Hydrogels for Peripheral Nerve Repair: Emerging Materials and Therapeutic Applications
Gels,
Год журнала:
2025,
Номер
11(2), С. 126 - 126
Опубликована: Фев. 9, 2025
Peripheral
nerve
injuries
pose
a
significant
clinical
challenge
due
to
the
complex
biological
processes
involved
in
repair
and
their
limited
regenerative
capacity.
Despite
advances
surgical
techniques,
conventional
treatments,
such
as
autografts,
are
faced
with
limitations
like
donor
site
morbidity
inconsistent
functional
outcomes.
As
such,
there
is
growing
interest
new,
novel,
innovative
strategies
enhance
regeneration.
Tissue
engineering/regenerative
medicine
its
use
of
biomaterials
an
emerging
example
strategy.
Within
realm
tissue
engineering,
functionalized
hydrogels
have
gained
considerable
attention
ability
mimic
extracellular
matrix,
support
cell
growth
differentiation,
even
deliver
bioactive
molecules
that
can
promote
repair.
These
be
engineered
incorporate
factors,
peptides,
stem
cells,
creating
conducive
microenvironment
for
cellular
axonal
Recent
advancements
materials
well
biology
led
development
sophisticated
hydrogel
systems,
not
only
provide
structural
support,
but
also
actively
modulate
inflammation,
recruitment,
stimulate
neurogenesis.
This
review
explores
potential
peripheral
repair,
highlighting
composition,
biofunctionalization,
mechanisms
action.
A
comprehensive
analysis
preclinical
studies
provides
insights
into
efficacy
these
promoting
growth,
neuronal
survival,
regeneration,
and,
ultimately,
recovery.
Thus,
this
aims
illuminate
promise
transformative
tool
field
bridging
gap
between
complexity
feasibility.
Язык: Английский
Hydrogel-Based Innovations in Carpal Tunnel Syndrome: Bridging Pathophysiological Complexities and Translational Therapeutic Gaps
Gels,
Год журнала:
2025,
Номер
11(1), С. 52 - 52
Опубликована: Янв. 9, 2025
Carpal
Tunnel
Syndrome
(CTS)
is
a
prevalent
neuropathic
disorder
caused
by
chronic
compression
of
the
median
nerve,
leading
to
sensory
and
motor
impairments.
Conventional
treatments,
such
as
corticosteroid
injections,
wrist
splinting,
surgical
decompression,
often
fail
provide
adequate
outcomes
for
or
recurrent
cases,
emphasizing
need
innovative
therapies.
Hydrogels,
highly
biocompatible
three-dimensional
biomaterials
with
customizable
properties,
hold
significant
potential
CTS
management.
Their
ability
mimic
extracellular
matrix
facilitates
localized
drug
delivery,
anti-adhesion
barrier
formation,
tissue
regeneration.
Advances
in
hydrogel
engineering
have
introduced
stimuli-responsive
systems
tailored
biomechanical
environment
carpal
tunnel,
enabling
sustained
therapeutic
release
improved
integration.
Despite
these
promising
developments,
applications
remain
underexplored.
Key
challenges
include
absence
CTS-specific
preclinical
models
rigorous
clinical
validation.
Addressing
gaps
could
unlock
full
hydrogel-based
interventions,
which
offer
minimally
invasive,
solutions
that
improve
long-term
reduce
recurrence
rates.
This
review
highlights
hydrogels
transformative
approach
therapy,
advocating
continued
research
address
translational
barriers.
These
innovations
redefine
treatment
landscape,
significantly
enhancing
patient
care
quality
life.
Язык: Английский
Cyclodextrin–Hydrogel Hybrids in Advanced Drug Delivery
Gels,
Год журнала:
2025,
Номер
11(3), С. 177 - 177
Опубликована: Фев. 28, 2025
Cyclodextrin
(CD)–hydrogel
hybrids
have
emerged
as
versatile
and
multifunctional
drug
delivery
systems,
offering
enhanced
solubility,
controlled
release,
improved
bioavailability.
By
combining
the
inclusion
complexation
properties
of
CDs
with
swelling
retention
capabilities
hydrogels,
these
hybrid
systems
overcome
key
challenges
in
conventional
formulations.
This
review
explores
CD
composition,
hydrogel
polymer
selection,
fabrication
techniques,
release
factors,
real-world
therapeutic
applications.
Additionally,
latest
advancements
stimuli-responsive
nanogels,
microneedle-based
are
discussed.
While
CD–hydrogel
demonstrate
significant
potential,
scalability,
regulatory
hurdles,
clinical
translation
remain
challenges.
Future
research
should
focus
on
smart
loading
strategies,
validation
to
bridge
gap
between
laboratory
innovations
commercial
Язык: Английский
Research and application of conductive nanofiber nerve guidance conduits for peripheral nerve regeneration: a narrative review
Advanced technology in neuroscience .,
Год журнала:
2025,
Номер
2(1), С. 47 - 57
Опубликована: Фев. 6, 2025
Autologous
nerve
grafting
has
long
been
considered
the
gold
standard
treatment
for
repairing
peripheral
injury.
However,
it
faces
challenges
such
as
limited
availability
of
donor
nerves
and
complications
at
site.
As
a
result,
there
an
ongoing
shift
toward
use
novel
biomaterials.
Conductive
nanofiber
guidance
conduits
appear
to
be
optimal
solution
due
their
excellent
mechanical
stability,
structure,
electrical
stimulation
properties,
which
can
help
restore
original
neural
microenvironment.
This
review
article
focuses
on
in-depth
investigation
breakthroughs
in
conductive
regeneration.
It
summarizes
various
materials
that
have
used
development
conduits,
including
carbon
nanofibers,
multiwalled
nanotubes,
reduced
graphene
oxide,
nanoparticles,
polymers
polypyrrole,
polyaniline,
polydioxothiophene.
Furthermore,
this
also
addresses
contributions
manufacturing
strategies,
hybrid
electrospinning
surface
coating,
electrical,
mechanical,
biological
properties
conduits.
covers
practical
applications
these
improving
cell
function
facilitating
tissue
repair.
Although
application
prospects
are
promising,
remain
controlling
ensure
biocompatibility.
Future
research
will
focus
addressing
limitations
optimize
therapeutic
technology,
ultimately
providing
better
outcomes
patients
with
Язык: Английский
The Art of Neuroregeneration De Novo and In Situ
Advances in experimental medicine and biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Smart Self-Assembled Peptide-based Hydrogels: Mechanism, Design and Biomedical Applications
Colloids and Surfaces B Biointerfaces,
Год журнала:
2025,
Номер
unknown, С. 114704 - 114704
Опубликована: Апрель 1, 2025
Язык: Английский
Chemical materials involved in neural tissue engineering scaffold techniques: a narrative review
Advanced technology in neuroscience .,
Год журнала:
2024,
Номер
1(2), С. 244 - 260
Опубликована: Ноя. 27, 2024
Nerve
injury
often
leads
to
degeneration
or
necrosis
of
damaged
nerve
cells,
which
can
result
in
regeneration
disorders
during
the
repair
process.
Promoting
is
a
critical
challenge
treatment
nervous
system
diseases.
With
rapid
advancements
related
research,
chemical
materials
have
shown
significant
promise
facilitating
because
their
excellent
biocompatibility
and
degradability.
The
use
tissue-engineered
material
scaffolds
provide
physical
channels
for
regeneration.
These
create
optimal
conditions
cell
growth
migration
effectively
regulate
physiological
processes
repair.
Therefore,
wide
range
applications
field
This
review
highlights
technological
tools
available
involving
materials.
(1)
Conductive
hydrogels:
Novel
conductive
hydrogels
been
developed
by
integrating
such
as
graphene,
carbon
nanotubes,
polypyrrole,
promote
functional
recovery
cells
through
electrical
stimulation.
(2)
Three-dimensional
printing:
printing
technology
contributes
precise
control
shape,
porosity
degradation
rate
scaffolds,
providing
customized
microenvironment
(3)
Nanomaterials:
unique
physicochemical
properties
nanoparticles
nanofibers
give
them
great
potential
penetrate
blood‒brain
barrier,
guide
targeted
drug
delivery.
(4)
Local
release
bioactive
molecules:
Through
design
materials,
controlled
molecules
factor,
brain-derived
neurotrophic
factor
fibroblast
has
realized,
promotes
(5)
Photothermal
photoacoustic
stimulation:
combination
photothermal
technologies
led
development
capable
responding
photostimulation,
new
avenues
noninvasive
neurostimulation.
engineering
are
highly
effective
promoting
significantly
improve
efficiency
quality
In
clinical
practice,
these
techniques
expected
more
strategies
patients
with
injuries,
improving
function
life.
also
discusses
detail
different
biocompatibility,
mechanical
strength,
degradability,
A
variety
neural
tissue
scaffold
techniques,
including
provision
support,
molecules,
direct
interaction
cells.
Although
show
potential,
several
challenges,
long-term
stability,
individual
variation
response,
large-scale
production,
still
need
be
addressed
before
they
translated
into
applications.
addition,
comprehensive
assessment
safety
efficacy
focus
future
research.
Future
research
will
on
optimizing
conducting
trials
validate
techniques.
Язык: Английский