autophagy Systems DOI Creative Commons
Charlotte Delrue, Marijn M. Speeckaert

Biomolecules, Год журнала: 2025, Номер 15(3), С. 349 - 349

Опубликована: Фев. 28, 2025

The ubiquitin–proteasome system (UPS) and autophagy maintain protein homeostasis, which is critical to cellular function survival. dysregulation of these pathways has been recognized as a hallmark acute kidney injury chronic disease. This review elucidates the role UPS in disease, namely through inflammation, oxidative stress, fibrosis apoptosis. NF-κB, TGF-β mitochondrial failure result glomerular tubulointerstitial due impaired proteostasis podocytes tubular epithelial cells. Recent studies have revealed connection between autophagic process UPS, wherein compensatory mechanisms aim spike down proteotoxic stress but eventually seem inadequate cases derangement. Low-dose pharmacological inhibitors, modulators, new gene nanotechnology-based treatments may all help restore balance reduce injury. A more thorough understanding needed develop kidney-protective disease-modifying therapeutic interventions.

Язык: Английский

Процитировано

0