Molecules,
Год журнала:
2023,
Номер
28(19), С. 6918 - 6918
Опубликована: Окт. 3, 2023
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
syndrome.
The
prevalence
of
NAFLD
has
continued
to
increase
globally,
and
become
worldwide
public
health
problem.
Glucosamine
(GLC)
an
amino
monosaccharide
derivative
glucose.
GLC
been
proven
not
only
be
effective
in
anti-inflammation
applications,
but
also
modulate
the
gut
microbiota
effectively.
Therefore,
this
study,
therapeutic
effect
context
mechanisms
underlying
these
effects
were
explored.
Specifically,
model
was
established
by
feeding
mice
high-fat
high-sugar
diet
(HFHSD),
HFHSD-fed
treated
with
GLC.
First,
we
investigated
treating
analyzing
serum-
liver-related
indicator
levels.
We
found
that
attenuated
insulin
resistance
inflammation,
increased
antioxidant
function,
serum
lipid
metabolism
mice.
Then,
mechanism
metabolism,
intestinal
barrier
function
can
improve
relieve
oxidative
stress
In
addition,
treatment
reduced
LPS
translocation,
inflammation
inhibiting
activation
LPS/TLR4/NF-κB
pathway,
thereby
effectively
ameliorating
lesions
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
164, С. 114985 - 114985
Опубликована: Июнь 11, 2023
The
gut
microbiota
is
indispensable
for
maintaining
host
health
by
enhancing
the
host's
digestive
capacity,
safeguarding
intestinal
epithelial
barrier,
and
preventing
pathogen
invasion.
Additionally,
exhibits
a
bidirectional
interaction
with
immune
system
promotes
of
to
mature.
Dysbiosis
microbiota,
primarily
caused
factors
such
as
genetic
susceptibility,
age,
BMI,
diet,
drug
abuse,
significant
contributor
inflammatory
diseases.
However,
mechanisms
underlying
diseases
resulting
from
dysbiosis
lack
systematic
categorization.
In
this
study,
we
summarize
normal
physiological
functions
symbiotic
in
healthy
state
demonstrate
that
when
occurs
due
various
external
factors,
are
lost,
leading
pathological
damage
lining,
metabolic
disorders,
barrier
damage.
This,
turn,
triggers
disorders
eventually
causes
systems.
These
discoveries
provide
fresh
perspectives
on
how
diagnose
treat
unrecognized
variables
might
affect
link
between
illnesses
need
further
studies
extensive
basic
clinical
research
will
still
be
required
investigate
relationship
future.
Marine Drugs,
Год журнала:
2023,
Номер
21(3), С. 147 - 147
Опубликована: Фев. 24, 2023
Chitosan
is
a
marine-origin
polysaccharide
obtained
from
the
deacetylation
of
chitin,
main
component
crustaceans'
exoskeleton,
and
second
most
abundant
in
nature.
Although
this
biopolymer
has
received
limited
attention
for
several
decades
right
after
its
discovery,
since
new
millennium
chitosan
emerged
owing
to
physicochemical,
structural
biological
properties,
multifunctionalities
applications
sectors.
This
review
aims
at
providing
an
overview
chemical
functionalization,
innovative
biomaterials
thereof.
Firstly,
functionalization
backbone
amino
hydroxyl
groups
will
be
addressed.
Then,
focus
on
bottom-up
strategies
process
wide
array
chitosan-based
biomaterials.
In
particular,
preparation
hydrogels,
organic-inorganic
hybrids,
layer-by-layer
assemblies,
(bio)inks
their
use
biomedical
field
covered
aiming
elucidate
inspire
community
keep
exploring
unique
features
properties
imparted
by
develop
advanced
devices.
Given
body
literature
that
appeared
past
years,
far
being
exhaustive.
Selected
works
last
10
years
considered.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2022,
Номер
10
Опубликована: Май 2, 2022
Chitosan
and
its
derivatives
are
bioactive
molecules
that
have
recently
been
used
in
various
fields,
especially
the
medical
field.
The
antibacterial,
antitumor,
immunomodulatory
properties
of
chitosan
extensively
studied.
can
be
as
a
drug-delivery
carrier
form
hydrogels,
sponges,
microspheres,
nanoparticles,
thin
films
to
treat
diseases,
those
skin
soft
tissue
such
injuries
lesions
skin,
muscles,
blood
vessels,
nerves.
prevent
also
diseases
by
exerting
diverse
biological
effects
antioxidant,
regeneration
effects.
Owing
antitumor
properties,
targeted
therapy
tumors.
Moreover,
owing
antibacterial
antioxidant
prevention
treatment
infections.
stop
bleeding
open
wounds
promoting
platelet
agglutination.
It
promote
tissues
Drug-delivery
carriers
containing
wound
dressings
healing.
This
review
summarizes
structure
characteristics
derivatives.
recent
breakthroughs
future
trends
therapeutic
drug
delivery
functions
including
anti-infection,
promotion
healing,
anticancer
on
elaborated.
Coatings,
Год журнала:
2022,
Номер
12(10), С. 1469 - 1469
Опубликована: Окт. 5, 2022
In
recent
years,
biomedical
materials
have
been
used
in
the
response
to
emergence
of
medical
infections
that
pose
a
serious
threat
health
and
life
patients.
The
construction
superhydrophobic
coatings
antimicrobial
is
among
most
effective
strategies
address
this
type
derived
infection.
Firstly,
paper
reviews
preparation
methods
surface
their
applications;
summarizes
advantages
disadvantages
schemes
based
on
template
method,
spraying
methods,
etching
respective
improvement
measures;
focuses
applications
surfaces
self-cleaning
antibacterial
coatings.
Then,
action
mechanisms
contact
coatings,
anti-adhesion
bacteriostatic
bactericidal
intelligent
are
introduced,
characteristics,
advantages,
summarized.
application
potential
field
highlighted.
Finally,
devices
discussed
detail,
reasons
for
current
difficulties
commercial
analyzed,
future
directions
considered.
