Association between serum retinol-binding protein and lower limb atherosclerosis risk in type 2 diabetes mellitus
World Journal of Diabetes,
Год журнала:
2025,
Номер
16(3)
Опубликована: Янв. 20, 2025
BACKGROUND
Serum
retinol-binding
protein
(RBP)
is
the
primary
transport
of
circulating
vitamin
A.
RBP
has
a
crucial
role
in
maintaining
nutrient
metabolism
and
physiologic
homeostasis.
Several
studies
have
indicated
that
serum
participates
progression
diabetes
diabetes-related
complications.
However,
impact
on
lower
limb
atherosclerosis
not
been
determined
individuals
with
type
2
mellitus
(T2DM).
AIM
To
determine
association
between
T2DM.
METHODS
This
retrospective
study
enrolled
4428
eligible
T2DM
patients
divided
into
non-lower
(n
=
1913)
groups
2515)
based
arterial
ultrasonography
results.
At
hospital
admission,
baseline
levels
were
assessed,
all
subjects
categorized
three
(Q1-Q3)
tertiles.
Logistic
regression,
restricted
cubic
spline
subgroup
analysis,
machine
learning
used
to
assess
risk.
RESULTS
Among
T2DM,
2515
(56.80%)
had
atherosclerosis.
analysis
showed
risk
increased
by
1%
for
every
1
unit
rise
level
(odds
ratio
1.01,
95%
confidence
interval:
1.00-1.02,
P
0.004).
Patients
highest
tertile
group
(Q3)
higher
compared
lowest
(Q1)
1.36,
1.12-1.67,
0.002).
The
gradually
an
increase
(P
trend
0.005).
Restricted
linear
correlation
(non-linear
<
0.05).
Machine
demonstrated
significance
diagnostic
value
predicting
CONCLUSION
Elevated
correlate
Язык: Английский
NIR-II imaging-based detection of early changes in lower limb perfusion in type 2 diabetes patients without peripheral artery disease
Yijie Ning,
Jie Hu,
Yikun Zhu
и другие.
Diabetes Research and Clinical Practice,
Год журнала:
2025,
Номер
unknown, С. 112038 - 112038
Опубликована: Фев. 1, 2025
Highlights•NIR-II
imaging
is
a
new
and
noninvasive
technique
to
visualize
lower
limb
perfusion.•NIR-II
can
detect
early
changes
in
perfusion
T2D
patients.•NIR-II
the
dorsal
microvessel
venous
real
time.•Among
clinical
characteristics,
age
sex
were
independent
predictors
of
arterial
plaques.•Based
on
NIR-II
imaging,
prevention
be
carried
out
individuals
at
high
risk
for
PAD.Graphical
abstractAbstractAimsThe
formation
plaques,
exacerbated
by
type
2
diabetes
(T2D),
represents
an
stage
peripheral
artery
disease
(PAD).
Second
near-infrared
region
(NIR-II)
emerging
with
sensitivity
detecting
levels.
This
study
explores
value
identifying
due
extremity
plaques
patients
without
PAD.MethodsNIR-II
indocyanine
green
(ICG)
was
conducted
120
patients,
who
categorized
into
two
groups:
plaque
non-plaque.
parameters
characteristics
analyzed
between
groups
identify
significant
plaques.ResultsSix
(T
start,
T
1/2,
Tmax,
Ingress
rate,
Egress,
Egress
rate)
showed
differences
diagnostic
efficacy
groups.
Three
(age
sex)
identified
as
plaques.
The
nomogram
that
combined
model
exhibited
higher
efficacy.ConclusionNIR-II
effectively
showing
great
potential
pre-diagnosis
PAD.
Язык: Английский
Assessment of the diabetic foot in inpatients
British Journal of Nursing,
Год журнала:
2025,
Номер
34(4), С. S12 - S23
Опубликована: Фев. 19, 2025
Diabetic
foot
disease
is
a
severe
complication
of
diabetes,
leading
to
significant
morbidity
and
lower
limb
amputations.
This
review
explores
the
pathophysiology
diabetic
disease,
highlighting
roles
peripheral
neuropathy,
arterial
immunosuppression
in
development
ulcers
infections.
Key
intrinsic
extrinsic
risk
factors,
including
long-standing
poor
glycaemic
control,
inappropriate
footwear
trauma
are
discussed.
The
importance
comprehensive
assessments
using
diagnostic
tools
such
as
Ipswich
Touch
Test
Doppler
studies
emphasised
for
early
detection
management.
Challenges
delays
referral
specialist
care,
limited
access
multidisciplinary
teams,
staffing
shortages
identified
critical
barriers
effective
care.
builds
upon
extant
literature
by
integrating
most
recent
evidence,
2023
guidelines
from
International
Working
Group
on
Foot.
It
emphasises
practical
application,
detailed
pathways
care
strategies,
offering
updated
insights
improve
clinical
outcomes
address
often
overlooked
aspects
within
inpatient
services.
Future
directions
encompass
advances
imaging,
telemedicine
patient
education,
which
may
further
optimise
preventive
therapeutic
strategies
disease.
Язык: Английский
Neutrophil-to-lymphocyte ratio in type 2 diabetes patients combined with Lower Extremity Peripheral Artery Disease
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 30, 2024
This
study
explored
the
utility
of
NLR
(neutrophil-to-lymphocyte
ratio)
as
a
marker
to
predict
Lower
Extremity
Peripheral
Artery
Disease
(PAD)
in
Chinese
population,
well
assess
its
consistency
and
diagnostic
value
with
digital
subtraction
angiography.
Язык: Английский
Evaluation of wound temperature monitoring at various anatomical sites in the management of patients with diabetic foot undergoing microcirculation reconstruction
Journal of Orthopaedic Surgery and Research,
Год журнала:
2024,
Номер
19(1)
Опубликована: Ноя. 20, 2024
This
study
aims
to
assess
the
significance
of
monitoring
temperature
change
trends
at
various
wound
sites
in
healing
process
diabetic
foot
ulcers
after
microcirculation
reconstruction
surgery.
A
retrospective
analysis
was
conducted
on
individuals
with
who
had
been
admitted
Department
Orthopedics
Second
Hospital
Shanxi
Medical
University
between
July
2020
and
February
2022.
Temperature
changes
were
regularly
monitored
center
distal
tibia
ipsilateral
lower
leg
microcirculatory
blood
perfusion.
Wound,
ischemia,
infection
(WIFi)
grading
performed
admission
final
follow-up
determine
value
sites.
Additionally,
formation
collateral
microarterial
vessels
their
consistency
observed
differences.
Follow-up
assessments
included
recurrence
ulcers,
development
different
locations,
re-amputation
toe
or
limb,
diabetes-related
mortality.
total
29
patients
follow-up,
an
average
age
57.14
±
14.75
years
a
period
9.79
4.13
months.
Following
surgery,
as
microvascular
network
formed,
difference
same
side
gradually
decreased,
no
statistical
4
weeks
postoperatively.
At
both
there
significant
reduction
(W)
ischemia
(I)
grades
within
WIFi
classification.
The
showed
progressive
improvement
developed.
During
period,
2
cases
ulcer
recurrence,
1
case
appearing
location,
fatalities.
Skin
offers
direct
reliable
indication
Its
simplicity
cost-effectiveness
make
it
valuable
tool
for
widespread
use
evaluating
following
Язык: Английский