Ceramics International, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
ACS Applied Bio Materials, Год журнала: 2024, Номер 7(5), С. 2660 - 2676
Опубликована: Май 9, 2024
Wound healing, particularly for chronic wounds, presents a considerable difficulty due to differences in biochemical and cellular processes that occur different types of wounds. Recent technological breakthroughs have notably advanced the understanding diagnostic therapeutic approaches wound healing. The evolution care has seen transition from traditional textile dressings variety alternatives, including self-healing hydrogels, hydrofibers, foams, hydrocolloids, environment responsive dressings, growth factor-based therapy, bioengineered skin substitutes, stem cell gene therapy. Technological advancements, such as 3D printing electronic (e-skin) contribute customization Despite these effectively managing wounds remains challenging. This necessitates development treatments consider performance, risk–benefit balance, cost-effectiveness. review discusses innovative strategies healing Incorporating biomarkers into coupled with corresponding biosensors drug delivery formulations, enables theranostic approach treatment Furthermore, integrating power sources user interfaces like near-field communication, radio frequency identification, Bluetooth enhances real-time monitoring on-demand delivery. It also provides thorough evaluation advantages, patient compliance, costs, durability emphasizing smart formulations their preparation methods.
Язык: Английский
Процитировано
19
Gels, Год журнала: 2025, Номер 11(1), С. 30 - 30
Опубликована: Янв. 2, 2025
This review summarizes the fundamental concepts, recent advancements, and emerging trends in field of stimuli-responsive hydrogels. While numerous reviews exist on this topic, continues to evolve dynamically, certain research directions are often overlooked. To address this, we classify hydrogels based their response mechanisms provide an in-depth discussion key properties mechanisms, including swelling kinetics, mechanical properties, biocompatibility/biodegradability. We then explore hydrogel design, synthesis, structural engineering, followed by overview applications that relatively well established from a scientific perspective, biomedical uses (biosensing, drug delivery, wound healing, tissue engineering), environmental (heavy metal phosphate removal environment polluted water), soft robotics actuation. Additionally, highlight unconventional such as local micro-thermometers cell mechanotransduction. concludes with current challenges future prospects field, aiming inspire further innovations advancements bring them closer societal needs.
Язык: Английский
Процитировано
6
Molecules, Год журнала: 2025, Номер 30(3), С. 686 - 686
Опубликована: Фев. 4, 2025
Chronic wounds pose a substantial healthcare concern due to their prevalence and cost burden. This paper presents detailed overview of chronic emphasizes the critical need for novel therapeutic solutions. The pathophysiology wound healing is discussed, including stages factors contributing chronicity. focus on diverse types wounds, such as diabetic foot necrosis, pressure ulcers, venous leg highlighting etiology, consequences, issues they provide. Further, modern care solutions, particularly hydrogels, are highlighted tackling challenges management. Hydrogels characterized multipurpose materials that possess vital characteristics like capacity retain moisture, biocompatibility, incorporation active drugs. Hydrogels’ effectiveness in applications demonstrated by how support healing, preserving ideal moisture levels, promoting cellular migration, possessing antibacterial properties. Thus, this hydrogel technology’s latest developments, emphasizing drug-loaded stimuli-responsive underscoring these advanced formulations greatly improve therapy outcomes enabling dynamic focused reactions environment. Future directions research promote development customized treatments digital health tools treatment wounds.
Язык: Английский
Процитировано
4
Advances in Colloid and Interface Science, Год журнала: 2024, Номер 332, С. 103278 - 103278
Опубликована: Авг. 14, 2024
Язык: Английский
Процитировано
11
International Journal of Pharmaceutics, Год журнала: 2024, Номер 656, С. 124099 - 124099
Опубликована: Апрель 16, 2024
Язык: Английский
Процитировано
10
Bioengineering & Translational Medicine, Год журнала: 2025, Номер unknown
Опубликована: Янв. 15, 2025
Abstract Previous studies of bladder tissue engineering simply seeded cells onto the surface material, which makes lack protection and it difficult to face complex in vivo environment. The gelatin methacryloyl (GelMA) hydrogel possesses outstanding biocompatibility distinctive photo‐crosslinking characteristics is capable offering a suitable three‐dimensional growth environment for cells. This study explored optimal concentration GelMA encapsulating adipose‐derived stem (ADSCs) combined with acellular matrix (BAM) create tissue‐engineered patch. Results indicated that 10% more effectively promoted ADSCs proliferation spreading compared 7.5% 12.5% concentrations, can offer better extracellular BAM performed as an excellent substrate mechanical properties stitchability similar natural tissues. Animal experiments demonstrated encapsulated enhanced patch vascularization BAM‐GelMA‐ADSCs repair large‐scale defects beagles promote regeneration functional recovery. photocrosslinking hydrogel‐acellular provides protective semi‐controlled ADSCs, supporting viability vivo, while being easy suture preventing leakage, has significant clinical potential.
Язык: Английский
Процитировано
0
Bone, Год журнала: 2025, Номер unknown, С. 117416 - 117416
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 304, С. 140961 - 140961
Опубликована: Фев. 12, 2025
Язык: Английский
Процитировано
0
Gels, Год журнала: 2025, Номер 11(4), С. 234 - 234
Опубликована: Март 23, 2025
Interest in developing new, effective materials for emergency hemostasis and wound healing is steadily increasing, particularly use emergency, surgical, military situations. Hydrogels, with their unique retention, swelling, biocompatibility properties, have emerged as essential therapy. This review provides a comprehensive examination of recent hydrogel applications acute medical scenarios, including hemostasis, management, drug delivery, soft tissue replacement, engineering. We discuss the physicochemical properties that make hydrogels suitable rapid response situations, such tunable mechanical strength, adhesiveness, responsiveness to environmental stimuli, ability encapsulate release therapeutic agents. Additionally, article explores advancements smart self-healing antimicrobial providing insights into potential revolutionize care increase survival rates both civilian applications. Through critical evaluation current clinical trials practical deployments, this highlights successes challenges faced integrating protocols, roadmap future research development dynamic field.
Язык: Английский
Процитировано
0
Cells, Год журнала: 2025, Номер 14(8), С. 566 - 566
Опубликована: Апрель 9, 2025
The numerous side effects and adverse health implications associated with chemotherapies have long plagued the field of cancer care. Whilst in some cases a curative measure, this highly toxic intervention consistently scores poorly on quantitative measures tolerability safety. Of these effects, cardiac microvascular defects pose greatest risk are leading cause death amongst survivors who do not succumb to relapse. In fact, many low-grade cancers, recurrence is far outweighed by cardiovascular morbidity. As such, there pressing need improve outcomes within populations. Polyphenols group naturally occurring metabolites that shown potential vasoprotective effects. Studies suggest they possess antioxidant anti-inflammatory activities, addition directly modulating vascular signalling pathways gene expression. Leveraging properties may help counteract toxicity induced chemotherapy. review, we outline main mechanisms which endothelium damaged chemotherapeutic agents discuss ability polyphenols such We future considerations overcome published limitations compounds stalled their clinical success. Finally, briefly explore pharmacological how novel approaches could enhance efficacy while minimising treatment-related
Язык: Английский
Процитировано
0