Bioactive Peptides Derived from Seaweed Protein and Their Health Benefits: Antihypertensive, Antioxidant, and Antidiabetic Properties

Journal of Food Science, Год журнала: 2017, Номер 83(1), С. 6 - 16

Опубликована: Дек. 11, 2017

Abstract Cardiovascular diseases and diabetes are the biggest causes of death globally. Therefore, prevention these is a focus pharmaceuticals functional food manufacturers. This review summarizes recent research trends scientific knowledge in seaweed protein‐derived peptides with particular emphasis on production, isolation potential health impacts hypertension, oxidative stress. The current status future prospects bioactive also discussed. Bioactive have strong for use therapeutic drug formulation management strategy, especially cardiovascular disease diabetes. Seaweeds can be used as sustainable protein sources production peptide‐based drugs foods preventing such diseases. Many studies reported that showing angiotensin converting enzyme inhibition, antihypertensive, antioxidative antidiabetics activities, been successfully isolated from seaweed. However, further needed large‐scale peptides, efficient methods, interactions other pharmaceuticals, their ease to digestion vivo safety validate benefits peptides.

Язык: Английский

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Marine Fish Proteins and Peptides for Cosmeceuticals: A Review

Marine Drugs, Год журнала: 2017, Номер 15(5), С. 143 - 143

Опубликована: Май 18, 2017

Marine fish provide a rich source of bioactive compounds such as proteins and peptides. The peptides derived from marine have gained enormous interest in nutraceutical, pharmaceutical, cosmeceutical industries due to their broad spectrum bioactivities, including antioxidant, antimicrobial, anti-aging activities. Recently, the development cosmeceuticals using fish-derived obtained chemical or enzymatical hydrolysis processing by-products has increased rapidly owing activities antioxidation tissue regeneration. collagen been utilized for products its abilities skin repair also various applications matrix metalloproteinase inhibitory In addition, hydrolysates demonstrated efficient anti-photoaging activity. present review highlights presents an overview current status isolation This demonstrates that high potential biocompatible effective cosmeceuticals.

Язык: Английский

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The versatility of collagen and chitosan: From food to biomedical applications

Food Hydrocolloids, Год журнала: 2021, Номер 116, С. 106633 - 106633

Опубликована: Янв. 28, 2021

Biodegradable polymers obtained from renewable resources, such as chitosan and collagen, are sustainable alternatives to develop environmentally friendly materials. Due their abundance, biocompatibility antimicrobial properties, collagen could become a suitable source for food biomedical applications. In particular, formulations used packaging purposes intelligent with the aim of providing information about quality packaged product or prepare active extend shelf life. this regard, nanoparticles can be provide sustained release substances. Regarding denatured gelatin is prevalently in industry additive, microencapsulating agent biodegradable material due its rheological properties physical versatility. turn, collagen-derived peptides have revealed antioxidant antihypertensive activity, among other health beneficial effects cosmetic nutraceutical Additionally, widely tissue engineering, also combined chitosan, achieve functional required specific applications field. sense, collagen/chitosan scaffolds been bone, cartilage skin regeneration. This research design processing materials based on proteins polysaccharides leading great advances fields.

Язык: Английский

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Recently isolated antidiabetic hydrolysates and peptides from multiple food sources: a review

Critical Reviews in Food Science and Nutrition, Год журнала: 2018, Номер 60(2), С. 322 - 340

Опубликована: Ноя. 21, 2018

Diabetes, a metabolic syndrome of global importance has been on progressive rise in recent years. Several pharmacological approaches have made, which proved effective, but with underlying side effects. Bioactive hydrolysates (BHs) and peptides (BPs) from food sources, however, shown the relative advantage imparting less adverse Furthermore, BHs BPs discovered to impart their antidiabetic potentials through one or more mechanisms such as inhibition digestive enzymes, antigenic enzyme – Dipeptyl peptidase IV (DPP-IV), decrease blood glucose levels increase insulin uptake. plants animal sources used protein for isolation different analytical techniques. This review integrates research information about several popular unconventional BPs, techniques, effects profiles. In addition, fractionation technique(s) employed each study are reviewed. article is intended supplement accessible scholarly literature intellectual awareness subject food-oriented approach management diabetes.

Язык: Английский

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Biotechnological Applications of Microalgal Oleaginous Compounds: Current Trends on Microalgal Bioprocessing of Products

Frontiers in Energy Research, Год журнала: 2020, Номер 8

Опубликована: Дек. 17, 2020

The microalgal biotechnology industry is expanding rapidly and currently gaining attention due to multiple availabilities of high-value products such as pigments, carbohydrates, proteins, nutraceuticals, biopharmaceuticals, unique oleaginous compounds fractionated by biomass biorefinery. Microalgae are efficient primary producers in the terrestrial marine biotopes. They major sources global oxygen topical prominence their concomitant role phycoremediation wastewater effluents production. Despite minuscule size, microalgae critically contribute climate change mitigation through carbon fixation play a bioenergy applications. Furthermore, carotenoids phycobiliproteins main accessory light-harvesting complexes cyanobacteria. biomedical pharmaceutical applications include anticancer, antidiabetic, antiHIV, antimalarial, antimicrobial, inter alia . endowment indigenous utilization these biological resources must be harnessed biorefinery exploit opportunities. Therefore, this manuscript factually explores current status approach, applications, biofuel genetic manipulation for enhancement product yield, challenges presents prospects, pros cons, outlook industry.

Язык: Английский

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Glycosaminoglycan from Apostichopus japonicus Improves Glucose Metabolism in the Liver of Insulin Resistant Mice

Marine Drugs, Год журнала: 2019, Номер 18(1), С. 1 - 1

Опубликована: Дек. 18, 2019

Holothurian glycosaminoglycan isolated from Apostichopus japonicus (named AHG) can suppress hepatic glucose production in insulin resistant hepatocytes, but its effects on metabolism vivo are unknown. The present study was conducted to investigate the of AHG hyperglycemia liver mice induced by a high-fat diet (HFD) for 12 weeks. results demonstrated that supplementation apparently reduced body weight, blood level, and serum content dose-dependent manner HFD-fed mice. protein levels gene expression gluconeogenesis rate-limiting enzymes G6Pase PEPCK were remarkedly suppressed liver. In addition, although total IRS1, Akt, AMPK not affected supplementation, phosphorylation clearly elevated treatment. These suggest could be promising natural marine product development an antihyperglycemic agent.

Язык: Английский

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Bioactive peptides with antidiabetic properties: a review

International Journal of Food Science & Technology, Год журнала: 2019, Номер 54(6), С. 1909 - 1919

Опубликована: Фев. 17, 2019

Abstract Diabetes mellitus is a complex disorder characterised by insufficient insulin production or resistance. Disease incidence accumulating at rapidly increasing rate, resulting in considerable social, health and economic burden the modern world. Bioactive peptides show significant potential for use management strategies, particularly as components of drugs functional foods diabetes treatment. Many antidiabetic bioactive have been isolated validated. The aim this review was to update state knowledge origin, structural characteristics action. Additionally, mechanisms on key enzymes proteins, such α‐amylase, α‐glucosidase, glucagon‐like dipeptidyl peptidase‐IV, that participate glycaemic level control from intake carbohydrates blood glucose regulation were overviewed. This should facilitate research industrial efforts better understand evaluate with properties management.

Язык: Английский

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Pheophorbide a: State of the Art

Marine Drugs, Год журнала: 2020, Номер 18(5), С. 257 - 257

Опубликована: Май 14, 2020

Chlorophyll breakdown products are usually studied for their antioxidant and anti-inflammatory activities. The chlorophyll derivative Pheophorbide a (PPBa) is photosensitizer that can induce significant anti-proliferative effects in several human cancer cell lines. Cancer leading cause of death worldwide, accounting about 9.6 million deaths, 2018 alone. Hence, it crucial to monitor emergent compounds show anticancer activity advance them into clinical trials. In this review, we analyze the PPBa with or without photodynamic therapy also conjugated other chemotherapic drugs, highlighting capacity overcome multidrug resistance. We report activities different pathways activate, showing its possible applications treatment pathologies.

Язык: Английский

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Biotechnological Applications of Bioactive Peptides From Marine Sources

Advances in microbial physiology/Advances in Microbial Physiology, Год журнала: 2018, Номер unknown, С. 171 - 220

Опубликована: Янв. 1, 2018

Язык: Английский

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Unlocking the Health Potential of Microalgae as Sustainable Sources of Bioactive Compounds

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(9), С. 4383 - 4383

Опубликована: Апрель 22, 2021

Microalgae are known to produce a plethora of compounds derived from the primary and secondary metabolism. Different studies have shown that these may allelopathic, antimicrobial, antipredator activities. In addition, in vitro vivo screenings several interesting bioactivities (such as antioxidant, anti-inflammatory, anticancer, antimicrobial) for possible prevention treatment human pathologies. Additionally, enzymatic pathways responsible synthesis compounds, targets mechanisms their action also been investigated few species. However, further research is necessary full exploitation pharmaceutical other industrial applications. Here, we review current knowledge on chemical characteristics, biological activities, mechanism action, enzymes involved microalgal metabolites with potential benefits health.

Язык: Английский

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