American Journal of Biomedical Science & Research, Год журнала: 2023, Номер 20(6), С. 861 - 868
Опубликована: Дек. 22, 2023
Glaucoma is a visual disorder that increasing in prevalence. While most cases of glaucoma world-wide present with an increased pressure the eye, majority open-angle China, Japan and Korea have normal Intraocular Pressure (IOP) are called Normal Tension (NTG).
Язык: Английский
World Journal of Virology, Год журнала: 2024, Номер 13(1)
Опубликована: Март 11, 2024
The aim of our minireview is to provide a brief overview the diagnosis, clinical aspects, treatment options, management, and current literature available regarding herpes simplex keratitis (HSK). This type corneal viral infection caused by virus (HSV), which can affect several tissues, including cornea. One significant aspect HSK its potential cause recurrent episodes inflammation damage After initial infection, HSV establish latent in trigeminal ganglion, nerve cluster near eye. may remain dormant for extended periods. Periodic reactivation occur, leading HSK. Factors triggering include stress, illness, immunosuppression, or trauma. Recurrent manifest different patterns, ranging from mild epithelial involvement more severe stromal endothelial disease. severity frequency recurrences vary among individuals. Severe cases HSK, especially those involving stroma scarring, result vision impairment even blindness extreme cases. cornea's clarity crucial good vision, scarring compromise this, potentially visual impairment. management involves not only treating acute but also implementing long-term strategies prevent attempt repairs endings via neurotization. Antiviral medications, such as oral Acyclovir topical Ganciclovir, be prescribed prophylaxis. immune response contribute damage. Inflammation, body's control inadvertently harm tissues. Clinicians should informed about triggers advised on measures minimize risk reactivation. In summary, nature underscores importance both preserve health maintain optimal function.
Язык: Английский
Процитировано
6
Pharmaceutics, Год журнала: 2025, Номер 17(1), С. 73 - 73
Опубликована: Янв. 7, 2025
Background/Objectives: Retinal ganglion cell (RGC) protection represents an unmet need in glaucoma. This study assessed the neuroprotective, antioxidant, and anti-inflammatory effect of a new nutraceutical formulation named Epicolin, based on citicoline, homotaurine, epigallocatechin-3-gallate, forskolin, vitamins, through vitro vivo studies. Methods: The neuroprotective Epicolin or its single components, compared to untreated control two marketed formulations [Formulation G (FG) N (FN)], was evaluated neuroblastoma cells (SH-SY5Y) challenged with staurosporine. antioxidant potential scavenging activity control, FG FN, SH-SY5Y oxygen radical absorbance capacity acellular assay, respectively. Moreover, protective against hypoxic damage Muller (MIO-M1) subjected hypoxia. efficacy also DBA/2J glaucomatous mice use pattern electroretinogram (PERG), immunostaining, real-time PCR. Results: Among tested, only showed significant attributable synergistic action ingredients. As for activity, higher FN. Furthermore, same MIO-M1 reducing HIF-1α expression. Finally, treatment protected RGCs from loss function, as demonstrated by PERG analysis, attenuated their death enhancing brain-derived neurotrophic factor (BDNF) interleukin-1 beta (IL-1β) tumor necrosis factor-alpha (TNF-α) Conclusions: due properties, promising
Язык: Английский
Процитировано
0
Molecular Aspects of Medicine, Год журнала: 2023, Номер 94, С. 101225 - 101225
Опубликована: Ноя. 24, 2023
Язык: Английский
Процитировано
9
Biomedicines, Год журнала: 2024, Номер 12(8), С. 1655 - 1655
Опубликована: Июль 25, 2024
Glaucoma is a major cause of incurable ocular morbidity and poses significant challenges in its management due to the limited treatment options potential adverse effects. Nicotinamide, naturally occurring diet-rich nutrient, has emerged as promising therapeutic agent for glaucoma, offering neuroprotective effects modulation intraocular pressure (IOP) regulation pathways. This comprehensive review sought analyze current literature on nicotinamide glaucoma management, exploring mechanisms action, efficacy, safety profile.
Язык: Английский
Процитировано
2
Frontiers in Bioscience-Landmark, Год журнала: 2024, Номер 29(8)
Опубликована: Авг. 23, 2024
This review explores the connection between ocular surface microbiome and glaucoma, highlighting its impact on disease progression. Beginning with an overview of global glaucoma significance, it emphasizes importance understanding cellular characteristics microbiology microbiome. A search was conducted PubMed Cochrane Library databases using phrase "ocular glaucoma". 0 records were returned from while 21 PubMed. total results retrieved 2017 to 2024. comprised one opinion paper, four original research articles, 16 reviews. covered anatomy surface, advanced analysis methods, It also delved into dysbiosis in addressing altered microbial communities their potential role The intricate interplay host's immune system is explored, emphasizing crosstalk inflammatory responses. concludes by discussing therapeutic implications, including modulating microbiota future treatment strategies. Understanding healthy glaucomatous eyes can help researchers clinicians innovative approaches health.
Язык: Английский
Процитировано
1
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Сен. 24, 2024
Язык: Английский
Процитировано
1
The journal of nutrition health & aging, Год журнала: 2024, Номер 28(8), С. 100286 - 100286
Опубликована: Июнь 12, 2024
To investigate the associations between circulating vitamins A, D, E, B6, B9, B12 and longitudinal changes in retinal nerve fiber layer (RNFL) thickness.
Язык: Английский
Процитировано
0
Опубликована: Май 17, 2024
Язык: Английский
Процитировано
0
Romanian Journal of Ophthalmology, Год журнала: 2024, Номер 68(3)
Опубликована: Окт. 7, 2024
Google and various social media platforms have content on the therapeutic potential of nutritional supplements for glaucoma, but whether that information is evidence-based has not been analyzed. The current study explores such its quality.
Язык: Английский
Процитировано
0
American Journal of Biomedical Science & Research, Год журнала: 2023, Номер 20(6), С. 861 - 868
Опубликована: Дек. 22, 2023
Glaucoma is a visual disorder that increasing in prevalence. While most cases of glaucoma world-wide present with an increased pressure the eye, majority open-angle China, Japan and Korea have normal Intraocular Pressure (IOP) are called Normal Tension (NTG).
Язык: Английский
Процитировано
1