Journal of Sol-Gel Science and Technology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 3, 2025
Язык: Английский
BioNanoScience, Год журнала: 2025, Номер 15(1)
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
Antioxidants, Год журнала: 2025, Номер 14(1), С. 88 - 88
Опубликована: Янв. 13, 2025
The rising global focus on healthy lifestyles and environmental sustainability has prompted interest in repurposing plant-based by-products for health benefits. With increasing life expectancy, the incidence of neurodegenerative diseases—characterized by complex, multifactorial mechanisms such as abnormal protein aggregation, mitochondrial dysfunction, oxidative stress, inflammation—continues to grow. Medicinal plants, with their diverse bioactive compounds, offer promising therapeutic avenues conditions. Myrtus communis L., a Mediterranean plant primarily used liquor production, generates significant waste rich antioxidant anti-inflammatory properties. This study explores neuroprotective potential berry cellular model neurodegeneration. Using PC12 cells exposed 6-hydroxydopamine (6-OHDA), we assessed cell viability via MTT assay measured reactive oxygen species (ROS) production using DCFDA fluorescence. Additionally, analyzed expression genes linked stress neuronal function, including AChE, PON2, Grin1, Gabrd, c-fos, RT-PCR. Our findings reveal that extract significantly protects against 6-OHDA-induced cytotoxicity, reduces ROS levels, modulates key stress-related genes, underscoring its agent. These results highlight promise extracts mitigating processes, paving way future interventions.
Язык: Английский
Процитировано
0
Materials, Год журнала: 2025, Номер 18(2), С. 382 - 382
Опубликована: Янв. 15, 2025
Infections continue to pose significant challenges in dentistry, necessitating the development of innovative solutions that can effectively address these issues. This study focuses on creating coatings made from polymethyl methacrylate (PMMA) enriched with zinc oxide-silver composite nanoparticles, layered Ti6Al4V-titanium alloy substrates. The application materials aims create a solution for abutments utilized complete dental implant systems, representing area most susceptible bacterial infections. nanoparticles were synthesized using hydrothermal method, optimized through specific temperature and pressure parameters achieve effective morphologies sizes enhance antibacterial efficacy. layers applied titanium substrate spin coating technique, chosen its advantages compatibility involved. Comprehensive analyses conducted antimicrobial powders, including X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, energy-dispersive spectroscopy. Furthermore, PMMA-based incorporating evaluated ensure uniformity homogeneity across surface by IR mapping SBF immersion-SEM analysis. activity samples was demonstrated impressive results against Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, as assessed biofilm modulation studies. biocompatibility validated vitro cell-based assays, which excellent between human preosteoblasts, confirming their potential suitability future use implants.
Язык: Английский
Процитировано
0
Molecules, Год журнала: 2025, Номер 30(3), С. 487 - 487
Опубликована: Янв. 22, 2025
Photodynamic therapy (PDT) holds considerable promise for advancing anticancer treatment, owing to its precision and minimally invasive nature. In this study, we successfully synthesized a series of titanium carbide (Ti3C2, TC)/graphitic carbon nitride (g-C3N4, CN) nanocomposite through synergistic approach combining electron beam irradiation 2D/2D composite formation. According the results, 1TC/200-CN (1TC, which TC was 1, referred mass ratio; 200-CN, CN 200 kGy, metering) displayed 94% degradation rate methylene blue (10 mg/L) in 100 min. Furthermore, proliferation CAL-27 cells suppressed just 23.3% at concentration 320 μg/mL 1TC/200-CN. Notably, group treated with exhibited largest residual scratch area, accompanied by notable decrease mitochondrial membrane potential. These enhanced effects were attributed efficient transfer electron-hole pairs facilitated TC/CN composite. Our findings not only contribute development stable nanocomposites PDT applications but also provide valuable insights into utilization nanomaterials biomedical field, thereby paving way potential breakthroughs cancer treatment.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2518 - 2518
Опубликована: Март 11, 2025
This study investigates silver (Ag), copper oxide (CuO), and bimetallic Ag/CuO nanoparticles (NPs) synthesized using Cistus creticus L. extract, focusing on their synthesis, physicochemical characteristics, antioxidant activity. Green synthesis methods utilizing plant extracts offer environmentally benign routes for nanoparticle fabrication, attracting significant interest across multiple fields. NP formation was confirmed by UV/Vis total X-ray fluorescence (TXRF) spectroscopy, while dynamic electrophoretic light scattering (DLS, ELS) characterized particle size ζ-potential, respectively. AgNPs exhibited the smallest (30.8 ± 8.81 nm), CuONPs had largest (44.07 19.19 nm). For Ag/CuONPs, ζ-potential value −77.9 2.99 mV. Morphological structural analyses performed transmission electron microscopy (TEM), selected area diffraction (SAED), (XRD) revealed that were spherical, Ag/CuONPs spherical polymorphic structures. Colloidal stability studies over 60 days demonstrated NPs highly stable, indicating suitability pharmaceutical cosmetic applications. Antioxidant activity, assessed via DPPH assay, highest free radical scavenging By systemically comparing Ag, CuO, from this provides valuable insights development of tailored nanomaterials with diverse applications in pharmaceutics cosmetics.
Язык: Английский
Процитировано
0
Journal of Sol-Gel Science and Technology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 3, 2025
Язык: Английский
Процитировано
0