Recent Advances of the Zebrafish Model in the Discovery of Marine Bioactive Molecules DOI Creative Commons

Changyu Liu,

Jiaxun Li, Dexu Wang

и другие.

Marine Drugs, Год журнала: 2024, Номер 22(12), С. 540 - 540

Опубликована: Ноя. 30, 2024

Marine natural products are increasingly utilized in nutrition, cosmetics, and medicine, garnering significant attention from researchers globally. With the expansion of marine resource exploration recent years, demand for has risen, necessitating rapid cost-effective activity evaluations using model organisms. Zebrafish, a valuable vertebrate model, become an efficient tool screening identifying safe, active molecules products. This review, based on nearly 10 years literature, summarizes current status progress zebrafish models evaluating product bioactivity. It also highlights their potential exploring resources with health benefits, offering reference future development utilization biological resources.

Язык: Английский

Methyl 3-Bromo-4,5-dihydroxybenzoate Attenuates Inflammatory Bowel Disease by Regulating TLR/NF-κB Pathways DOI Creative Commons
Jing Huang, Lei Li,

Liyan Xu

и другие.

Marine Drugs, Год журнала: 2025, Номер 23(1), С. 47 - 47

Опубликована: Янв. 19, 2025

Inflammatory bowel disease (IBD) is characterized by uncontrolled, chronic relapsing inflammation in the gastrointestinal tract and has become a global healthcare problem. Here, we aimed to illustrate anti-inflammatory activity underlying mechanism of methyl 3-bromo-4,5-dihydroxybenzoate (MBD), compound derived from marine organisms, especially IBD, using zebrafish model. The results indicated that MBD could inhibit inflammatory responses induced CuSO4, tail amputation LPS zebrafish. Furthermore, notably inhibited intestinal migration immune cells, enhanced integrity gut mucosal barrier improved peristalsis function IBD model trinitro-benzene-sulfonic acid (TNBS). In addition, ROS elevation TNBS. Network pharmacology analysis, molecular docking, transcriptomics sequencing RT-PCR were conducted investigate potential mechanism. showed regulate TLR/NF-κB pathways inhibiting mRNA expression TNF-α, NF-κB, IL-1, IL-1β, IL6, AP1, IFNγ, IKKβ, MyD88, STAT3, TRAF1, TRAF6, NLRP3, NOD2, TLR3 TLR4, promoting IL4, IκBα Bcl-2. conclusion, these findings indicate be candidate for treatment IBD.

Язык: Английский

Процитировано

0
IHNV induced miR-19-3p modulates intestinal immune response of rainbow trout (Oncorhynchus mykiss) by targeting DHX58-dependent RLR signaling pathway in vitro and in vivo DOI
Lu Zhao, Jinqiang Huang, Xin Fu

и другие.

Fish & Shellfish Immunology, Год журнала: 2025, Номер unknown, С. 110200 - 110200

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
A novel synthetic oxazolidinone derivative BS-153 attenuated LPS-induced inflammation via inhibiting NF-κB/pkcθ signaling pathway DOI

Liyan Xu,

Jing Huang, Rongchun Wang

и другие.

Fish & Shellfish Immunology, Год журнала: 2025, Номер unknown, С. 110292 - 110292

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Recent Advances of the Zebrafish Model in the Discovery of Marine Bioactive Molecules DOI Creative Commons

Changyu Liu,

Jiaxun Li, Dexu Wang

и другие.

Marine Drugs, Год журнала: 2024, Номер 22(12), С. 540 - 540

Опубликована: Ноя. 30, 2024

Marine natural products are increasingly utilized in nutrition, cosmetics, and medicine, garnering significant attention from researchers globally. With the expansion of marine resource exploration recent years, demand for has risen, necessitating rapid cost-effective activity evaluations using model organisms. Zebrafish, a valuable vertebrate model, become an efficient tool screening identifying safe, active molecules products. This review, based on nearly 10 years literature, summarizes current status progress zebrafish models evaluating product bioactivity. It also highlights their potential exploring resources with health benefits, offering reference future development utilization biological resources.

Язык: Английский

Процитировано

0