Theoretical Chemistry Accounts, Год журнала: 2023, Номер 142(9)
Опубликована: Авг. 21, 2023
Язык: Английский
Tetrahedron, Год журнала: 2025, Номер unknown, С. 134760 - 134760
Опубликована: Июнь 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Microbiology, Год журнала: 2023, Номер 14
Опубликована: Окт. 2, 2023
Cyclodepsipeptides are a large family of peptide-related natural products consisting hydroxy and amino acids linked by amide ester bonds. A number cyclodepsipeptides have been isolated characterized from fungi bacteria. Most them showed antitumor, antifungal, antiviral, antimalarial, antitrypanosomal properties. Herein, this review summarizes the recent literatures (2010-2022) on progress bacteria except for those marine origin, in order to enrich our knowledge about their structural features biological sources.
Язык: Английский
Процитировано
6
Опубликована: Май 15, 2024
A modular, atroposelective total synthesis of micitide 982 (1) is reported. The feature this report the gram-scale C-H biarylation N-phthaloyl-L-alanine followed by Larock macrocyclization. This modular approach allowed construction a highly strained atrop-Tyr-Trp cross-linkage with unprecedented atropisomerism, as well first (1).
Язык: Английский
Процитировано
2
Marine Drugs, Год журнала: 2023, Номер 21(10), С. 547 - 547
Опубликована: Окт. 22, 2023
In the post-antibiotic era, rapid development of antibiotic resistance and shortage available antibiotics are triggering a new health-care crisis. The discovery novel potent to extend pipeline is urgent. Small-molecule antimicrobial peptides have wide variety spectra multiple innovative mechanisms due their rich structural diversity. Consequently, they become research hotspot considered be promising candidates for next-generation antibiotics. Therefore, we compiled collection small-molecule derived from marine microorganisms last fifteen years show recent advances in this field. We categorize these compounds into three classes—cyclic oligopeptides, cyclic depsipeptides, lipopeptides—according features, present sources, structures, spectrums, with discussion structure activity relationships action some compounds.
Язык: Английский
Процитировано
5
Organic Letters, Год журнала: 2024, Номер 26(15), С. 3284 - 3288
Опубликована: Март 28, 2024
This work reports the first solvent-free catalytic approach for cleavage of fluorenylmethoxycarbonyl (Fmoc) protecting group from amine and alcohol functionalities. Various saccharide, peptide, glyco-amino acid substrates were efficiently deprotected by simple treatment with 20 mol % neat 4-dimethylaminopyridine (DMAP) (one effective base catalysts found), without any solvent or stoichiometric additives. Small model structures finally assembled through one-pot, base-catalyzed, multistep sequences combining Fmoc esterification, amidation, and/or glycosylation steps.
Язык: Английский
Процитировано
1
Phytochemistry Reviews, Год журнала: 2024, Номер unknown
Опубликована: Апрель 22, 2024
Язык: Английский
Процитировано
1
Angewandte Chemie International Edition, Год журнала: 2024, Номер unknown
Опубликована: Июль 15, 2024
Abstract We report the development of a novel synthetic approach for highly strained atrop‐Tyr C‐6‐to‐Trp N‐1′ linkage, which can be executed on decagram scale using modular strategy involving palladium‐catalyzed C−H arylation followed by Larock macrocyclization. The first total synthesis lapparbin ( 1 ) was achieved applying this strategy. Furthermore, utilizing and macrocyclization, discovered in ), demonstrated to applicable various arbitrary biaryl linkages, including non‐natural types.
Язык: Английский
Процитировано
1
Chinese Journal of Chemistry, Год журнала: 2024, Номер 42(23), С. 3023 - 3028
Опубликована: Авг. 21, 2024
Comprehensive Summary The first total synthesis of neopetromin, featuring the highly strained Tyr C‐6‐to‐Trp N‐1’ linkage, is hereby reported. This modular synthetic strategy, employing C—H arylation and Larock macrocyclization, offers a novel approach to various RiPPs natural product families.
Язык: Английский
Процитировано
1
Biomolecules, Год журнала: 2024, Номер 14(10), С. 1244 - 1244
Опубликована: Окт. 1, 2024
sp. G2112, an isolate from cucumber plants that inhibited plant pathogens, produces not only surfactins, iturins, and fengycins common to many
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12601 - 12601
Опубликована: Ноя. 23, 2024
Marine-derived peptides display potent antihypertensive, antioxidant, analgesic and antimicrobial biological effects. Some of them have also been found to anticancer activity via various mechanisms differing from those continental organisms. This diversity properties-together with the peptides' efficacy, which has confirmed in several vitro vivo studies-make these compounds attractive as functional ingredients pharmacy, especially regard multitarget drugs known hybrids. Given possibilities offered by chimeric structures, it is expected that a hybridization strategy based on marine-derived compound could result long-awaited success development new effective combat range complex diseases. However, despite fact such hybrids may exceed their parent compounds, there still an urgent need carefully determine potential off-targets thus possible clinically important side above, aim this paper provide information marine origin peptide structures verify occurrence usage hybrid built structures. Furthermore, authors believe presented here will serve increase public awareness opportunities arising combination strategies molecules properties, thereby accelerating drug candidates.
Язык: Английский
Процитировано
1