Antibacterial Properties of Dental Copolymer Modified with Monomers Possessing Quaternary Ammonium Groups DOI Creative Commons
Patryk Drejka, Marta W. Chrószcz-Porębska, Alicja Kazek‐Kęsik

и другие.

Опубликована: Ноя. 13, 2024

Dental caries are treated using dental composite restorative materials (DCRM). However, commercial DCRMs lack antibacterial activity. This research aimed to analyze the in vitro activity of a series copolymers consisting urethane–dimethacrylate monomer (UDMA), bisphenol A glycerolate dimethacrylate (Bis-GMA), triethylene glycol (TEGDMA) and with two quaternary ammonium groups 1,3-bis(1-isocyanate-1-methylethyl)benzene core (QAn+TMXDI, where n = 8, 10, or 12 is number carbon atoms N-alkyl substituent). QAn+TMXDI contents were 20 40 wt.%. The results Staphylococcus aureus Escherichia coli adhesion test demonstrated that logCFU/mL decreased as length chain content increased. QA8+TMXDI wt.%, Bis-GMA TEGDMA wt.% showed highest activity, 2.39 for S. no viable E. cells.

Язык: Английский

Novel Quaternary Ammonium Urethane-Dimethacrylates for Copolymers with Low Water Sorption and Solubility DOI Creative Commons
Patryk Drejka,

Patrycja Kula,

Izabela Barszczewska-Rybarek

и другие.

Molecules, Год журнала: 2025, Номер 30(4), С. 769 - 769

Опубликована: Фев. 7, 2025

Six novel urethane-dimethacrylates with quaternary ammonium groups (QAUDMAs) were successfully synthesized from 2-(methacryloyloxy)ethyl-2-hydroxyethylmethylalkylammonium bromide (QAHAMA-n, where n was 8 and 10) diisocyanate (isophorone (IPDI), 4,4'-methylenedicyclohexyl (CHMDI), 4,4'-diphenylmethane (MDI)). Their chemical structures confirmed through nuclear magnetic resonance spectroscopy (NMR) Fourier transform infrared (FTIR). The refractive index (RI) density (dm) also determined. QAUDMAs compounded common dental dimethacrylates subsequently photopolymerized. resulting copolymers, comprising QAUDMA 40 wt.%, bisphenol A glycerolate dimethacrylate (Bis-GMA) triethylene glycol (TEGDMA) 20 tested for water sorption (WS) solubility (SL). WS SL values decreased following these orderings based on the diisocyanate: IPDI > CHMDI MDI WS, SL. ranged 11.50 to 13.82 µg/mm3, significantly lower than recommended maximum materials, µg/mm3. that met maximum, 7.5 2.67 6.75 Only copolymer having QAHAMA-8- MDI-derived had slightly exceeding at 7.89

Язык: Английский

Процитировано

0
Synthesis and Structural Characterization of Novel Urethane-Dimethacrylate Monomers with Two Quaternary Ammonium Groups Based on Cycloaliphatic Diisocyanates DOI Creative Commons
Patryk Drejka,

Patrycja Kula,

Izabela Barszczewska-Rybarek

и другие.

Опубликована: Март 17, 2025

Diseases such are caries affect approximately 25% of the worldwide population. Such a state requires novel, antibacterial materials. This research aimed to synthesize and characterize structures two urethane-dimethacrylate monomers showing possible activity for dental composite restorative materials (DCRMs). The were based on isophorone diisocyanate (IPDI) dicyclohexylmethane 4,4′-diisocyanate (CHMDI). their key elements confirmed with application spectroscopy methods. Nuclear Magnetic Resonance Spectroscopy (1H 13C NMR) Fourier Transform Infrared (FTIR) applied. synthesized abovementioned techniques.

Язык: Английский

Процитировано

0
Antibacterial Properties of Dental Copolymer Modified with Monomers Possessing Quaternary Ammonium Groups DOI Creative Commons
Patryk Drejka, Marta W. Chrószcz-Porębska, Alicja Kazek‐Kęsik

и другие.

Опубликована: Ноя. 13, 2024

Dental caries are treated using dental composite restorative materials (DCRM). However, commercial DCRMs lack antibacterial activity. This research aimed to analyze the in vitro activity of a series copolymers consisting urethane–dimethacrylate monomer (UDMA), bisphenol A glycerolate dimethacrylate (Bis-GMA), triethylene glycol (TEGDMA) and with two quaternary ammonium groups 1,3-bis(1-isocyanate-1-methylethyl)benzene core (QAn+TMXDI, where n = 8, 10, or 12 is number carbon atoms N-alkyl substituent). QAn+TMXDI contents were 20 40 wt.%. The results Staphylococcus aureus Escherichia coli adhesion test demonstrated that logCFU/mL decreased as length chain content increased. QA8+TMXDI wt.%, Bis-GMA TEGDMA wt.% showed highest activity, 2.39 for S. no viable E. cells.

Язык: Английский

Процитировано

1