Super-Enhancers and Their Parts: From Prediction Efforts to Pathognomonic Status
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(6), С. 3103 - 3103
Опубликована: Март 7, 2024
Super-enhancers
(SEs)
are
regions
of
the
genome
that
play
a
crucial
regulatory
role
in
gene
expression
by
promoting
large-scale
transcriptional
responses
various
cell
types
and
tissues.
Recent
research
suggests
alterations
super-enhancer
activity
can
contribute
to
development
progression
disorders.
The
aim
this
is
explore
multifaceted
roles
super-enhancers
regulation
their
significant
implications
for
understanding
treating
complex
diseases.
Here,
we
study
summarise
classification
constituents,
possible
modes
interaction,
cross-regulation,
including
RNAs
(seRNAs).
We
try
investigate
opportunity
SE
dynamics
prediction
based
on
hierarchy
enhancer
single
elements
(enhancers)
aggregated
action.
To
further
our
understanding,
conducted
an
silico
experiment
compare
differentiate
between
locus-control
(LCRs),
shedding
light
enigmatic
relationship
LCRs
SEs
within
human
genome.
Particular
attention
paid
specific
mechanisms
diversity,
exemplified
oncological,
cardiovascular,
immunological
diseases,
as
well
overview
several
anti-SE
therapies.
Overall,
work
presents
comprehensive
analysis
across
different
aiming
provide
insights
into
may
act
rationale
future
clinical
interventions
targeting
these
elements.
Язык: Английский
Stannous Chloride-Modified Glass Substrates for Biomolecule Immobilization: Development of Label-Free Interferometric Sensor Chips for Highly Sensitive Detection of Aflatoxin B1 in Corn
Biosensors,
Год журнала:
2024,
Номер
14(11), С. 531 - 531
Опубликована: Ноя. 3, 2024
This
study
presents
the
development
of
stannous
chloride
(SnCl
Язык: Английский