Cells, Год журнала: 2025, Номер 14(8), С. 564 - 564
Опубликована: Апрель 9, 2025
Cancer risk increases by 25 to 250% not only in dysmetabolic obese or overweight people with overt type 2 diabetes but also individuals intermediate hyperglycemia (pre-diabetes), especially pronounced of pancreatic hepatocellular cancer and obesity-related cancers, e.g., colorectal kidney bladder men, endometrial breast cancers women. may often be present before upon the diagnosis diabetes, as there is a common pathogenetic dysmetabolic–inflammatory background insulin resistance for developing cardiorenal disease, parallel. The mechanisms involved relate hyperinsulinemia potential carcinogenic priming event ectopic visceral, hepatic, pancreatic, renal fat accumulation that subsequently fuel inflammation lipo-oncogenic signals, causing mitochondrial oxidative stress deregulation. Moreover, foster mitogenic MAP kinase-related signaling, which can occur via IGF1 receptors due increased free levels obesity. Weight reduction 10% more pre-diabetes, through intensive lifestyle intervention bariatric (=metabolic) surgery treatment GLP-1 receptor agonists metformin, associated significantly lower incidence “diabesity”-associated cancers. In conclusion, seems huge utility adopting new “Cardio-Renal-Metabolic-Cancer Syndrome” approach, looking at time addition proactively screening undiagnosed dysglycemia.
Язык: Английский