Marine natural products
Natural Product Reports,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
comprehensive
review
of
1220
new
MNPs
including
a
novel
sex
inducing
pheromone
from
the
diatom
Seminavis
robusta
.
Язык: Английский
Novel Bioactive Natural Products from Marine-Derived Penicillium Fungi: A Review (2021–2023)
Marine Drugs,
Год журнала:
2024,
Номер
22(5), С. 191 - 191
Опубликована: Апрель 23, 2024
Marine-derived
Язык: Английский
Genome Mining of a Deep-Sea-Derived Penicillium allii-sativi Revealed Polyketide-Terpenoid Hybrids with Antiosteoporosis Activity
Organic Letters,
Год журнала:
2024,
Номер
26(18), С. 3889 - 3895
Опубликована: Апрель 26, 2024
Two
novel
meroterpenoids,
alliisativins
A
and
B
(1,
2)
were
discovered
through
a
genome-based
exploration
of
the
biosynthetic
gene
clusters
deep-sea-derived
fungus
Penicillium
allii-sativi
MCCC
entry
3A00580.
Extensive
spectroscopic
analysis,
quantum
calculations,
chemical
derivatization,
biogenetic
considerations
utilized
to
establish
their
structures.
Alliisativins
possess
unique
carbon
skeleton
featuring
drimane
sesquiterpene
with
highly
oxidized
polyketide.
Noteworthily,
alliisativin
(1)
showed
dual
activity
in
promoting
osteogenesis
inhibiting
osteoclast,
indicating
an
antiosteoporosis
potential.
Язык: Английский
Viridicatol from the Deep‐Sea‐Derived Fungus Alleviates Bone Loss by Targeting the Wnt/SHN3 Pathway
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 7, 2025
Abstract
As
an
enticing
bone
anabolic
target,
short‐term
inhibition
of
Schnurri‐3
(SHN3)
resulted
in
high‐bone
mass
due
to
augmented
osteoblast
activity.
However,
no
studies
are
conducted
identify
natural
products
targeting
SHN3
inhibition.
Herein,
a
screening
strategy
for
the
discovery
marine
compounds
that
facilitate
differentiation
by
silencing
is
presented.
One
leading
quinolinone
alkaloid,
viridicatol
(VDC),
isolated
from
deep‐sea‐derived
fungus,
vigorously
promotes
osteogenic
via
Wnt/SHN3
signaling
pathway
osteoblasts,
thereby
preventing
osteoporosis
while
enhancing
bone‐fracture
healing
mouse
model.
Subsequently,
SDSSD
(Ser,
Asp,
Ser,
Asp)
further
employed
engineer
bone‐targeting
nanovesicles
(BT‐NVs)
optimal
delivery
VDC
which
mitigates
loss
observed
severe
osteogenesis
imperfecta
Hence,
these
results
initially
uncover
promising
product,
VDC,
treatment
and
highlighting
its
translational
potential
clinical
applications.
Язык: Английский
Chemical Constituents of the Deep‐Sea‐Derived Penicillium citrinum W22 and Their Ferroptosis Inhibitory Activity
Zheng‐Biao Zou,
Yan‐Lin Ma,
Yan Li
и другие.
Chemistry & Biodiversity,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 17, 2025
ABSTRACT
One
new
monomeric
citrinin
analog
(
1
)
and
42
known
compounds
2–43
were
isolated
from
Penicillium
citrinum
W22.
The
structure
of
was
determined
by
detailed
analysis
the
1D
2D
nuclear
magnetic
resonance
(NMR),
HRESIMS,
time‐dependent
density
functional
theory
(TD‐DFT)‐based
electronic
circular
dichroism
(ECD)
calculation.
Penicitrinol
A
2
methyl
2‐(2‐acetyl‐3,5‐dihydroxy‐4,6‐dimethylphenyl)
acetate
11
significantly
inhibited
renin‐angiotensin
system‐selective
lethal
3
(RSL3)‐induced
ferroptosis
with
half
maximal
effective
concentration
(EC
50
values
1.6
34.0
µM,
respectively.
Язык: Английский
Exploring the bioactive potential of deep-sea microorganisms: A review of recent discoveries
Bioorganic Chemistry,
Год журнала:
2025,
Номер
161, С. 108521 - 108521
Опубликована: Апрель 26, 2025
Язык: Английский
In Vitro Insights into the Role of 7,8-Epoxy-11-Sinulariolide Acetate Isolated from Soft Coral Sinularia siaesensis in the Potential Attenuation of Inflammation and Osteoclastogenesis
Marine Drugs,
Год журнала:
2024,
Номер
22(2), С. 95 - 95
Опубликована: Фев. 19, 2024
The
balance
between
bone-resorbing
osteoclasts
and
bone-forming
osteoblasts
is
essential
for
the
process
of
bone
remodeling.
Excessive
osteoclast
differentiation
plays
a
pivotal
role
in
pathogenesis
diseases
such
as
rheumatoid
arthritis
osteoporosis.
In
present
study,
we
examined
whether
7,8-epoxy-11-sinulariolide
acetate
(Esa),
marine
natural
product
soft
coral
Sinularia
siaesensis,
attenuates
inflammation
osteoclastogenesis
vitro.
results
indicated
that
Esa
significantly
inhibited
lipopolysaccharide
(LPS)-induced
model
RAW264.7
cells
suppressed
receptor
activator
nuclear
factor-κB
ligand
(RANKL)-triggered
osteoclastogenesis.
down-regulated
protein
expression
iNOS,
COX-2,
TNF-α
by
inhibiting
NF-κB/MAPK/PI3K
pathways
reducing
release
reactive
oxygen
species
(ROS)
macrophages.
Besides,
treatment
osteoclast-specific
markers
NFATC1,
MMP-9,
CTSK
proteins.
These
findings
suggest
may
be
potential
agent
maintenance
homeostasis
associated
with
inflammation.
Язык: Английский
Chemical Constituents from the deep‐sea‐derived Fungus Aureobasidium melanogenum LUO5
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
21(6)
Опубликована: Апрель 12, 2024
Abstract
Three
new
C
10
and
12
aliphatic
δ
‐lactones
(
1
–
3
),
three
fatty
acid
methyl
esters
4
6
eight
known
compounds
7
14
)
were
isolated
from
the
marine
Aureobasidium
sp.
LUO5.
Their
structures
established
by
detailed
analyses
of
NMR,
HRESIMS,
optical
rotation,
ECD
data.
All
isolates
tested
for
their
inhibitory
effects
on
nitric
oxide
production
in
LPS‐induced
BV‐2
cells.
Notably,
compound
displayed
strongest
effect
with
IC
50
value
120.3
nM.
Язык: Английский
Theoretical and practical aspects of indirect spin–spin couplings
Royal Society of Chemistry eBooks,
Год журнала:
2024,
Номер
unknown, С. 24 - 52
Опубликована: Ноя. 15, 2024
The
review
gathers
the
most
important
works
on
SSCC,
considering
their
practical
and
theoretical
aspects.
These
chapters
deal
with
improvement
of
calculation
methods,
benchmark
calculations
using
large
sets
compounds,
measurements
coupling
constants
in
individual
application
to
exploration
conformations
as
well
couplings
through
unusual
chemical
bonds.
Finally,
examples
natural
compounds
were
provided
which
J(H,H)
J(C,H)
helpful
determining
structure.
This
covers
period
from
May
2023
April
2024.
Язык: Английский