Development and Validation of a Screening Equation for Obstructive Sleep Apnea

Diagnostics, Год журнала: 2025, Номер 15(4), С. 427 - 427

Опубликована: Фев. 10, 2025

Background: The high prevalence of obstructive sleep apnea (OSA), about 30% people worldwide over 30 years old, underscores the crucial need for early screening. This study aimed to identify key predictive factors OSA; use these develop a screening equation population at risk and prospectively validate this equation's application. Methods: included two phases: retrospective phase examining anthropometric data, Epworth sleepiness scale (ESS), home test (HSAT) from 200 patients referred Respiratory Sleep Disorder Center Policlinico Umberto I, Rome, Italy (January 2020-January 2023) create OSA using multivariate analysis (with most data according scientific literature). A prospective testing on 53 May 2023 September 2024. Results: In phase, variables apnea-hypopnea index (AHI) identified were neck circumference (NC) (ESS). derived was as follows: AHIp = [-70.498 + (2.196 × NC) (0.809 ESS)]. study, we compared AHI predicted by (AHIp) with measured via HSAT (AHIm) in recruited. results showed that had sensitivity 95%, specificity 28%, positive value (PPV) 46%, negative (NPV) 90%. Conclusions: NC ESS predictors OSA, forming equation. equation, showing NPV, may be useful method rule out OSA.

Язык: Английский

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Weight Reduction with GLP-1 Agonists and Paths for Discontinuation While Maintaining Weight Loss

Biomolecules, Год журнала: 2025, Номер 15(3), С. 408 - 408

Опубликована: Март 13, 2025

Worldwide, nearly 40% of adults are overweight and 13% obese. Health consequences excess weight include cardiovascular diseases, type 2 diabetes, dyslipidemia, increased mortality. Treating obesity is challenging calorie restriction often leads to rebound gain. Treatments such as bariatric surgery create hesitancy among patients due their invasiveness. GLP-1 medications have revolutionized loss can reduce body in obese by between 15% 25% on average after about 1 year. Their mode action mimic the endogenous GLP-1, an intestinal hormone that regulates glucose metabolism satiety. However, drugs carry known risks and, since use for recent, may unforeseen well. They a boxed warning people with personal or family history medullary thyroid carcinoma multiple endocrine neoplasia syndrome 2. Gastrointestinal adverse events (nausea, vomiting, diarrhea) fairly common while pancreatitis obstruction rarer. There be lean mass well premature facial aging. A significant disadvantage using these high rate regain when they discontinued. Achieving success pharmacologic treatment then weaning avoid future negative effects would ideal.

Язык: Английский

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EFFECTIVENESS OF BARIATRIC SURGERY IN PATIENTS WITH SEVERE OBESITY OBSTRUCTIVE SLEEP APNEA

Journal of Gastrointestinal Surgery, Год журнала: 2025, Номер unknown, С. 101957 - 101957

Опубликована: Янв. 1, 2025

Язык: Английский

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The Effects of Intraperitoneal Dexmedetomidine in Comparison with Ropivacaine in Postoperative Pain After Laparoscopic Sleeve Gastrectomy: A Double-Blind, Randomized, Placebo-Controlled, Clinical Trial

Obesity Surgery, Год журнала: 2025, Номер unknown

Опубликована: Апрель 26, 2025

Язык: Английский

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Association between body roundness index and obstructive sleep apnea: a cross-sectional study from the NHANES (2005–2008 to 2015–2020)

BMC Oral Health, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 30, 2025

Obstructive sleep apnea (OSA) is linked to obesity, and the body roundness index (BRI) an innovative measure of obesity that more accurately reflects visceral total fat. The relationship between BRI likelihood OSA unclear, so we aimed investigate association prevalence OSA. We used data from National Health Nutrition Examination Survey (NHANES; 2005-2008 2015-2020) conduct a cross-sectional study involving 24,476 individuals aged 18 years or older. was assessed using three standardized NHANES questionnaire items measuring monthly daytime sleepiness, weekly events, habitual snoring frequency. A formula uses height waist measures measurements calculate BRI. Covariates, including sex, age, race/ethnicity, education level, marital status, poverty-income ratio (PIR), alcohol consumption, smoking high blood pressure (HBP), diabetes, duration were controlled multivariate logistic regression models. Subgroup analyses, interaction tests, smoothed curve fitting also performed. After controlling for confounders, showed positive correlation with Among participants older, 11,856 diagnosed full model revealed significant incidence (OR = 1.11, 95% CI: 1.08-1.14, p < 0.0001). Participants in highest percentile had 87% greater developing compared those lowest 1.87, 1.62-2.16, levels have shown favorable rising rates United States. serves as straightforward anthropometric predictor

Язык: Английский

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Association between body roundness index and obstructive sleep apnea among US adults: data from the 2005–2008 and 2015–2018 National Health and Nutrition Examination Survey

Sleep and Biological Rhythms, Год журнала: 2025, Номер 23(2), С. 171 - 179

Опубликована: Янв. 17, 2025

Язык: Английский

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The Interplay between Asthma, Obesity, and Obstructive Sleep Apnea

Seminars in Respiratory and Critical Care Medicine, Год журнала: 2025, Номер unknown

Опубликована: Март 31, 2025

Abstract The interrelationship between asthma, obesity, and obstructive sleep apnea (OSA) presents a critical area of investigation within medicine, given the rising prevalence these conditions globally. This article explores multifactorial interactions among three disorders that contribute to significant morbidity. Asthma, chronic inflammatory condition airways, is one most common respiratory Asthma in people with obesity associated poor asthma control, increased severity, an frequency exacerbations. Obesity, characterized by excessive fat accumulation, well-established risk factor for development OSA. sleep-related breathing disorder disrupts airflow during due pharyngeal collapse. Conversely, OSA may worsen symptoms through intermittent hypoxia fragmentation, further complicating management. review analyzes existing literature illustrate bidirectional relationships conditions. It discusses role systemic inflammation, hormone dysregulation, lifestyle factors, such as diet physical inactivity, persistence obese patients. Furthermore, it highlights importance comprehensive management strategies address overlapping disorders. Clinical implications are examined, consideration potential targeted therapies interventions could mitigate improve quality life affected individuals. Understanding complex essential healthcare practitioners optimizing patients By recognizing interconnectedness conditions, clinicians can adopt more holistic approach treatment, leading improved outcomes better understanding patient's overall health trajectory. Future research directions suggested investigate therapeutic influence socioeconomic factors on

Язык: Английский

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Staging of obesity-associated hypoventilation in patients with morbid obesity scheduled for bariatric surgery

Chronic Respiratory Disease, Год журнала: 2025, Номер 22

Опубликована: Апрель 1, 2025

Background: Almost 20% of Polish citizens aged >15 years are obese and this number is increasing. Numerous obesity-associated diseases include, quite notably, also sleep-related breathing disorders hypoventilation. This study aimed to analyse the prevalence obesity hypoventilation syndrome (OHS) staging in a group patients qualified for bariatric surgery within Comprehensive Specialist Care Bariatrics (KOS-BAR) pilot program designed running Poland since 2021. Methods: Prior procedure, participants were referred pulmonologist assessment. We retrospectively analysed records 134 patients. Results: all tested ( n = 122, 91.0%) had obstructive sleep apnea mainly classified as severe (59.0%). Hypoventilation was confirmed 30 (22.4%), 37.9% them, increased levels serum bicarbonate found. Chronic diurnal hypercapnia 7.9% (10/122). Conclusions: well population significant issue. The presented included stages 0–IV conducted analysis suggests that most common form among (stage I).

Язык: Английский

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Analysis of the clinical-organizational pathway and well-being of obese patients undergoing bariatric surgery: impact on satisfaction and quality of life

Psychology Health & Medicine, Год журнала: 2025, Номер unknown, С. 1 - 17

Опубликована: Май 9, 2025

Bariatric surgery is an effective treatment for obesity, promoting significant and lasting weight loss while improving health quality of life. The study examines the clinical organizational pathway patients undergoing it, assessing impact services on their well-being through status analysis. It also seeks to understand whether patient satisfaction during care process correlates with improved A total 50 severe obesity were included between July 2020 October 2022. evaluation was conducted using Short Form Health Survey 36 ad hoc questionnaire at three stages: before intervention (T0), six months (T1) 12 (T2). ANOVA analysis showed differences T0, T1 T2 most variables except number professionals consulted (p = 0.09). Tukey post-hoc test confirmed these several variables, some exceptions, including medication use (T0-T1: p 0.14), 0.68; T0-T2: 0.08; T1-T2: 0.37), patient-care team relationship 0.08). confirms effectiveness bariatric emphasizes importance a multidisciplinary approach management.

Язык: Английский

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Management of sleep-disordered breathing in achondroplasia: guiding principles of the European Achondroplasia Forum

Orphanet Journal of Rare Diseases, Год журнала: 2025, Номер 20(1)

Опубликована: Май 15, 2025

Язык: Английский

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