Exploring the Antioxidant and Anti-Inflammatory Potential of Saffron (Crocus sativus) Tepals Extract within the Circular Bioeconomy
Antioxidants,
Год журнала:
2024,
Номер
13(9), С. 1082 - 1082
Опубликована: Сен. 4, 2024
Repurposing
saffron
(
Язык: Английский
Enhancing Industrial Hemp (Cannabis sativa) Leaf By-Products: Bioactive Compounds, Anti-Inflammatory Properties, and Potential Health Applications
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 548 - 548
Опубликована: Янв. 10, 2025
The
sustainable
utilization
of
biomass-derived
bioactives
addresses
the
growing
demand
for
natural
health
products
and
supports
development
goals
by
reducing
reliance
on
synthetic
chemicals
in
healthcare.
Cannabis
sativa
biomass,
particular,
has
emerged
as
a
valuable
resource
within
this
context.
This
study
focuses
hydroethanolic
extract
C.
leaves
(CSE),
which
exhibited
significant
levels
phenolic
compounds
contributing
to
robust
antioxidant
activity.
Evaluation
using
potassium
ferricyanide,
ABTS,
DPPH
methods
revealed
potent
radical
scavenging
activity
comparable
Trolox
standard.
UPLC-MS/MS
profiling
identified
cannabinoids
predominant
secondary
metabolites
CSE,
with
flavonoids
also
present
substantial
quantities.
investigated
anti-inflammatory
potential
CSE
RAW
264.7
macrophages
IL-1β-stimulated
C-20/A4
immortalized
human
chondrocytes,
demonstrating
protective
effects
without
cytotoxic
or
mutagenic
effects.
Mechanistically,
reduced
inflammation
inhibiting
MAPK
NF-κB
signaling
pathways.
In
silico
approaches
showed
ability
CSE's
main
bind
influence
activity,
confirming
vitro
evidence.
Incorporating
leaf
into
hyaluronic
acid-based
formulation
biotechnological
promise
treating
joint
inflammation.
Future
research
should
aim
elucidate
molecular
mechanisms
underlying
these
explore
CSE-derived
mitigating
osteoarthritis
progression.
approach
highlights
significance
utilizing
annually
increasing
biomass
waste
bioactivity
environmental
impact
reduction.
Язык: Английский
Review of Australian seaweed aquaculture: Limitations and opportunities with a focus on two candidate species; Asparagopsis taxiformis (Delile) Trevisan (1845) and Chaetomorpha linum (O.F. Müller) Kützing (1845)
Journal of Agriculture and Food Research,
Год журнала:
2025,
Номер
unknown, С. 101846 - 101846
Опубликована: Март 1, 2025
Язык: Английский
Senecio scandens Buch.-Ham. polysaccharides exert anti-atopic dermatitis effects by modulating gut microbiota and the MAPK/NF-κB pathway
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 26, 2025
This
study
aims
to
extract
polysaccharides
from
Senecio
scandens
Buch.-Ham.
(SSP)
using
alcohol
and
water
extraction
investigate
whether
they
can
be
delivered
orally
treat
atopic
dermatitis
(AD).
In
vivo
investigations
demonstrated
that
SSP
notably
improved
inflammation
in
mice,
reducing
ear
swelling,
scratching
frequency,
mast
cell
infiltration,
epidermal
thickness.
Furthermore,
it
lowered
the
levels
of
associated
inflammatory
markers,
increased
production
skin
barrier-associated
proteins,
restored
gut
microbial
diversity,
which
altered
composition
bacterial
communities.
vitro
experiments
could
diminish
factors
human
immortal
keratinocyte
line
(HaCaT)
suppress
MAPK/NF-κB
signaling
pathway.
Our
results
suggest
exerts
anti-AD
effects
regulates
gut–skin
axis
mice.
The
anti-inflammatory
mechanism
involves
It
is
being
tested
for
development
into
an
effective
drug
AD.
Язык: Английский
Infesting Seaweeds as a Novel Functional Food: Analysis of Nutrients, Antioxidants and ACE Inhibitory Effects
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(14), С. 7588 - 7588
Опубликована: Июль 10, 2024
Globalization
and
climate
change
are
both
contributing
to
an
increase
in
the
number
of
potentially
invasive
algae
coastal
areas.
In
terms
biodiversity
financial
losses,
invasiveness
has
become
a
significant
issue
Orbetello
Lagoon.
Indeed,
studies
from
Tuscany
Regional
Agency
for
Environmental
Protection
show
that
reduction
dissolved
oxygen
caused
by
algal
diffusion
is
detrimental
fisheries
biodiversity.
Considering
wakame
numerous
other
seaweeds
consumed
as
food
Asia,
we
assess
nutritional
nutraceutical
qualities
two
seaweeds:
Valonia
aegagrophila
Chaetomorpha
linum.
We
found
valuable
source
proteins
essential
amino
acids.
Even
if
fat
content
accounts
less
than
2%
dried
weight,
its
quality
high,
due
presence
unsaturated
fatty
Both
rich
antioxidants
pigments
polyphenols,
which
can
be
exploited
nutraceuticals.
Most
importantly,
human
gastrointestinal
digestion
increased
quantity
polyphenols
originated
secondary
metabolites
with
ACE
inhibitory
activity.
Taken
together,
our
data
strongly
promote
use
linum
functional
foods,
possible
application
treatment
hypertension
cardiovascular
diseases.
Язык: Английский
Repurposing Castanea sativa Spiny Burr By-Products Extract as a Potentially Effective Anti-Inflammatory Agent for Novel Future Biotechnological Applications
Life,
Год журнала:
2024,
Номер
14(6), С. 763 - 763
Опубликована: Июнь 15, 2024
The
concept
of
a
“circular
bioeconomy”
holds
great
promise
for
the
health,
cosmetic,
and
nutrition
sectors
by
re-using
Castanea
sativa
(Mill.)
by-products.
This
sustainable
resource
is
rich
in
bioactive
secondary
metabolites
with
antioxidant
anti-inflammatory
properties.
By
transforming
these
by-products
into
high-value
products
human
we
can
promote
economic
growth
reduce
environmental
impact
traditional
waste
disposal,
adding
value
to
previously
underutilized
resources.
In
present
study,
investigated
capacity,
phytochemical
composition,
vitro
activity
C.
burr
(CSB)
aqueous
extract.
spectrophotometric
study
revealed
high
total
phenolic
content
(TPC)
values
significant
anti-radical
Using
UPLC-MS/MS
techniques,
investigation
identified
56
metabolites,
confirming
presence
compounds
CSBs.
addition,
CSBs
significantly
downregulated
pro-inflammatory
mediators
LPS-stimulated
RAW
264.7
macrophage
cells
without
cell
toxicity.
Lastly,
silico
studies
pinpointed
three
kinases
from
as
binding
partners
ellagic
acid,
predominant
compound
found
our
These
findings
strongly
advocate
recycling
valorization
by-products,
challenging
their
conventional
classification
mere
“waste”.
Язык: Английский
The Beneficial Roles of Seaweed in Atopic Dermatitis
Marine Drugs,
Год журнала:
2024,
Номер
22(12), С. 566 - 566
Опубликована: Дек. 17, 2024
Atopic
dermatitis
(AD)
is
a
chronic,
inflammatory
skin
condition
characterized
by
severe
pruritus
and
recurrent
flare-ups,
significantly
impacting
patients’
quality
of
life.
Current
treatments,
such
as
corticosteroids
immunomodulators,
often
provide
symptomatic
relief
but
can
lead
to
adverse
effects
with
prolonged
use.
Seaweed,
sustainable
nutrient-dense
resource,
has
emerged
promising
alternative
due
its
rich
bioactive
compounds—polysaccharides,
phlorotannins,
polyphenols,
chlorophyll—that
offer
anti-inflammatory,
antioxidant,
immunomodulatory
properties.
This
review
explores
the
therapeutic
potential
brown,
red,
green
algae
in
alleviating
AD
symptoms,
highlighting
specific
species,
including
Undaria
pinnatifida,
Laminaria
japonica,
Chlorella
vulgaris,
Sargassum
horneri.
These
seaweeds
modulate
immune
responses,
reduce
epidermal
thickness,
restore
barrier
function,
presenting
novel,
safe,
effective
approach
management.
Further
clinical
studies
are
needed
confirm
their
efficacy
establish
dosing
strategies,
paving
way
for
seaweed-derived
therapies
natural
alternatives
treatment.
Язык: Английский