CHARACTERIZATION AND BIOSAFETY PROFILE OF EUGENOL INCORPORATED IN IRON OXIDE NANOPARTICLES DOI Creative Commons
Alexandra-Ioana Dănilă, Ştefania Dinu, Dániel Pop

и другие.

Опубликована: Сен. 15, 2024

Aim of the study Eugenol, a phenolic compound commonly found in plants like clove and bay leaves, has garnered significant attention field dentistry due to its diverse pharmacological properties. In dentistry, eugenol is frequently employed various forms, such as polymerized cement with zinc oxide for restorative purposes. Its applications extend endodontic cements oxide-eugenol formulations, which are used dental procedures. So far, according our knowledge, no literature approached formulations based on iron nanoparticles eugenol, this being first. Materials methods present study, it was developed first time formulation obtained through combustion method, embedded surface eugenol. The prepared characterized electron microscopy investigations, followed by further vitro evaluation concerned their biosafety use healthy murine epidermal cell line. Results results showed that naked biocompatible safe line, while exhibits dose-dependent cytotoxicity reaching until value ~17% at highest tested dose (100 μg/mL). addition, decreased when surface, recording 11% concentration tested. Conclusions conclusion, studies type medicine highlight multifaceted well emphasizing potential advancing treatments diagnostics.

Язык: Английский

CHARACTERIZATION AND BIOSAFETY PROFILE OF EUGENOL INCORPORATED IN IRON OXIDE NANOPARTICLES DOI Creative Commons
Alexandra-Ioana Dănilă, Ştefania Dinu, Dániel Pop

и другие.

Опубликована: Сен. 15, 2024

Aim of the study Eugenol, a phenolic compound commonly found in plants like clove and bay leaves, has garnered significant attention field dentistry due to its diverse pharmacological properties. In dentistry, eugenol is frequently employed various forms, such as polymerized cement with zinc oxide for restorative purposes. Its applications extend endodontic cements oxide-eugenol formulations, which are used dental procedures. So far, according our knowledge, no literature approached formulations based on iron nanoparticles eugenol, this being first. Materials methods present study, it was developed first time formulation obtained through combustion method, embedded surface eugenol. The prepared characterized electron microscopy investigations, followed by further vitro evaluation concerned their biosafety use healthy murine epidermal cell line. Results results showed that naked biocompatible safe line, while exhibits dose-dependent cytotoxicity reaching until value ~17% at highest tested dose (100 μg/mL). addition, decreased when surface, recording 11% concentration tested. Conclusions conclusion, studies type medicine highlight multifaceted well emphasizing potential advancing treatments diagnostics.

Язык: Английский

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