Impacts of Matrix Metalloproteinase-2 Promoter Genotypes on Breast Cancer Risk
Cancer Genomics & Proteomics,
Год журнала:
2024,
Номер
21(5), С. 502 - 510
Опубликована: Авг. 27, 2024
Matrix
metalloproteinase-2
(MMP-2)
has
been
implicated
in
the
pathogenesis
of
breast
cancer
(BC).
However,
there
is
limited
research
on
role
MMP-2
genotypes
BC
risk.
This
study
aimed
to
investigate
associations
between
two
promoter
polymorphisms,
rs243865
and
rs2285053,
Язык: Английский
Association ofMatrix Metalloproteinase-9Genotypes With Nasopharyngeal Carcinoma Risk
In Vivo,
Год журнала:
2024,
Номер
38(4), С. 1731 - 1739
Опубликована: Янв. 1, 2024
Background/Aim:
The
up-regulation
of
matrix
metalloproteinase-9
(MMP-9)
expression
is
a
characteristic
feature
observed
across
various
malignancies,
including
nasopharyngeal
carcinoma
(NPC).
Nevertheless,
the
influence
MMP-9
genotype
in
context
NPC
remains
underexplored.
This
study
examined
implications
promoter
rs3918242
genotypes
on
susceptibility
to
Taiwan.
Materials
and
Methods:
In
cohort
comprising
208
cases
416
healthy
controls,
genotyping
was
conducted
utilizing
polymerase
chain
reaction-restriction
fragment
length
polymorphism
methodology.
Results:
Individuals
harbouring
variant
CT
or
TT
did
not
demonstrate
discernible
alteration
risk
when
compared
wild-type
CC
carriers
[odds
ratio
(OR)=0.83
0.79,
with
95%
confidence
intervals
(95%CI)=0.56-1.24
0.27-2.29;
p=0.4205
0.8675,
respectively].
Moreover,
presence
T
allele
confer
modified
(OR=0.84,
95%CI=0.60-1.19,
p=0.3761).
Intriguingly,
protective
effect
associated
against
discerned
among
individuals
abstaining
from
betel
quid
chewing
behaviour
(OR=0.51,
95%CI=0.30-0.87,
p=0.0166).
Notably,
no
significant
association
established
between
without
smoking
alcohol
consumption
habits.
Conclusion:
Presence
at
appear
substantially
contribute
an
elevated
NPC.
carrying
genotype,
particularly
those
chewing.
Язык: Английский
Impacts of Interleukin-10 Promoter Genotypes on Prostate Cancer
YU-TING CHIN,
Chung-Lin Tsai,
Hung-Huan Ma
и другие.
Life,
Год журнала:
2024,
Номер
14(8), С. 1035 - 1035
Опубликована: Авг. 20, 2024
Prostate
cancer
(PCa)
is
a
multifactorial
disease
influenced
by
genetic,
environmental,
and
immunological
factors.
Genetic
polymorphisms
in
the
Язык: Английский
Populist Protests and the Dynamic Zero-COVID Policy: (Re)emerging Pragmatic Populism in China
International Studies,
Год журнала:
2023,
Номер
60(3), С. 296 - 312
Опубликована: Июль 1, 2023
Populist
protests
in
the
People’s
Republic
of
China
(PRC)
have
recently
emerged
as
a
reaction
against
Chinese
authorities’
stringent
measures
under
its
dynamic
zero-COVID
policy.
Besides
vehement
criticism
and
policy,
during
some
protests,
there
been
ensuing
calls
across
country
for
President
Xi
Jinping
to
step
down.
The
article
argues
that
this
scenario
can
further
deteriorate
overall
political
legitimacy
Communist
Party
on
long-term
basis.
According
article,
indicate
re-emergence
populism
PRC,
which
incidentally
historically
has
parallels
at
Tiananmen
Square,
1919
May
Fourth
Movement.
theorizes
John
Dewey’s
concept
‘pragmatic
populism’
aspect
period,
inherently
provides
many
ideational
relational
facets
with
recent
China.
Язык: Английский